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    METHODS OF TREATING CYTOKINE RELEASE SYNDROME
    2.
    发明申请
    METHODS OF TREATING CYTOKINE RELEASE SYNDROME 有权

    公开(公告)号：US20220218652A1

    公开(公告)日：2022-07-14

    申请号：US17273646

    申请日：2019-09-05

    Applicant: The General Hospital Corporation ,  AZTherapies, Inc.

    Inventor： David R. Elmaleh ,  Rudolph E. Tanzi ,  Ana Griciuc ,  Robert Warren ,  Karen Reeves

    IPC: A61K31/352 ,  A61P37/06 ,  A61K45/06 ,  A61K38/17

    Abstract: The present disclosure relates to a method of treating at least one Cell-Associated Neurotoxicity Syndrome (ICANS), cancer-related cognitive impairment, Infusion Reaction Syndrome (IRS), Capillary Leak Syndrome (CLS), Tumor Lysis Syndrome (TLS), Macrophage Activation Syndrome (MAS), Systemic Inflammatory Response Syndrome (SIRS), Immune Reconstitution Inflammatory Syndrome (IRIS), Graft-Versus-Host Disease (GVHD), Acute Respiratory Distress Syndrome (ARDS), sepsis, Ebola, avian influenza, smallpox, Systemic Inflammatory Response Syndrome (SIRS), and Immune-related Adverse Events Syndrome (IrAES) in a subject in need thereof, comprising administering a mast cell stabilizer or a compound of Formula I or Formula II: Formula I, Formula II, wherein R1 is halogen, OH, or —OC(O)C1-5alkyl R2 and R3 are each independently selected from CO2R4 or CH2OR5; R4 is i L, Na, K, H, C1-5alkyl, or —CH2CO(C1-5alkyl); and R5 is H or C(O)(C1-5alkyl), or a pharmaceutically acceptable salt thereof.

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