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1.发明授权公开(公告)号：US10987452B2
公开(公告)日：2021-04-27
申请号：US16422999
申请日：2019-05-25
摘要： A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with an amphiphilic polymer coating comprising a therapeutic agent and an amphiphilic polymer or co-polymer. The medical disposable device is inserted into a body lumen, and expanded to contact the amphiphilic polymer coating against the body lumen. The total solubility of the polymer or co-polymer in vivo prevents any embolic hazard associated with the amphiphilic polymer coating.
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2.发明授权公开(公告)号：US10117970B2
公开(公告)日：2018-11-06
申请号：US15471579
申请日：2017-03-28
IPC分类号： A61K31/337 , A61L29/08 , A61L29/14 , A61L29/16 , A61M25/10
摘要： A method and device for local delivery of a water-insoluble therapeutic agent to the tissue of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with a non-durable coating which comprises poly(HEMA) complexed with iodine and has a substantially water-insoluble therapeutic agent dispersed therein. The medical disposable device is inserted into a body lumen, and expanded to contact the non-durable coating against the body lumen and deliver the substantially water-insoluble therapeutic agent to the body lumen tissue.
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3.发明申请公开(公告)号：US20170224875A1
公开(公告)日：2017-08-10
申请号：US15471579
申请日：2017-03-28
IPC分类号： A61L29/08 , A61M25/10 , A61K31/337 , A61L29/16 , A61L29/14
CPC分类号： A61L29/085 , A61K31/337 , A61L29/148 , A61L29/16 , A61L33/0005 , A61L2300/204 , A61L2300/416 , A61L2400/00 , A61L2420/06 , A61M25/10 , A61M25/1027 , A61M2025/105 , A61M2025/1075 , A61M2025/1081 , A61M2025/109 , C08L33/02
摘要： A method and device for local delivery of a water-insoluble therapeutic agent to the tissue of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with a non-durable coating which comprises poly(HEMA) complexed with iodine and has a substantially water-insoluble therapeutic agent dispersed therein. The medical disposable device is inserted into a body lumen, and expanded to contact the non-durable coating against the body lumen and deliver the substantially water-insoluble therapeutic agent to the body lumen tissue.
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4.发明申请LOCAL DELIVERY OF WATER-SOLUBLE OR WATER-INSOLUBLE THERAPEUTIC AGENTS TO THE SURFACE OF BODY LUMENS 审中-公开将水溶性或水不溶性治疗剂局部输送到身体的表面公开(公告)号：US20150224229A1
公开(公告)日：2015-08-13
申请号：US14695114
申请日：2015-04-24
CPC分类号： A61L29/085 , A61K9/0024 , A61L29/141 , A61L29/16 , A61L2300/216 , A61L2420/02 , A61L2420/06 , A61M25/104 , A61M2025/105 , A61M2025/1075
摘要： A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with an amphiphilic polymer coating comprising a therapeutic agent and an amphiphilic polymer or co-polymer. The medical disposable device is inserted into a body lumen, and expanded to contact the amphiphilic polymer coating against the body lumen. The total solubility of the polymer or co-polymer in vivo prevents any embolic hazard associated with the amphiphilic polymer coating.
摘要翻译： 公开了一种将水溶性或水不溶性治疗剂局部递送到正常或患病体腔表面的方法和装置。 医疗一次性装置（例如球囊导管的球囊）的可膨胀结构用包含治疗剂和两亲性聚合物或共聚物的两亲性聚合物涂层涂覆。 将医疗一次性装置插入体腔中，并膨胀以使两亲性聚合物涂层抵靠体腔接触。 聚合物或共聚物在体内的总溶解度可防止与两亲性聚合物涂层相关的任何栓塞危险。
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5.发明授权公开(公告)号：US10314948B2
公开(公告)日：2019-06-11
申请号：US14695114
申请日：2015-04-24
摘要： A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with an amphiphilic polymer coating comprising a therapeutic agent and an amphiphilic polymer or co-polymer. The medical disposable device is inserted into a body lumen, and expanded to contact the amphiphilic polymer coating against the body lumen. The total solubility of the polymer or co-polymer in vivo prevents any embolic hazard associated with the amphiphilic polymer coating.
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6.发明授权公开(公告)号：US10046093B2
公开(公告)日：2018-08-14
申请号：US14935754
申请日：2015-11-09
摘要： A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with an amphiphilic polymer coating comprising a therapeutic agent and an amphiphilic polymer or co-polymer. The medical disposable device is inserted into a body lumen, and expanded to contact the amphiphilic polymer coating against the body lumen. The total solubility of the polymer or co-polymer in vivo prevents any embolic hazard associated with the amphiphilic polymer coating.
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7.发明授权公开(公告)号：US09603973B2
公开(公告)日：2017-03-28
申请号：US14852790
申请日：2015-09-14
CPC分类号： A61L29/085 , A61L29/148 , A61L29/16 , A61L33/0005 , A61L2300/204 , A61L2300/416 , A61L2400/00 , A61L2420/06 , A61M25/10 , A61M25/1027 , A61M2025/105 , A61M2025/1075 , A61M2025/1081 , A61M2025/109 , C08L33/02
摘要： A method and device for local delivery of a water-insoluble therapeutic agent to the tissue of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with a non-durable coating which comprises poly(HEMA) complexed with iodine and has a substantially water-insoluble therapeutic agent dispersed therein. The medical disposable device is inserted into a body lumen, and expanded to contact the non-durable coating against the body lumen and deliver the substantially water-insoluble therapeutic agent to the body lumen tissue.
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8.发明申请公开(公告)号：US20160058916A1
公开(公告)日：2016-03-03
申请号：US14935754
申请日：2015-11-09
CPC分类号： A61L29/106 , A61K47/02 , A61L29/10 , A61L29/16 , A61L2300/114 , A61L2300/216 , A61L2300/41 , A61L2300/416
摘要： A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with an amphiphilic polymer coating comprising a therapeutic agent and an amphiphilic polymer or co-polymer. The medical disposable device is inserted into a body lumen, and expanded to contact the amphiphilic polymer coating against the body lumen. The total solubility of the polymer or co-polymer in vivo prevents any embolic hazard associated with the amphiphilic polymer coating.
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9.发明申请公开(公告)号：US20160000975A1
公开(公告)日：2016-01-07
申请号：US14852790
申请日：2015-09-14
CPC分类号： A61L29/085 , A61L29/148 , A61L29/16 , A61L33/0005 , A61L2300/204 , A61L2300/416 , A61L2400/00 , A61L2420/06 , A61M25/10 , A61M25/1027 , A61M2025/105 , A61M2025/1075 , A61M2025/1081 , A61M2025/109 , C08L33/02
摘要： A method and device for local delivery of a water-insoluble therapeutic agent to the tissue of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with a non-durable coating which comprises poly(HEMA) complexed with iodine and has a substantially water-insoluble therapeutic agent dispersed therein. The medical disposable device is inserted into a body lumen, and expanded to contact the non-durable coating against the body lumen and deliver the substantially water-insoluble therapeutic agent to the body lumen tissue.
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