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公开(公告)号：US20160031947A1
公开(公告)日：2016-02-04
申请号：US14887100
申请日：2015-10-19
IPC分类号： C07K14/28 , C07K14/22 , C07K14/235 , A61K35/13 , A61K49/22 , A61K38/16 , A61K38/10 , A61K38/08 , A61K49/04 , A61K49/14 , C07K14/195 , A61K45/06
CPC分类号： C07K14/28 , A61K35/13 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/164 , A61K45/06 , A61K49/00 , A61K49/04 , A61K49/14 , A61K49/221 , C07K14/195 , C07K14/21 , C07K14/22 , C07K14/235 , C07K2319/02
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer.
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公开(公告)号：US20150374780A1
公开(公告)日：2015-12-31
申请号：US14853761
申请日：2015-09-14
CPC分类号： A61K38/16 , A61K38/00 , A61K38/164 , A61K38/168 , A61K45/06 , C07K14/195 , C07K14/21 , C07K14/22 , C07K14/225 , C07K14/235 , C07K14/28 , C07K14/35 , C07K14/415 , G01N33/5011 , G01N33/5017 , G01N33/569 , G01N2510/00
摘要： The present invention relates to compositions comprising peptides that may be variants, derivatives and structural equivalents of cupredoxins that inhibit the development of premalignant lesions in mammalian cells, tissues and animals. Specifically, these compositions may comprise azurin from Pseudomonas aeruginosa, and/or the 50-77 residue region of azurin (p28). The present invention further relates to compositions that may comprise cupredoxin(s), and/or variants, derivatives or structural equivalents of cupredoxins, that retain the ability to inhibit the development of premalignant lesions in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to prevent the development of premalignant lesions in mammalian cells, tissues and animals, and thus prevent cancer.
摘要翻译： 本发明涉及包含肽的组合物，其可以是抑制哺乳动物细胞，组织和动物中恶化前病变发展的铜氧还蛋白的变体，衍生物和结构等同物。 具体地，这些组合物可以包含来自绿脓假单胞菌的吖啶素和/或吖啶的50-77残基区域（p28）。 本发明还涉及可包含铜氧还蛋白的组合物和/或氧还蛋白的变体，衍生物或结构等同物，其保留抑制哺乳动物细胞，组织或动物中恶化前病变发展的能力。 这些组合物可以是肽或药物组合物等。 本发明的组合物可用于预防哺乳动物细胞，组织和动物中癌前病变的发展，从而预防癌症。
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3.发明授权公开(公告)号：US10889621B2
公开(公告)日：2021-01-12
申请号：US15963605
申请日：2018-04-26
发明人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Yonghua Zhu
IPC分类号： C07K14/21 , A61K38/16 , C07K14/195 , C07K14/705
摘要： The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that interfere with the ephrin signaling system in mammalian cells. Specifically, the invention relates to compositions and methods that use cupredoxins, such as azurin, rusticyanin and plastocyanin, and variants, derivatives and structural equivalents thereof, to treat cancer in mammals.
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公开(公告)号：US10590177B2
公开(公告)日：2020-03-17
申请号：US15969920
申请日：2018-05-03
摘要： The present invention provides modified cupredoxin derived peptides with pharmacologic activity that have improved pharmacokinetic properties, and methods to use them to treat mammals suffering from various conditions related to the pharmacologic activities. Modifications of the cupredoxin derived peptides include amino acid sequence variants and structural derivations that increase the plasma half-life of the peptide, increase the specific activity of the pharmacologic activity, decrease immunogenicity, and decrease the biotransformation of the peptides. The modified cupredoxin derived peptides can be used in methods to treat mammals for cancer, conditions elated to inappropriate angiogenesis, viral and bacterial infections, and specifically HIV and malaria, conditions related to ephrin signaling, and to deliver cargo compounds, including diagnostic compounds, to cancer cells.
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公开(公告)号：US09161989B2
公开(公告)日：2015-10-20
申请号：US14021159
申请日：2013-09-09
IPC分类号： A61K49/00 , A61K39/00 , A61K39/02 , A61K47/48 , C07K14/195 , C07K14/21 , C07K14/22 , A61K35/13 , A61K45/06 , A61K49/04 , A61K49/14 , A61K49/22 , C07K14/235 , C07K14/28 , A61K38/00
CPC分类号： C07K14/28 , A61K35/13 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/164 , A61K45/06 , A61K49/00 , A61K49/04 , A61K49/14 , A61K49/221 , C07K14/195 , C07K14/21 , C07K14/22 , C07K14/235 , C07K2319/02
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer.
摘要翻译： 本发明公开了将货物化合物输送到癌细胞中的方法和材料。 货物化合物的交付是通过使用来自铜氧还蛋白的蛋白质转导结构域完成的。 本发明还公开了治疗癌症和诊断癌症的方法。
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公开(公告)号：US11046733B2
公开(公告)日：2021-06-29
申请号：US15837066
申请日：2017-12-11
IPC分类号： C07K14/195 , C07K14/21 , A61K38/00
摘要： The present invention relates to compositions comprising CpG rich DNA from Pseudomonas aeruginosa. The compositions optionally comprise a cupredoxin. The present invention includes specific CpG DNAs from Pseudomonas aeruginosa that are useful for treating cancer and other conditions in patients. These compositions are optionally in a pharmaceutically acceptable carrier and also optionally comprise a cupredoxin. The present invention further relates to methods to express proteins near cancer cells. These methods may be used to express therapeutic or diagnostic proteins near cancer cells in a patient suffering from cancer or other conditions, and can also be used for diagnosing cancer in a patient. This method uses the gene for azurin from P. aeruginosa as an expression system for azurin or heterologous proteins in P. aeruginosa or heterologous cells.
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公开(公告)号：US20200172581A1
公开(公告)日：2020-06-04
申请号：US15837066
申请日：2017-12-11
IPC分类号： C07K14/195 , C07K14/21
摘要： The present invention relates to compositions comprising CpG rich DNA from Pseudomonas aeruginosa. The compositions optionally comprise a cupredoxin. The present invention includes specific CpG DNAs from Pseudomonas aeruginosa that are useful for treating cancer and other conditions in patients. These compositions are optionally in a pharmaceutically acceptable carrier and also optionally comprise a cupredoxin. The present invention further relates to methods to express proteins near cancer cells. These methods may be used to express therapeutic or diagnostic proteins near cancer cells in a patient suffering from cancer or other conditions, and can also be used for diagnosing cancer in a patient. This method uses the gene for azurin from P. aeruginosa as an expression system for azurin or heterologous proteins in P. aeruginosa or heterologous cells.
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公开(公告)号：US10239920B2
公开(公告)日：2019-03-26
申请号：US14887100
申请日：2015-10-19
IPC分类号： A61K39/00 , A61K39/38 , A61K39/02 , C07K14/28 , C07K14/195 , C07K14/21 , C07K14/22 , A61K35/13 , A61K45/06 , A61K49/04 , A61K49/14 , A61K49/22 , C07K14/235 , A61K38/08 , A61K38/10 , A61K38/16 , A61K49/00 , A61K38/00
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer.
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公开(公告)号：US10117905B2
公开(公告)日：2018-11-06
申请号：US14853761
申请日：2015-09-14
IPC分类号： A61K38/00 , A61K38/16 , C07K14/195 , C07K14/21 , C07K14/35 , C07K14/415 , G01N33/50 , G01N33/569 , C07K14/22 , C07K14/225 , C07K14/235 , C07K14/28 , A61K45/06
摘要： The present invention relates to compositions comprising peptides that may be variants, derivatives and structural equivalents of cupredoxins that inhibit the development of premalignant lesions in mammalian cells, tissues and animals. Specifically, these compositions may comprise azurin from Pseudomonas aeruginosa, and/or the 50-77 residue region of azurin (p28). The present invention further relates to compositions that may comprise cupredoxin(s), and/or variants, derivatives or structural equivalents of cupredoxins, that retain the ability to inhibit the development of premalignant lesions in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to prevent the development of premalignant lesions in mammalian cells, tissues and animals, and thus prevent cancer.
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公开(公告)号：US10058585B2
公开(公告)日：2018-08-28
申请号：US14817063
申请日：2015-08-03
发明人： Anita Chaudhari , Ananda Chakrabarty , Tapas Das Gupta , Arsenio Fialho , Tohru Yamada , Yonghua Zhu
IPC分类号： A61K38/16 , A61K38/00 , C07K14/21 , C07K14/52 , C07K14/705
CPC分类号： A61K38/164 , A61K38/00 , C07K14/21 , C07K14/52 , C07K14/705
摘要： The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that interfere with the ephrin signaling system in mammalian cells. Specifically, the invention relates to compositions and methods that use cupredoxins, such as azurin, rusticyanin and plastocyanin, and variants, derivatives and structural equivalents thereof, to treat cancer in mammals. The invention specifically includes mutants with altered Eph binding constants and selectivities.
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