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公开(公告)号：US20190302000A1
公开(公告)日：2019-10-03
申请号：US16307449
申请日：2017-06-09
Applicant: The Regents of the University of California
Inventor： Yu-Hwa Lo , Yuanyuan Han , Yi Gu , Ce Zhang
Abstract: Disclosed are systems, devices and methods for imaging and image-based sorting of particles in a flow system, including cells in a flow cytometer. In some aspects, a system includes a particle flow device to flow particles through a channel, an imaging system to obtain image data of a particle during flow through the channel, a processing unit to determine a property associated with the particle and to produce a control command for sorting the particle based on sorting criteria associated with particle properties, and an actuator to direct the particle into one of a plurality of output paths of the particle flow device in real-time.
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公开(公告)号：US11668641B2
公开(公告)日：2023-06-06
申请号：US17326312
申请日：2021-05-20
Applicant: The Regents of the University of California
Inventor： Yu-Hwa Lo , Yuanyuan Han , Yi Gu , Ce Zhang
CPC classification number: G01N15/1475 , G01J3/0208 , G01J3/0229 , G01J3/36 , G01J3/4406 , G01J3/46 , G01J3/51 , G01N15/147 , G01N15/1429 , G01N15/1484 , G01N2015/1006 , G01N2015/1402 , G01N2015/149 , G01N2015/1497
Abstract: Disclosed are systems, devices and methods for imaging and image-based sorting of particles in a flow system, including cells in a flow cytometer. In some aspects, a system includes a particle flow device to flow particles through a channel, an imaging system to obtain image data of a particle during flow through the channel, a processing unit to determine a property associated with the particle and to produce a control command for sorting the particle based on sorting criteria associated with particle properties, and an actuator to direct the particle into one of a plurality of output paths of the particle flow device in real-time.
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3.发明申请公开(公告)号：US20190094166A1
公开(公告)日：2019-03-28
申请号：US16083424
申请日：2017-03-09
Applicant: The Regents of the University of California
Inventor： Yu-Hwa Lo , Tiantian Zhang , Ti-Hsuan Ku , Yuanyuan Han
IPC: G01N27/00 , B01L3/00 , G01N33/557 , G01N33/543
Abstract: Methods, systems, and devices are disclosed for studying physical or chemical properties of molecules, and/or interactions between molecules such as protein-ligand interactions. The methods, systems, and devices involve transient induced molecular electronic spectroscopy (TIMES). In some configuration, a microfluidic channel having at least one inlet and at least one outlet is used for holding molecules for analyzing the molecules or interactions between molecules.
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公开(公告)号：US20230384208A1
公开(公告)日：2023-11-30
申请号：US18295244
申请日：2023-04-03
Applicant: The Regents of the University of California
Inventor： Yu-Hwa Lo , Yuanyuan Han , Yi Gu , Ce Zhang
CPC classification number: G01N15/1475 , G01J3/51 , G01N15/1429 , G01N15/147 , G01N15/1484 , G01J3/0229 , G01J3/36 , G01J3/0208 , G01J3/46 , G01J3/4406 , G01N2015/1006
Abstract: Disclosed are systems, devices and methods for imaging and image-based sorting of particles in a flow system, including cells in a flow cytometer. In some aspects, a system includes a particle flow device to flow particles through a channel, an imaging system to obtain image data of a particle during flow through the channel, a processing unit to determine a property associated with the particle and to produce a control command for sorting the particle based on sorting criteria associated with particle properties, and an actuator to direct the particle into one of a plurality of output paths of the particle flow device in real-time.
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公开(公告)号：US11371929B2
公开(公告)日：2022-06-28
申请号：US16970304
申请日：2019-02-19
Applicant: The Regents of the University of California
Inventor： Yu-Hwa Lo , Yuanyuan Han
IPC: H04N13/254 , G01N15/14 , G01N15/10
Abstract: Disclosed are methods, devices, systems and applications for camera-less, high-throughput three-dimensional imaging of particles in motion. In some aspects, a system includes a particle motion device to allow particles to move along a travel path; an optical illumination system to produce an asymmetric illumination area of light in a region of the travel path of a particle that scans over a plurality of sections of the particle at multiple time points while the particle is moving; an optical detection system optically interfaced with the particle motion device to obtain optical signal data associated with different parts of the particle corresponding to the particle's volume during motion in the travel path; and a data processing unit to process the optical signal data obtained by the optical detection system and produce data including information indicative of 3D features of the particle.
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Patent Agency Ranking
公开(公告)号：US11016017B2
公开(公告)日：2021-05-25
申请号：US16307449
申请日：2017-06-09
Applicant: The Regents of the University of California
Inventor： Yu-Hwa Lo , Yuanyuan Han , Yi Gu , Ce Zhang
Abstract: Disclosed are systems, devices and methods for imaging and image-based sorting of particles in a flow system, including cells in a flow cytometer. In some aspects, a system includes a particle flow device to flow particles through a channel, an imaging system to obtain image data of a particle during flow through the channel, a processing unit to determine a property associated with the particle and to produce a control command for sorting the particle based on sorting criteria associated with particle properties, and an actuator to direct the particle into one of a plurality of output paths of the particle flow device in real-time.
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公开(公告)号：US10788425B2
公开(公告)日：2020-09-29
申请号：US16367071
申请日：2019-03-27
Applicant: The Regents of the University of California
Inventor： Yu-Hwa Lo , Yuanyuan Han
Abstract: Methods, systems, and devices are disclosed for imaging particles and/or cells using flow cytometry. In one aspect, a method includes transmitting a light beam at a fluidic channel carrying a fluid sample containing particles; optically encoding scattered or fluorescently-emitted light at a spatial optical filter, the spatial optical filter including a surface having a plurality of apertures arranged in a pattern along a transverse direction opposite to particle flow and a longitudinal direction parallel to particle flow, such that different portions of a particle flowing over the pattern of the apertures pass different apertures at different times and scatter the light beam or emit fluorescent light at locations associated with the apertures; and producing image data associated with the particle flowing through the fluidic channel based on the encoded optical signal, in which the produced image data includes information of a physical characteristic of the particle.
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公开(公告)号：US12152992B2
公开(公告)日：2024-11-26
申请号：US18455148
申请日：2023-08-24
Applicant: The Regents of the University of California
Inventor： Yu-Hwa Lo , Yuanyuan Han
IPC: G01N21/64 , G01N15/14 , G01N15/1434 , G01N21/51 , G01N21/53 , G01F17/00 , G01N15/10 , G02B21/00
Abstract: Methods, systems, and devices are disclosed for imaging particles and/or cells using flow cytometry. In one aspect, a method includes transmitting a light beam at a fluidic channel carrying a fluid sample containing particles; optically encoding scattered or fluorescently-emitted light at a spatial optical filter, the spatial optical filter including a surface having a plurality of apertures arranged in a pattern along a transverse direction opposite to particle flow and a longitudinal direction parallel to particle flow, such that different portions of a particle flowing over the pattern of the apertures pass different apertures at different times and scatter the light beam or emit fluorescent light at locations associated with the apertures; and producing image data associated with the particle flowing through the fluidic channel based on the encoded optical signal, in which the produced image data includes information of a physical characteristic of the particle.
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公开(公告)号：US20220011216A1
公开(公告)日：2022-01-13
申请号：US17326312
申请日：2021-05-20
Applicant: The Regents of the University of California
Inventor： Yu-Hwa Lo , Yuanyuan Han , Yi Gu , Ce Zhang
Abstract: Disclosed are systems, devices and methods for imaging and image-based sorting of particles in a flow system, including cells in a flow cytometer. In some aspects, a system includes a particle flow device to flow particles through a channel, an imaging system to obtain image data of a particle during flow through the channel, a processing unit to determine a property associated with the particle and to produce a control command for sorting the particle based on sorting criteria associated with particle properties, and an actuator to direct the particle into one of a plurality of output paths of the particle flow device in real-time.
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公开(公告)号：US20210181113A1
公开(公告)日：2021-06-17
申请号：US17035505
申请日：2020-09-28
Applicant: The Regents of the University of California
Inventor： Yu-Hwa Lo , Yuanyuan Han
Abstract: Methods, systems, and devices are disclosed for imaging particles and/or cells using flow cytometry. In one aspect, a method includes transmitting a light beam at a fluidic channel carrying a fluid sample containing particles; optically encoding scattered or fluorescently-emitted light at a spatial optical filter, the spatial optical filter including a surface having a plurality of apertures arranged in a pattern along a transverse direction opposite to particle flow and a longitudinal direction parallel to particle flow, such that different portions of a particle flowing over the pattern of the apertures pass different apertures at different times and scatter the light beam or emit fluorescent light at locations associated with the apertures; and producing image data associated with the particle flowing through the fluidic channel based on the encoded optical signal, in which the produced image data includes information of a physical characteristic of the particle.
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