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    Direct Conversion of Cells to Cells of Other Lineages
    4.
    发明申请
    Direct Conversion of Cells to Cells of Other Lineages 有权
    将细胞直接转化为其他谱系的细胞

    公开(公告)号：US20150284681A1

    公开(公告)日：2015-10-08

    申请号：US14711514

    申请日：2015-05-13

    申请人： The Board of Trustees of the Leland Stanford Junior University

    发明人： Marius Wernig ,  Thomas C. Sudhof ,  Thomas Vierbuchen ,  Austin Ostermeier ,  Zhiping Pang

    IPC分类号： C12N5/0793 ,  G01N33/50 ,  C12N5/079

    CPC分类号： C12N5/0619 ,  C12N5/0622 ,  C12N5/0623 ,  C12N2501/60 ,  C12N2506/02 ,  C12N2506/1307 ,  C12N2506/14 ,  C12N2506/45 ,  C12N2510/00 ,  G01N33/5058

    摘要： Methods, compositions and kits for producing functional neurons, astroctyes, oligodendrocytes and progenitor cells thereof are provided. These methods, compositions and kits find use in producing neurons, astrocytes, oligodendrocytes, and progenitor cells thereof for transplantation, for experimental evaluation, as a source of lineage- and cell-specific products, and the like, for example for use in treating human disorders of the CNS. Also provided are methods, compositions and kits for screening candidate agents for activity in converting cells into neuronal cells, astrocytes, oligodendrocytes, and progenitor cells thereof.

    摘要翻译： 提供了用于产生功能性神经元，星形星，少突胶质细胞和祖细胞的方法，组合物和试剂盒。 这些方法，组合物和试剂盒可用于产生用于移植的神经元，星形胶质细胞，少突胶质细胞和祖细胞，用于实验评价，作为谱系和细胞特异性产物的来源等，例如用于治疗人 中枢神经系统疾病 还提供了用于筛选候选试剂以将细胞转化成神经元细胞，星形胶质细胞，少突胶质细胞和祖细胞的活性的方法，组合物和试剂盒。