公开(公告)号：US20240327449A1

公开(公告)日：2024-10-03

申请号：US18579766

申请日：2022-07-22

Applicant: The Regents of the University of California

Inventor： Feng Guo ,  Vaithilingaraja Arumugaswami

IPC: C07H21/04 ,  C12N15/113

CPC classification number: C07H21/04 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3233

Abstract: This invention provides a structure-based design method for making antisense oligonucleotides (ASOs) and ASOs made by this method. ASOs are an emerging class of drugs that are especially suitable for fighting a wide range of diseases. They are single-stranded synthetic oligonucleotides that specifically bind target RNAs and elicit desired biological and therapeutic effects. Conventional ASO design strategies do not adequately address this problem. The instant invention includes structure-based ASO designs that target RNAs critical in a variety of diseases.

公开(公告)号：US20240252619A1

公开(公告)日：2024-08-01

申请号：US18560515

申请日：2022-05-20

Applicant: The Regents of the University of California

Inventor： Vaithilingaraja Arumugaswami ,  Gustavo Garcia Jr. ,  Kouki Morizono

IPC: A61K39/215 ,  A61K39/00 ,  A61P31/14 ,  C12N7/00

CPC classification number: A61K39/215 ,  A61P31/14 ,  C12N7/00 ,  A61K2039/5254 ,  C12N2770/20034 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24143 ,  C12N2830/50 ,  C12N2830/52

Abstract: Disclosed herein are nucleic acid constructs comprising a replication defective Zika virus vector and one or more coronavirus sequences and compositions thereof. The constructs relates to compositions and methods for inducing an immune response against coronavirus antigens due to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak. The results herein indicate that these coronavirus constructs are safe and will induce an immune response that may provide protection against coronaviruses.

公开(公告)号：US20220213504A1

公开(公告)日：2022-07-07

申请号：US17609496

申请日：2020-05-20

Applicant: The Regents of the University of California

Inventor： Vaithilingaraja Arumugaswami ,  Gustavo Garcia, JR. ,  David A. Nathanson ,  Ren Sun

IPC: C12N15/86 ,  C07K14/005 ,  A61K39/00 ,  A61P35/00

Abstract: Disclosed herein are Zika virus constructs and methods of using Zika virus constructs and Zika viruses to treat subjects in need thereof.

公开(公告)号：US20250090557A1

公开(公告)日：2025-03-20

申请号：US18004556

申请日：2021-07-08

Applicant: The Regents of the University of California

Inventor： Theodoros Kelesidis ,  Vaithilingaraja Arumugaswami ,  Gustavo Garcia Jr.

IPC: A61K31/66 ,  A61K45/06

Abstract: Disclosed herein are methods of using one or more mitochondrial targeted antioxidants, such as mitoquinol or mitoquinone, to prevent, inhibit, and/or treat infections and symptoms caused by infection by a coronavirus, such as SARS-CoV-2.

公开(公告)号：US20230190736A1

公开(公告)日：2023-06-22

申请号：US17917445

申请日：2021-04-09

Applicant: The Regents of the University of California

Inventor： Vaithilingaraja Arumugaswami ,  Heather R. Christofk ,  Robert Damoiseaux ,  Gustavo Garcia ,  Peter Mullen ,  Brigitte N. Gomperts

IPC: A61K31/497 ,  A61K45/06 ,  A61P31/14 ,  A61K31/5377 ,  A61K31/436 ,  A61K31/4706

CPC classification number: A61K31/497 ,  A61K45/06 ,  A61P31/14 ,  A61K31/5377 ,  A61K31/436 ,  A61K31/4706

Abstract: This disclosure relates to methods of treating viral infections, such as influenza or coronavirus, with certain inhibitors, such as kinase inhibitors.

公开(公告)号：US20230174946A1

公开(公告)日：2023-06-08

申请号：US17922162

申请日：2021-04-30

Applicant: CEDARS-SINAI MEDICAL CENTER ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Barry R. Stripp ,  Apoorva Mulay ,  Bindu Konda ,  Arun Sharma ,  Clive Svendsen ,  Vaithilingaraja Arumugaswami ,  Dhruv Sareen ,  Hanan Shaharuddin ,  Victoria Wang ,  Roberta S. Santos

IPC: C12N5/071 ,  C12N5/077 ,  C12M3/06

CPC classification number: C12N5/0676 ,  C12M23/16 ,  C12N5/0657 ,  C12N5/0688 ,  C12N2503/02 ,  C12N2506/45

Abstract: Described herein are particular infection model systems, methods of studying infection, and method of screening compounds in various model systems. Particularly, SARS-CoV-2 is studied in these organ and infection models.

公开(公告)号：US20220273678A1

公开(公告)日：2022-09-01

申请号：US17570737

申请日：2022-01-07

Applicant: The Regents of the University of California

Inventor： Theodoros Kelesidis ,  Vaithilingaraja Arumugaswami ,  Gustavo Garcia, JR.

IPC: A61K31/66 ,  A61P31/14 ,  A61K38/10

Abstract: Disclosed herein are methods of using one or more triphenylphosphonium compounds, to prevent, inhibit, and/or treat infections and symptoms caused by infection by a coronavirus, such as SARS-CoV-2.