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公开(公告)号：US10086037B2
公开(公告)日：2018-10-02
申请号：US13561225
申请日：2012-07-30
IPC分类号： A61K38/00 , A61K38/16 , A61K49/00 , A61K49/04 , A61K49/08 , A61K49/14 , C07K14/21 , C07K14/415 , A61M5/00 , C07K14/00 , C07K14/22 , C07K14/225 , C07K14/235 , C07K14/28 , C07K14/32 , C12Q1/02 , C12Q1/04 , A61K47/54 , A61K47/64 , B82Y5/00
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The cargo compound may be a nucleic acid and specifically a DNA, RNA or anti-sense. The invention further discloses methods for treating cancer and diagnosing cancer.
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公开(公告)号：US20100267608A1
公开(公告)日：2010-10-21
申请号：US11853497
申请日：2007-09-11
IPC分类号： A61K38/02 , C07K14/00 , C07K14/21 , C07K14/28 , C07K14/235 , C07K14/22 , C07K14/225 , C07K14/415 , C07K14/195 , C07K2/00 , C07K7/08 , C07K7/06 , A61P35/00 , A61P9/00 , A61P31/12 , A61P31/04 , C12N9/02
CPC分类号： C07K14/21 , A61K38/00 , A61K38/04 , A61K38/08 , A61K38/10 , A61K38/164 , C07K7/00 , Y02A50/395 , Y02A50/411
摘要： The present invention provides modified cupredoxin derived peptides with pharmacologic activity that have improved pharmacokinetic properties, and methods to use them to treat mammals suffering from various conditions related to the pharmacologic activities. Modifications of the cupredoxin derived peptides include amino acid sequence variants and structural derivations that increase the plasma half-life of the peptide, increase the specific activity of the pharmacologic activity, decrease immunogenicity, and decrease the biotransformation of the peptides. The modified cupredoxin derived peptides can be used in methods to treat mammals for cancer, conditions related to inappropriate angiogenesis, viral and bacterial infections, and specifically HIV and malaria, conditions related to ephrin signaling, and to deliver cargo compounds, including diagnostic compounds, to cancer cells.
摘要翻译： 本发明提供具有改善的药代动力学性质的具有药理学活性的改良的铜绿假单胞菌衍生肽以及使用它们治疗患有与药理学活性相关的各种病症的哺乳动物的方法。 铜氧还蛋白衍生肽的修饰包括增加肽的血浆半衰期的氨基酸序列变体和结构衍生物，增加药物活性的比活性，降低免疫原性并降低肽的生物转化。 改良的氧还蛋白衍生肽可用于治疗哺乳动物癌症的方法，与不适当的血管生成，病毒和细菌感染以及特别是HIV和疟疾有关的病症，与ephrin信号传导相关的病症，以及将包括诊断化合物在内的货物化合物递送至 癌细胞。
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公开(公告)号：US10294490B2
公开(公告)日：2019-05-21
申请号：US15274758
申请日：2016-09-23
发明人： Daniel J Altier , Jennifer K Barry , Carol A Hendrick , Lu Liu , Phillip A Patten , Claudia D Perez-Ortega , Eric J Schepers , Weiping Xie , Nasser Yalpani , Jianzhou Zhao , Xiaohong Zhong , Genhai Zhu
IPC分类号： C12N15/82 , C07K14/195 , C07K14/225 , A01N63/02 , A01N37/46
摘要： Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
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公开(公告)号：US10117905B2
公开(公告)日：2018-11-06
申请号：US14853761
申请日：2015-09-14
IPC分类号： A61K38/00 , A61K38/16 , C07K14/195 , C07K14/21 , C07K14/35 , C07K14/415 , G01N33/50 , G01N33/569 , C07K14/22 , C07K14/225 , C07K14/235 , C07K14/28 , A61K45/06
摘要： The present invention relates to compositions comprising peptides that may be variants, derivatives and structural equivalents of cupredoxins that inhibit the development of premalignant lesions in mammalian cells, tissues and animals. Specifically, these compositions may comprise azurin from Pseudomonas aeruginosa, and/or the 50-77 residue region of azurin (p28). The present invention further relates to compositions that may comprise cupredoxin(s), and/or variants, derivatives or structural equivalents of cupredoxins, that retain the ability to inhibit the development of premalignant lesions in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to prevent the development of premalignant lesions in mammalian cells, tissues and animals, and thus prevent cancer.
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公开(公告)号：US09475847B2
公开(公告)日：2016-10-25
申请号：US13800233
申请日：2013-03-13
发明人： Daniel J. Altier , Jennifer K. Barry , Carol A. Hendrick , Lu Liu , Phillip A. Patten , Claudia D. Perez-Ortega , Eric J. Schepers , Weiping Xie , Nasser Yalpani , Jianzhou Zhao , Xiaohong Zhong , Genhai Zhu
IPC分类号： C07K14/225 , A01N37/46 , C07K14/195 , A01N63/02 , C12N15/82
CPC分类号： A01N37/46 , A01N63/02 , C07K14/195 , C07K14/225 , C07K2319/00 , C07K2319/21 , C12N15/8205 , C12N15/8207 , C12N15/8286 , Y02A40/162
摘要： Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
摘要翻译： 提供了控制害虫的组成和方法。 该方法涉及用编码杀虫蛋白的核酸序列转化生物体。 特别地，核酸序列可用于制备具有杀虫活性的植物和微生物。 因此，提供了转化的细菌，植物，植物细胞，植物组织和种子。 组合物是杀虫的核酸和细菌物种的蛋白质。 这些序列用于构建表达载体，用于随后转化为感兴趣的生物体，包括植物，作为分离其他同源（或部分同源的）基因的探针。 杀虫蛋白用于控制，抑制生长或杀死鳞翅目，鞘翅目，双翅目，真菌，半翅目和线虫害虫种群并生产具有杀虫活性的组合物。
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公开(公告)号：US20130084247A1
公开(公告)日：2013-04-04
申请号：US13561225
申请日：2012-07-30
IPC分类号： A61K38/16 , C07K14/32 , C07K14/235 , C07K14/225 , C07K14/22 , C07K14/21 , C07K14/28 , A61K49/00 , A61K49/04 , A61K49/14 , A61K49/22 , C12Q1/02 , C12Q1/04 , A61M5/00 , C07K14/00
CPC分类号： A61K38/164 , A61K38/00 , A61K47/549 , A61K47/64 , A61K49/0002 , A61K49/04 , A61K49/085 , A61K49/14 , A61M5/00 , B82Y5/00 , C07K14/00 , C07K14/21 , C07K14/22 , C07K14/225 , C07K14/235 , C07K14/28 , C07K14/32 , C07K14/415 , C12Q1/025 , C12Q1/04
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The cargo compound may be a nucleic acid and specifically a DNA, RNA or anti-sense. The invention further discloses methods for treating cancer and diagnosing cancer.
摘要翻译： 本发明公开了将货物化合物输送到癌细胞中的方法和材料。 货物化合物的交付是通过使用来自铜氧还蛋白的蛋白质转导结构域完成的。 货物化合物可以是核酸，特别是DNA，RNA或反义词。 本发明还公开了治疗癌症和诊断癌症的方法。
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公开(公告)号：US20120302509A1
公开(公告)日：2012-11-29
申请号：US13555376
申请日：2012-07-23
IPC分类号： A61K38/16 , C12N15/63 , A61P35/00 , C07K7/08 , C07K14/22 , C07K14/21 , C07K14/235 , C07K14/28 , C07K14/225 , C12Q1/02 , C07K7/06
CPC分类号： A61K38/16 , A61K38/00 , A61K38/164 , A61K38/168 , A61K45/06 , C07K14/195 , C07K14/21 , C07K14/22 , C07K14/225 , C07K14/235 , C07K14/28 , C07K14/35 , C07K14/415 , G01N33/5011 , G01N33/5017 , G01N33/569 , G01N2510/00
摘要： The present invention relates to compositions comprising peptides that may be variants, derivatives and structural equivalents of cupredoxins that inhibit the development of premalignant lesions in mammalian cells, tissues and animals. Specifically, these compositions may comprise azurin from Pseudomonas aeruginosa, and/or the 50-77 residue region of azurin (p28). The present invention further relates to compositions that may comprise cupredoxin(s), and/or variants, derivatives or structural equivalents of cupredoxins, that retain the ability to inhibit the development of premalignant lesions in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to prevent the development of premalignant lesions in mammalian cells, tissues and animals, and thus prevent cancer.
摘要翻译： 本发明涉及包含肽的组合物，其可以是抑制哺乳动物细胞，组织和动物中恶化前病变发展的铜氧还蛋白的变体，衍生物和结构等同物。 具体地，这些组合物可以包含来自绿脓假单胞菌的吖啶素和/或吖啶的50-77残基区域（p28）。 本发明还涉及可包含铜氧还蛋白的组合物和/或氧还蛋白的变体，衍生物或结构等同物，其保留抑制哺乳动物细胞，组织或动物中恶化前病变发展的能力。 这些组合物可以是肽或药物组合物等。 本发明的组合物可用于预防哺乳动物细胞，组织和动物中癌前病变的发展，从而预防癌症。
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公开(公告)号：US20120196805A1
公开(公告)日：2012-08-02
申请号：US13405663
申请日：2012-02-27
申请人： Rajeshwari R. Mehta , Brad N. Taylor , Tohru Yamada , Craig W. Beattie , Tapas K. Das Gupta , Ananda M. Chakrabarty
发明人： Rajeshwari R. Mehta , Brad N. Taylor , Tohru Yamada , Craig W. Beattie , Tapas K. Das Gupta , Ananda M. Chakrabarty
IPC分类号： A61K38/16 , C07K14/21 , C07K14/225 , C07K14/235 , C07K14/22 , A61J1/06 , A61P35/00 , A61P37/02 , A61P17/06 , A61P29/00 , C12Q1/02 , C12N15/63 , C07K14/195 , C07K14/28
CPC分类号： A61K38/164 , A01K67/0271 , A01K2207/15 , A01K2227/105 , A01K2267/0331 , A61K38/00 , A61K45/06 , C07K14/21 , G01N33/6893
摘要： The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that accompanies tumor development and particularly in humans. Specifically, the present invention relates to compositions comprising the cupredoxin(s), and or peptides that are variants, derivatives or structural equivalents of cupredoxins, which retain the ability to inhibit angiogenesis in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to treat any pathological condition that has as a symptom or cause, inappropriate angiogenesis, and particularly inappropriate angiogenesis related to tumor development.
摘要翻译： 本发明涉及包含铜氧还蛋白的组合物及其用于抑制哺乳动物细胞，组织和动物中的血管生成，特别是伴随肿瘤发展，特别是人类的血管生成。 具体地说，本发明涉及包含铜氧还蛋白的组合物，和/或作为氧还蛋白的变体，衍生物或结构等同物的肽，其保留抑制哺乳动物细胞，组织或动物中血管生成的能力。 这些组合物可以是肽或药物组合物等。 本发明的组合物可用于治疗作为症状或引起不适当的血管发生以及与肿瘤发展相关的特别不合适的血管生成的任何病理状况。
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公开(公告)号：US5371002A
公开(公告)日：1994-12-06
申请号：US767008
申请日：1991-09-27
IPC分类号： C12N15/09 , C07K14/225 , C12N1/21 , C12N9/00 , C12N15/31 , C12N15/52 , C12N15/53 , C12P7/62 , C12P7/44 , C12P7/52
CPC分类号： C12N9/93 , C07K14/225 , C12N15/52 , C12P7/625
摘要： The invention related to recombinant deoxyribonucleic acid (DNA) technology and, more particularly, to a process whereby poly-beta-hydroxyalkanoate (PHA) copolymers can be synthesized in a recombinant host strain containing the poly-beta-hydroxybutyrate (PHB) biosynthetic genes of Alcaligenes eutrophus.
摘要翻译： 本发明涉及重组脱氧核糖核酸（DNA）技术，更具体地涉及一种可以在含有聚-β-羟基丁酸（PHB）生物合成基因的重组宿主菌株中合成聚-β-羟基链烷酸酯（PHA）共聚物的方法 产碱假单胞菌
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公开(公告)号：US20170006867A1
公开(公告)日：2017-01-12
申请号：US15274758
申请日：2016-09-23
发明人： DANIEL J ALTIER , JENNIFER K BARRY , CAROL A HENDRICK , LU LIU , PHILLIP A PATTEN , CLAUDIA D PEREZ-ORTEGA , ERIC J SCHEPERS , WEIPING XIE , NASSAR YALPANI , JIANZHOU ZHAO , XIAOHONG ZHONG , GENHAI ZHU
IPC分类号： A01N37/46 , A01N63/02 , C12N15/82 , C07K14/225
CPC分类号： C12N15/8286 , A01N37/46 , A01N63/02 , C07K14/195 , C07K14/225 , C07K2319/00 , C07K2319/21 , C12N15/8205 , C12N15/8207 , Y02A40/162
摘要： Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
摘要翻译： 提供了控制害虫的组成和方法。 该方法涉及用编码杀虫蛋白的核酸序列转化生物体。 特别地，核酸序列可用于制备具有杀虫活性的植物和微生物。 因此，提供了转化的细菌，植物，植物细胞，植物组织和种子。 组合物是杀虫的核酸和细菌物种的蛋白质。 这些序列用于构建表达载体，用于随后转化为感兴趣的生物体，包括植物，作为分离其他同源（或部分同源的）基因的探针。 杀虫蛋白用于控制，抑制生长或杀死鳞翅目，鞘翅目，双翅目，真菌，半翅目和线虫害虫种群并生产具有杀虫活性的组合物。
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