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公开(公告)号：US20190249147A1
公开(公告)日：2019-08-15
申请号：US16310632
申请日：2017-06-20
CPC分类号： C12N5/0697 , C12N2501/11 , C12N2501/155 , C12N2501/33 , C12N2501/60 , C12N2502/081 , C12N2502/086 , C12N2503/04 , C12N2533/90 , G01N33/5058 , G01N33/54373
摘要： Compositions and methods are provided for biologically relevant in vitro screening of neural function, including determination of the effects of an agent on neural cells. The compositions of the invention useful in such screening methods include a neural co-culture system comprising human pluripotent stem cell (PSC)-derived neurons and human glial cells, which may be derived by culture methods allowing for rapid and robust development of highly mature neuronal activity, particularly spontaneous synchronous network bursts.
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公开(公告)号：US20170369840A1
公开(公告)日：2017-12-28
申请号：US15651910
申请日：2017-07-17
IPC分类号： C12N5/0793 , C12N5/079 , G01N33/50 , C12N5/0797
CPC分类号： C12N5/0619 , C12N5/0622 , C12N5/0623 , C12N2501/60 , C12N2506/02 , C12N2506/1307 , C12N2506/14 , C12N2506/45 , C12N2510/00 , G01N33/5058
摘要： Methods, compositions and kits for producing functional neurons, astroctyes, oligodendrocytes and progenitor cells thereof are provided. These methods, compositions and kits find use in producing neurons, astrocytes, oligodendrocytes, and progenitor cells thereof for transplantation, for experimental evaluation, as a source of lineage- and cell-specific products, and the like, for example for use in treating human disorders of the CNS. Also provided are methods, compositions and kits for screening candidate agents for activity in converting cells into neuronal cells, astrocytes, oligodendrocytes, and progenitor cells thereof.
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公开(公告)号：US20230045590A1
公开(公告)日：2023-02-09
申请号：US17786359
申请日：2020-12-21
发明人： Anthony E. Oro , Marius Wernig
摘要： Compositions and methods are provided for production of cells useful in regenerative therapies.
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公开(公告)号：US20180057789A1
公开(公告)日：2018-03-01
申请号：US15723926
申请日：2017-10-03
IPC分类号： C12N5/0793 , C12N5/079 , C12N5/0797 , G01N33/50
CPC分类号： C12N5/0619 , C12N5/0622 , C12N5/0623 , C12N2501/60 , C12N2506/02 , C12N2506/1307 , C12N2506/14 , C12N2506/45 , C12N2510/00 , G01N33/5058
摘要： Methods, compositions and kits for producing functional neurons, astroctyes, oligodendrocytes and progenitor cells thereof are provided. These methods, compositions and kits find use in producing neurons, astrocytes, oligodendrocytes, and progenitor cells thereof for transplantation, for experimental evaluation, as a source of lineage- and cell-specific products, and the like, for example for use in treating human disorders of the CNS. Also provided are methods, compositions and kits for screening candidate agents for activity in converting cells into neuronal cells, astrocytes, oligodendrocytes, and progenitor cells thereof.
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公开(公告)号：US20220348885A1
公开(公告)日：2022-11-03
申请号：US17863152
申请日：2022-07-12
IPC分类号： C12N5/071 , G01N33/50 , G01N33/543
摘要： Compositions and methods are provided for biologically relevant in vitro screening of neural function, including determination of the effects of an agent on neural cells. The compositions of the invention useful in such screening methods include a neural co-culture system comprising human pluripotent stem cell (PSC)-derived neurons and human glial cells, which may be derived by culture methods allowing for rapid and robust development of highly mature neuronal activity, particularly spontaneous synchronous network bursts.
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公开(公告)号：US09822338B2
公开(公告)日：2017-11-21
申请号：US14711514
申请日：2015-05-13
IPC分类号： C12N5/0797 , C12N5/071 , C12Q1/68 , C12N5/0793 , C12N5/079 , G01N33/50
CPC分类号： C12N5/0619 , C12N5/0622 , C12N5/0623 , C12N2501/60 , C12N2506/02 , C12N2506/1307 , C12N2506/14 , C12N2506/45 , C12N2510/00 , G01N33/5058
摘要： Methods, compositions and kits for producing functional neurons, astroctyes, oligodendrocytes and progenitor cells thereof are provided. These methods, compositions and kits find use in producing neurons, astrocytes, oligodendrocytes, and progenitor cells thereof for transplantation, for experimental evaluation, as a source of lineage- and cell-specific products, and the like, for example for use in treating human disorders of the CNS. Also provided are methods, compositions and kits for screening candidate agents for activity in converting cells into neuronal cells, astrocytes, oligodendrocytes, and progenitor cells thereof.
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公开(公告)号：US20150284681A1
公开(公告)日：2015-10-08
申请号：US14711514
申请日：2015-05-13
IPC分类号： C12N5/0793 , G01N33/50 , C12N5/079
CPC分类号： C12N5/0619 , C12N5/0622 , C12N5/0623 , C12N2501/60 , C12N2506/02 , C12N2506/1307 , C12N2506/14 , C12N2506/45 , C12N2510/00 , G01N33/5058
摘要： Methods, compositions and kits for producing functional neurons, astroctyes, oligodendrocytes and progenitor cells thereof are provided. These methods, compositions and kits find use in producing neurons, astrocytes, oligodendrocytes, and progenitor cells thereof for transplantation, for experimental evaluation, as a source of lineage- and cell-specific products, and the like, for example for use in treating human disorders of the CNS. Also provided are methods, compositions and kits for screening candidate agents for activity in converting cells into neuronal cells, astrocytes, oligodendrocytes, and progenitor cells thereof.
摘要翻译： 提供了用于产生功能性神经元，星形星，少突胶质细胞和祖细胞的方法，组合物和试剂盒。 这些方法，组合物和试剂盒可用于产生用于移植的神经元，星形胶质细胞，少突胶质细胞和祖细胞，用于实验评价，作为谱系和细胞特异性产物的来源等，例如用于治疗人 中枢神经系统疾病 还提供了用于筛选候选试剂以将细胞转化成神经元细胞，星形胶质细胞，少突胶质细胞和祖细胞的活性的方法，组合物和试剂盒。
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