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1.发明申请HYBRID SCFA-HYDROXYL-DERIVATIZED MONOSACCHARIDES, METHODS OF SYNTHESIS, AND METHODS OF TREATING DISORDERS 审中-公开HYBRID SCFA-羟基衍生的单糖，合成方法和治疗疾病的方法公开(公告)号：US20160151400A1
公开(公告)日：2016-06-02
申请号：US14755539
申请日：2015-06-30
发明人： Kevin J. Yarema , Udayanath Aich , Christopher T. Campbell , Srinivasa-Gopalan Sampathkumar , Sean S. Choi , Michael A. Meledeo , Christopher Weier
IPC分类号： A61K31/7008 , A61K31/7028 , G01N33/50 , C07H13/04 , A61K31/7012 , A61K45/06 , C07H15/04 , C07H5/06
CPC分类号： A61K31/7008 , A61K31/7012 , A61K31/7028 , A61K45/06 , C07H5/06 , C07H7/027 , C07H13/04 , C07H15/04 , G01N33/5091
摘要： Described herein are fatty acid carbohydrate-hydroxyl-hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
摘要翻译： 本文描述的是脂肪酸碳水化合物 - 羟基 - 杂合化合物及其衍生物，以及使用该化合物及其组合物治疗或预防疾病和疾病症状的方法。
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公开(公告)号：US10899784B2
公开(公告)日：2021-01-26
申请号：US15503911
申请日：2015-08-14
IPC分类号： A61K31/7008 , A61K31/7024 , C07H13/04 , A61K45/06 , A61K31/35 , C07H13/08 , C12Q1/48
摘要： Disclosed are UAP inhibitors to inhibit glucose flux in the hexosamine biosynthetic pathway and methods of treating a disease using the inhibitors.
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3.发明申请USE OF HIGH FLUX SCFA-DERIVATIZED MONOSACCHARIDES IN RECOMBINANT GLYCOPROTEIN PRODUCTION 审中-公开在重组蛋白生产中使用高通量SCFA衍生的单糖公开(公告)号：US20150191761A1
公开(公告)日：2015-07-09
申请号：US14593499
申请日：2015-01-09
CPC分类号： C12P21/005 , C07K14/61 , C07K16/00 , C07K2317/14 , C07K2317/41 , C12N9/18 , C12Y301/01008 , G01N33/68
摘要： Methods of glycoprotein production employing monosaccharides capable of producing a global increase in flux through the sialic acid pathway are provided.
摘要翻译： 提供使用能够通过唾液酸途径产生通量增加的单糖的糖蛋白生产方法。
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公开(公告)号：US20240279328A1
公开(公告)日：2024-08-22
申请号：US18013864
申请日：2021-07-02
发明人： Kevin J. Yarema , Christian Agatemor , Christopher T. Saeui , Matthew Buettner , Jamie SPANGLER , Seth Ludwig , Riddhima Dennar Chitre , Kris Dammem-Brower , Zachary BERNSTEIN
CPC分类号： C07K16/246 , A61P35/00 , C12N9/1081 , C12N9/1085 , C12N9/2402 , C12N9/88 , C12N9/90 , C12N15/52 , A61K2039/505 , C07K2317/14 , C07K2317/41 , C12Y204/01 , C12Y205/01057 , C12Y302/01018 , C12Y401/03003 , C12Y501/03008
摘要： Compositions for producing glycoengineered proteins, e.g. antibodies, include host cells which lack the ability to produce enzymes that modulate sialic acid metabolic flux.
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公开(公告)号：US11015215B2
公开(公告)日：2021-05-25
申请号：US14593499
申请日：2015-01-09
摘要： Methods of glycoprotein production employing monosaccharides capable of producing a global increase in flux through the sialic acid pathway are provided.
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公开(公告)号：US20180148468A1
公开(公告)日：2018-05-31
申请号：US15503911
申请日：2015-08-14
IPC分类号： C07H13/04 , A61K31/7024 , A61K45/06 , C12Q1/48
CPC分类号： C07H13/04 , A61K31/35 , A61K31/7024 , A61K45/06 , C07H13/08 , C12Q1/485 , C12Y207/07023 , C12Y207/07083 , G01N2333/9125 , G01N2500/04 , G01N2500/10 , G01N2500/20
摘要： Disclosed are UAP inhibitors to inhibit glucose flux in the hexosamine biosynthetic pathway and methods of treating a disease using the inhibitors.
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公开(公告)号：US11827663B2
公开(公告)日：2023-11-28
申请号：US17127979
申请日：2020-12-18
IPC分类号： A61K31/7008 , A61K31/7024 , C07H13/04 , A61K45/06 , A61K31/35 , C07H13/08 , C12Q1/48
CPC分类号： C07H13/04 , A61K31/35 , A61K31/7024 , A61K45/06 , C07H13/08 , C12Q1/485 , C12Y207/07023 , C12Y207/07083 , G01N2333/9125 , G01N2500/04 , G01N2500/10 , G01N2500/20
摘要： Disclosed are UAP inhibitors to inhibit glucose flux in the hexosamine biosynthetic pathway and methods of treating a disease using the inhibitors.
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8.发明授权Hybrid SCFA-hydroxyl-derivatized monosaccharides, methods of synthesis, and methods of treating disorders 有权杂交SCFA-羟基衍生的单糖，合成方法和治疗疾病的方法公开(公告)号：US09067960B2
公开(公告)日：2015-06-30
申请号：US14246809
申请日：2014-04-07
发明人： Kevin J. Yarema , Udayanath Aich , Christopher T. Campbell , Srinivasa-Gopalan Sampathkumar , Sean S. Choi , Michael A. Meledeo , Christopher Weier
CPC分类号： A61K31/7008 , A61K31/7012 , A61K31/7028 , A61K45/06 , C07H5/06 , C07H7/027 , C07H13/04 , C07H15/04 , G01N33/5091
摘要： Described herein are fatty acid carbohydrate-hydroxyl-hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
摘要翻译： 本文描述的是脂肪酸碳水化合物 - 羟基 - 杂合化合物及其衍生物，以及使用该化合物及其组合物治疗或预防疾病和疾病症状的方法。
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9.发明申请HYBRID SCFA-HYDROXYL-DERIVATIZED MONOSACCHARIDES, METHODS OF SYNTHESIS, AND METHODS OF TREATING DISORDERS 有权HYBRID SCFA-羟基衍生的单糖，合成方法和治疗疾病的方法公开(公告)号：US20140220630A1
公开(公告)日：2014-08-07
申请号：US14246809
申请日：2014-04-07
发明人： Kevin J. Yarema , Udayanath Aich , Christopher T. Campbell , Srinivasa-Gopalan Sampathkumar , Sean S. Choi , Michael A. Meledeo , Christopher Weier
IPC分类号： C07H13/04
CPC分类号： A61K31/7008 , A61K31/7012 , A61K31/7028 , A61K45/06 , C07H5/06 , C07H7/027 , C07H13/04 , C07H15/04 , G01N33/5091
摘要： Described herein are fatty acid carbohydrate-hydroxyl-hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
摘要翻译： 本文描述的是脂肪酸碳水化合物 - 羟基 - 杂合化合物及其衍生物，以及使用该化合物及其组合物治疗或预防疾病和疾病症状的方法。
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公开(公告)号：US20210269468A1
公开(公告)日：2021-09-02
申请号：US17127979
申请日：2020-12-18
摘要： Disclosed are UAP inhibitors to inhibit glucose flux in the hexosamine biosynthetic pathway and methods of treating a disease using the inhibitors.
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