公开(公告)号：US20240336936A1

公开(公告)日：2024-10-10

申请号：US18680137

申请日：2024-05-31

申请人： LONZA WALKERSVILLE, INC.

发明人： Young SHIN ,  Anandita SETH ,  Bingnan GU

IPC分类号： C12N15/867 ,  C07K14/16 ,  C12N5/071 ,  C12N9/12 ,  C12N15/86

CPC分类号： C12N15/867 ,  C07K14/161 ,  C07K14/162 ,  C07K14/163 ,  C12N5/0686 ,  C12N9/1241 ,  C12N15/8673 ,  C12N15/8676 ,  C12N15/86 ,  C12N2740/15051 ,  C12N2740/16052 ,  C12N2760/20222

摘要： The present disclosure relates to methods for producing lentiviral vector-producing cells. Specifically the methods utilize two plasmids, rather than four, to provide the required packaging elements and transfer vector to a cell, allowing for the production of a large number of lentiviral producer cells, including suspension-based cells, and the production of high amounts of lentivirus. These methods allow for the production of cells that can be later induced to produce lentivirus, and can be tailored to include a specific gene of interest.

公开(公告)号：US12053520B2

公开(公告)日：2024-08-06

申请号：US17587817

申请日：2022-01-28

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Xuejun Chen ,  Jeffrey Boyington ,  Hongying Duan Holdsworth ,  Cheng Cheng ,  John R. Mascola

IPC分类号： A61K39/21 ,  C07K14/005 ,  C07K14/16 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/21 ,  C07K14/005 ,  C07K14/162 ,  C12N7/00 ,  C12Y205/01078 ,  A61K2039/5258 ,  A61K2039/55555 ,  C07K2319/00 ,  C12N2740/16023 ,  C12N2740/16043 ,  C12N2740/16111 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16171

摘要： Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.

公开(公告)号：US11767347B2

公开(公告)日：2023-09-26

申请号：US17553070

申请日：2021-12-16

申请人： The Scripps Research Institute

发明人： Leopold Kong ,  Ian A. Wilson ,  Natalia De Val ,  Andrew B. Ward ,  Dennis Burton ,  Linling He ,  Jiang Zhu

IPC分类号： C07K14/16 ,  A61K47/69 ,  A61K39/21 ,  C07K14/005 ,  A61K39/12 ,  A61K47/64 ,  A61K39/00

CPC分类号： C07K14/162 ,  A61K39/21 ,  A61K47/6929 ,  C07K14/005 ,  A61K39/12 ,  A61K47/64 ,  A61K2039/5258 ,  A61K2039/6031 ,  A61K2039/645 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.

公开(公告)号：US20230181717A1

公开(公告)日：2023-06-15

申请号：US17550768

申请日：2021-12-14

申请人： THE SCRIPPS RESEARCH INSTITUTE

发明人： Linling He ,  Jiang Zhu

IPC分类号： A61K39/21 ,  A61K47/69 ,  A61P31/18 ,  A61K9/51 ,  A61K38/16 ,  C07K14/16

CPC分类号： A61K39/21 ,  A61K47/6929 ,  A61P31/18 ,  A61K9/51 ,  A61K38/162 ,  C07K14/162 ,  A61K2039/55516

摘要： The present invention provides methods for producing HIV-1 nanoparticle vaccines with enhanced immunogenicity. The methods entail (1) enzymatic digestion of glycan chain on the surface of a self-assembling nanoparticle vaccine displaying an HIV-1 Env derived trimer immunogen, or (2) expression of an HIV-1 nanoparticle construct in an expression system lacking normal glycosylation function for human proteins. Also provided in the invention are HIV-1 nanoparticle vaccines produced with the described methods. The invention further provides methods of using the HIV-1 nanoparticle vaccine compositions described herein in various therapeutic applications, e.g., for preventing or treating viral infections.

公开(公告)号：US20170165355A1

公开(公告)日：2017-06-15

申请号：US15380123

申请日：2016-12-15

申请人： Janssen Vaccines & Prevention B.V.

发明人： Johannes Petrus Maria LANGEDIJK

IPC分类号： A61K39/21 ,  C12N7/00 ,  C07K14/005 ,  C12N15/86

CPC分类号： A61K39/21 ,  A61K2039/5256 ,  C07K14/005 ,  C07K14/162 ,  C12N7/00 ,  C12N15/86 ,  C12N15/861 ,  C12N2710/10343 ,  C12N2740/16111 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16171

摘要： Synthetic HIV envelope proteins, vectors and compositions thereof, and methods for inducing protective immunity against human immunodeficiency virus (HIV) infection are described. Viral expression vectors encoding the synthetic HIV envelope proteins can be used in vaccines to provide improved protective immunity against HIV.

公开(公告)号：US09636396B2

公开(公告)日：2017-05-02

申请号：US13707885

申请日：2012-12-07

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE PARIS-SUD XI ,  INSTITUT GUSTAVE ROUSSY ,  VIROXIS S.A.S.

发明人： Thierry Heidmann

IPC分类号： A61K39/21 ,  C07K14/16 ,  C07K7/06 ,  C07K7/08 ,  C07K14/005 ,  A61K39/12

CPC分类号： A61K39/12 ,  A61K39/21 ,  C07K7/06 ,  C07K7/08 ,  C07K14/005 ,  C07K14/162 ,  C12N2740/15022 ,  C12N2740/15033 ,  C12N2740/15034 ,  C12N2740/16022 ,  C12N2740/16034 ,  C12N2740/16111 ,  C12N2740/16122 ,  C12N2740/16134

摘要： A pharmaceutical composition includes, as active substance a mutated lentiviral ENV protein, substantially devoid of immunosuppressive properties or a variant of the mutated lentiviral ENV protein or a fragment of the above proteins, in association with a pharmaceutically acceptable carrier.

公开(公告)号：US20170035877A1

公开(公告)日：2017-02-09

申请号：US14508369

申请日：2014-10-07

申请人： International AIDS Vaccine Initiative ,  The Scripps Research Institute

发明人： Richard Wyatt ,  Andrew Ward ,  Karen Tran ,  Shailendra Kumar ,  Jidnyasa Ingale ,  Javier Guenaga ,  Yu Feng ,  Viktoria Dubrowskaya ,  Natalia de Val Alta

IPC分类号： A61K39/21 ,  C07K14/005 ,  C12N7/00

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/645 ,  C07K14/005 ,  C07K14/162 ,  C12N7/00 ,  C12N2740/16022 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present application relates to novel HIV-1 envelope glycoproteins which may be utilized as an HIV-1 vaccine immunogens, antigens for crystallization and for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.

摘要翻译： 本申请涉及可用作HIV-1疫苗免疫原的新型HIV-1包膜糖蛋白，用于结晶的抗原和用于鉴定广泛的中和抗体。 本发明包括配制成本发明疫苗的免疫原性组合物的制备和纯化。

公开(公告)号：US09249427B2

公开(公告)日：2016-02-02

申请号：US13694280

申请日：2012-11-14

申请人： OREGON HEALTH & SCIENCE UNIVERSITY

发明人： Louis Picker ,  Jay A. Nelson ,  Klaus Frueh ,  Michael A. Jarvis ,  Scott G. Hansen

IPC分类号： A61K39/21 ,  C12N15/63 ,  A61P31/18 ,  C12N15/38 ,  C12N15/48 ,  C12N15/49 ,  C07K14/045 ,  C07K14/16 ,  C12N15/869 ,  A61K39/12 ,  C12N15/86 ,  A61K39/00 ,  A61K39/08 ,  A61K39/13 ,  A61K39/145 ,  A61K39/275

CPC分类号： A61K39/12 ,  A61K39/0011 ,  A61K39/08 ,  A61K39/13 ,  A61K39/145 ,  A61K39/21 ,  A61K39/275 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/572 ,  A61K2039/58 ,  C07K14/005 ,  C07K14/045 ,  C07K14/16 ,  C07K14/161 ,  C07K14/162 ,  C07K14/163 ,  C12N7/00 ,  C12N15/86 ,  C12N15/869 ,  C12N2710/16111 ,  C12N2710/16134 ,  C12N2710/16141 ,  C12N2710/16143 ,  C12N2710/16162 ,  C12N2710/16171 ,  C12N2710/24134 ,  C12N2730/10134 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/16034 ,  C12N2760/14134 ,  C12N2760/16134 ,  C12N2770/32634 ,  Y02A50/383 ,  Y02A50/386 ,  Y02A50/412 ,  Y02A50/466

摘要： The present invention relates to recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens, which may be used, for example, for the treatment or prevention of infectious disease or cancer. The recombinant RhCMV or HCMV vectors elicit and maintain high level cellular immune responses specific for the heterologous antigen while including deletions in one or more genes essential or augmenting for CMV replication, dissemination or spread.

摘要翻译： 本发明涉及编码异源抗原如病原体特异性抗原或肿瘤抗原的重组恒河猴巨细胞病毒（RhCMV）和人巨细胞病毒（HCMV）载体，其可用于例如治疗或预防感染性疾病或癌症 。 重组RhCMV或HCMV载体引发并保持对异源抗原特异性的高水平细胞免疫应答，同时包括在一个或多个重要或增强CMV复制，传播或扩散的基因中的缺失。

公开(公告)号：US20150239933A1

公开(公告)日：2015-08-27

申请号：US14630246

申请日：2015-02-24

申请人： GEORGETOWN UNIVERSITY

发明人： Italo MOCCHETTI ,  Valeriya AVDOSHINA

IPC分类号： C07K7/08 ,  C07K14/00

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K14/00 ,  C07K14/005 ,  C07K14/162 ,  C12N2740/16033 ,  C12N2740/16122 ,  C12N2740/16134

摘要： Peptides and peptide analogs that competitively inhibit HIV protein gp120 and methods for making and using the same.

摘要翻译： 竞争性抑制HIV蛋白gp120的肽和肽类似物及其制备和使用方法。

公开(公告)号：US20140335126A1

公开(公告)日：2014-11-13

申请号：US14363131

申请日：2012-12-05

申请人： DUKE UNIVERSITY ,  THE GOVERNMENT OF THE USA, AS REPRESENTED BY THE SECRETARY OF THE ARMY ON BEHALF OF WALTER REED ,  ARMY INSTITUTE OF RESEARCH ,  NEW YORK UNIVERSITY

发明人： Barton F. Haynes ,  Huaxin Liao ,  Jerome Kim ,  Nelson Michael ,  Susan B. Zolla-Pazner

IPC分类号： C07K14/005 ,  C07K16/10

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  C07K14/162 ,  C07K16/1063 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2710/24043 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates, in general, to human immunodeficiency virus (HIV), and in particular to a vaccine for HIV-1 and to methods of making and using same.

摘要翻译： 本发明一般涉及人类免疫缺陷病毒（HIV），特别涉及用于HIV-1的疫苗及其制备和使用方法。