公开(公告)号：US11548894B2

公开(公告)日：2023-01-10

申请号：US16139865

申请日：2018-09-24

Applicant: The Board of Regents of the University of Texas System

Inventor： Jef DeBrabander ,  Luis Parada

IPC: C07D487/04 ,  C07C205/58 ,  C07D207/09 ,  C07D209/48 ,  C07D211/14 ,  C07D213/16 ,  C07D213/70 ,  C07C205/61 ,  C07C235/50 ,  C07C255/57 ,  C07C271/20 ,  C07C323/22 ,  C07D401/12 ,  C07D307/14 ,  C07D295/13 ,  C07C323/62

Abstract: The described invention provides small molecule anti-cancer compounds for treating tumors that respond to cholesterol biosynthesis inhibition. The compounds selectively inhibit the cholesterol biosynthetic pathway in tumor-derived cancer cells, but do not affect normally dividing cells.

公开(公告)号：US20170114062A1

公开(公告)日：2017-04-27

申请号：US15194825

申请日：2016-06-28

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jef DeBrabander ,  Luis Parada

IPC: C07D487/04 ,  C07D213/16 ,  C07D207/09 ,  C07C323/22 ,  C07D295/13 ,  C07D401/12 ,  C07C205/58 ,  C07D213/70 ,  C07C255/57 ,  C07D307/14 ,  C07D209/48 ,  C07C235/50 ,  C07C205/61 ,  C07D211/14 ,  C07C271/20 ,  C07C323/62

CPC classification number: C07D487/04 ,  C07C205/58 ,  C07C205/61 ,  C07C235/50 ,  C07C255/57 ,  C07C271/20 ,  C07C323/22 ,  C07C323/62 ,  C07D207/09 ,  C07D209/48 ,  C07D211/14 ,  C07D213/16 ,  C07D213/70 ,  C07D295/13 ,  C07D307/14 ,  C07D401/12

Abstract: The described invention provides small molecule anti-cancer compounds for treating tumors that respond to cholesterol biosynthesis inhibition. The compounds selectively inhibit the cholesterol biosynthetic pathway in tumor-derived cancer cells, but do not affect normally dividing cells.

公开(公告)号：US10112948B2

公开(公告)日：2018-10-30

申请号：US15194825

申请日：2016-06-28

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jef DeBrabander ,  Luis Parada

IPC: C07D487/04 ,  C07D213/16 ,  C07D207/09 ,  C07C323/22 ,  C07D295/13 ,  C07D401/12 ,  C07C205/58 ,  C07D213/70 ,  C07C255/57 ,  C07D307/14 ,  C07D209/48 ,  C07C235/50 ,  C07C205/61 ,  C07D211/14 ,  C07C271/20 ,  C07C323/62

Abstract: The described invention provides small molecule anti-cancer compounds for treating tumors that respond to cholesterol biosynthesis inhibition. The compounds selectively inhibit the cholesterol biosynthetic pathway in tumor-derived cancer cells, but do not affect normally dividing cells.