公开(公告)号：US20160289276A1

公开(公告)日：2016-10-06

申请号：US15095808

申请日：2016-04-11

申请人： The Board of Trustees of the University of Illinois

发明人： Chang Soo Hong ,  Tohru Yamada ,  Arsenio M. Fialho ,  Tapas K. Das Gupta ,  Ananda M. Chakrabarty

IPC分类号： C07K14/22 ,  A61K38/16 ,  A61K49/00 ,  A61K47/48

CPC分类号： C07K14/22 ,  A61K38/00 ,  A61K47/64

摘要： The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP. The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particular brain cancer.

摘要翻译： 本发明公开了将货物化合物输送到脑癌细胞和/或血脑屏障的方法和材料。 通过使用衍生自奈瑟球菌外膜蛋白质的蛋白质转运肽（例如Laz）来实现货物化合物的递送。 本发明还提供了由五肽AAEAP组成的合成转运肽。 本发明还公开了用于治疗癌症，特别是脑癌以及其他脑相关病症的方法。 此外，本发明提供了成像和诊断癌症，特定脑癌的方法。

公开(公告)号：US10072049B2

公开(公告)日：2018-09-11

申请号：US15095808

申请日：2016-04-11

申请人： The Board of Trustees of the University of Illinois

发明人： Chang Soo Hong ,  Tohru Yamada ,  Arsenio M. Fialho ,  Tapas K. Das Gupta ,  Ananda M. Chakrabarty

IPC分类号： A61K39/00 ,  A61K39/02 ,  A61K39/095 ,  C07K14/22 ,  A61K47/64 ,  A61K38/00

CPC分类号： C07K14/22 ,  A61K38/00 ,  A61K47/64

摘要： The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP. The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particular brain cancer.

公开(公告)号：US09309292B2

公开(公告)日：2016-04-12

申请号：US14041184

申请日：2013-09-30

申请人： The Board of Trustees of the University of Illinois

发明人： Chang Soo Hong ,  Tohru Yamada ,  Arsenio M. Fialho ,  Tapas K. Das Gupta ,  Ananda M. Chakrabarty

IPC分类号： A61K39/095 ,  A61K39/02 ,  A61K39/00 ,  C07K14/22 ,  A61K9/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61K49/08 ,  A61K49/14 ,  A61K49/22 ,  B82Y5/00 ,  C07K7/06 ,  C12N15/62 ,  A61K38/16 ,  A61K45/06 ,  C07K14/47 ,  G01N33/50 ,  A61K38/00

CPC分类号： C07K14/22 ,  A61K9/0085 ,  A61K38/00 ,  A61K38/164 ,  A61K45/06 ,  A61K47/64 ,  A61K47/66 ,  A61K49/0002 ,  A61K49/001 ,  A61K49/0041 ,  A61K49/0056 ,  A61K49/04 ,  A61K49/085 ,  A61K49/14 ,  A61K49/221 ,  B82Y5/00 ,  C07K7/06 ,  C07K14/47 ,  C12N15/625 ,  G01N33/5091

摘要： The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP. The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particular brain cancer.

摘要翻译： 本发明公开了将货物化合物输送到脑癌细胞和/或血脑屏障的方法和材料。 通过使用衍生自奈瑟球菌外膜蛋白质的蛋白质转运肽（例如Laz）来实现货物化合物的递送。 本发明还提供了由五肽AAEAP组成的合成转运肽。 本发明还公开了用于治疗癌症，特别是脑癌以及其他脑相关病症的方法。 此外，本发明提供了成像和诊断癌症，特定脑癌的方法。