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    Modification of cupredoxin derived peptides
    1.
    发明授权
    Modification of cupredoxin derived peptides 有权

    公开(公告)号：US10196428B2

    公开(公告)日：2019-02-05

    申请号：US15232197

    申请日：2016-08-09

    申请人： The Board of Trustees of the University of Illinois

    发明人： Tapas K. Das Gupta ,  Craig W. Beattie

    IPC分类号： C07K14/21 ,  C07K14/195 ,  A61K47/69 ,  A61K47/52 ,  A61K38/16 ,  C07K7/64

    摘要： The present invention provides modified cupredoxin derived peptides with pharmacologic activity that have improved pharmacokinetic properties, and methods to use them to treat mammals suffering from various conditions related to the pharmacologic activities. Modifications of the cupredoxin derived peptides include amino acid sequence variants and structural derivations that increase the plasma half-life of the peptide, increase the specific activity of the pharmacologic activity, decrease immunogenicity, and decrease the biotransformation of the peptides. The modified cupredoxin derived peptides can be used in methods to treat mammals for cancer, conditions related to inappropriate angiogenesis, viral and bacterial infections, and specifically HIV and malaria, conditions related to ephrin signaling, and to deliver cargo compounds, including diagnostic compounds to cancer cell.

    TRANSPORT AGENTS FOR CROSSING THE BLOOD-BRAIN BARRIER AND INTO BRAIN CANCER CELLS, AND METHODS OF USE THEREOF
    2.
    发明申请
    TRANSPORT AGENTS FOR CROSSING THE BLOOD-BRAIN BARRIER AND INTO BRAIN CANCER CELLS, AND METHODS OF USE THEREOF 审中-公开
    用于交叉血脑屏障和脑癌细胞的运输代理及其使用方法

    公开(公告)号：US20160289276A1

    公开(公告)日：2016-10-06

    申请号：US15095808

    申请日：2016-04-11

    申请人： The Board of Trustees of the University of Illinois

    发明人： Chang Soo Hong ,  Tohru Yamada ,  Arsenio M. Fialho ,  Tapas K. Das Gupta ,  Ananda M. Chakrabarty

    IPC分类号： C07K14/22 ,  A61K38/16 ,  A61K49/00 ,  A61K47/48

    CPC分类号： C07K14/22 ,  A61K38/00 ,  A61K47/64

    摘要： The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP. The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particular brain cancer.

    摘要翻译： 本发明公开了将货物化合物输送到脑癌细胞和/或血脑屏障的方法和材料。 通过使用衍生自奈瑟球菌外膜蛋白质的蛋白质转运肽（例如Laz）来实现货物化合物的递送。 本发明还提供了由五肽AAEAP组成的合成转运肽。 本发明还公开了用于治疗癌症，特别是脑癌以及其他脑相关病症的方法。 此外，本发明提供了成像和诊断癌症，特定脑癌的方法。