公开(公告)号：US20250092468A1

公开(公告)日：2025-03-20

申请号：US18965965

申请日：2024-12-02

Applicant: The Board of Regents of The University of Texas System

Inventor： Min Soo KIM ,  James BRUGAROLAS ,  Tae Hyun HWANG ,  Yang XIE

IPC: C12Q1/6886 ,  A61P35/00 ,  C12N15/52 ,  C40B40/08 ,  G01N33/50 ,  G16B25/00 ,  G16B25/10 ,  G16B25/20 ,  G16B30/00 ,  G16H50/20 ,  G16H50/30

Abstract: Described herein are methods and systems for identifying and/or treating subjects having cancer who are more likely to respond to treatment with an inhibitor of the transcription factor HIF-2α.

公开(公告)号：US20240035091A1

公开(公告)日：2024-02-01

申请号：US18265571

申请日：2021-12-08

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Yang XIE ,  Guanghua XIAO

IPC: C12Q1/6886 ,  G16B25/10 ,  G16H20/10 ,  G16H50/30

CPC classification number: C12Q1/6886 ,  G16B25/10 ,  G16H20/10 ,  G16H50/30 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/106

Abstract: Provided herein is a 7-genes signature, an algorithm to evaluate a patient's risk score, and methods of use thereof. The methods provided herein include methods of use of a risk score to predict lung cancer patient survival and lung cancer patient likelihood to respond to adjuvant chemotherapy.

公开(公告)号：US20210222257A1

公开(公告)日：2021-07-22

申请号：US17206895

申请日：2021-03-19

Applicant: The Board of Regents of the University of Texas System

Inventor： Min Soo KIM ,  James BRUGAROLAS ,  Tae Hyun HWANG ,  Yang XIE

IPC: C12Q1/6886 ,  C12N15/52 ,  C40B40/08 ,  G01N33/50 ,  G16B25/00 ,  G16H50/30 ,  G16H50/20 ,  A61P35/00 ,  G16B30/00

Abstract: Described herein are methods and systems for identifying and/or treating subjects having cancer who are more likely to respond to treatment with an inhibitor of the transcription factor HIF-2α.

公开(公告)号：US20190048421A1

公开(公告)日：2019-02-14

申请号：US15761534

申请日：2016-09-16

Applicant: The Board of Regents of the University of Texas System

Inventor： Min Soo KIM ,  James BRUGAROLAS ,  Tae Hyun HWANG ,  Yang XIE

IPC: C12Q1/6886 ,  G16H50/20 ,  G06F19/22 ,  C12N15/52 ,  G16H50/30 ,  A61P35/00

Abstract: Described herein are methods and systems for identifying and/or treating subjects having cancer who are more likely to respond to treatment with an inhibitor of the transcription factor HIF-2α.

公开(公告)号：US20210263045A1

公开(公告)日：2021-08-26

申请号：US17045482

申请日：2019-04-08

Applicant: The Board of Regents of the University of Texas System

Inventor： Edward WAKELAND ,  David E. GERBER ,  Quan LI ,  Shaheen KHAN ,  Saad KHAN ,  Yang XIE ,  Jason Y. Park ,  Farjana FATTAH ,  Xin LUO

IPC: G01N33/68 ,  G01N33/564 ,  C07K16/28

Abstract: The present disclosure is directed to methods and compositions for the prediction and treatment of immunotherapy—induced toxicities, as well as improved methods for the treatment of cancer with immunotherapies.

公开(公告)号：US20200284803A1

公开(公告)日：2020-09-10

申请号：US16487335

申请日：2018-02-19

Applicant: The Board of Regents of the University of Texas System

Inventor： David E. GERBER ,  Edward WAKELAND ,  Quan LI ,  Saad KHAN ,  Jason Y. PARK ,  Xin LUO ,  Yang XIE

IPC: G01N33/68 ,  C07K16/28

Abstract: The present disclosure is directed to methods and compositions for the prediction and treatment of immunotherapy-induced toxicities, as well as improved methods for the treatment of cancer with immunotherapies.