公开(公告)号：US20190083462A1

公开(公告)日：2019-03-21

申请号：US16085896

申请日：2017-03-17

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM ,  TRUSTEES OF TUFTS COLLEGE

Inventor： Robert C. Alaniz ,  Arul Jayaraman ,  Kyongbum Lee ,  Canaan Whitfield ,  Noah Cohen

IPC: A61K31/405 ,  A61K45/06 ,  A61P1/00

Abstract: This disclosure relates to methods and compositions for addressing conditions of dysbiosis and/or inflammation, such as enteropathy, associated with administration of non-steroidal anti-inflammatory drug (NSAID). The disclosure includes methods comprising administering an effective amount of a tryptophan derived microbiota metabolite (TDMM) to a subject that has also been administered, or is expected to have administered, a NSAID.

公开(公告)号：US20240189279A1

公开(公告)日：2024-06-13

申请号：US18536002

申请日：2023-12-11

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM ,  TRUSTEES OF TUFTS COLLEGE

Inventor： Arul Jayaraman ,  Kyongbum Lee

IPC: A61K31/405 ,  A61K9/00 ,  A61K31/4045 ,  A61P1/16 ,  A61P11/00 ,  A61P31/14

CPC classification number: A61K31/405 ,  A61K9/0053 ,  A61K31/4045 ,  A61P1/16 ,  A61P11/00 ,  A61P31/14

Abstract: Provided here are immunomodulatory compositions for and methods of treatment of inflammation-associated diseases, such as liver disorders and acute respiratory distress syndrome (ARDS). The composition can be a tryptophan metabolite, such as indole 3-acetate, tryptamine, xanthurenic acid, or a derivative of any thereof. The methods can include administering the subject a therapeutically effective amount of the immunomodulatory composition provided herein. The liver disorders can be non-alcoholic fatty liver disease, steatosis, non-alcoholic steatohepatitis, and/or fibrosis. The ARDS can be associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

公开(公告)号：US20200217778A1

公开(公告)日：2020-07-09

申请号：US16607787

申请日：2018-04-30

Applicant: The Texas A&M University System

Inventor： Susmitha Purnima Kotu ,  Arul Jayaraman ,  Mahboobul Sam Mannan ,  Arum Han

IPC: G01N17/02 ,  B01L3/00 ,  C12Q1/02 ,  G01N17/04

Abstract: A method for determining the susceptibility of a material to corrosion includes generating, via an inlet in a monitoring device, a laminar flow of material comprising a plurality of microorganisms. The plurality of microorganisms comprises at least one microorganism type. The method also includes forming, inside the monitoring device, in response to the laminar flow, a biofilm comprising at least one microorganism type. In addition, the method includes applying a voltage to the first and second electrodes during the laminar flow.

公开(公告)号：US11612586B2

公开(公告)日：2023-03-28

申请号：US16085912

申请日：2017-03-17

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM ,  TRUSTEES OF TUFTS COLLEGE

Inventor： Robert C. Alaniz ,  Arul Jayaraman ,  Kyongbum Lee

IPC: A61K31/405 ,  A61K31/404 ,  A61K31/475 ,  A61K35/17 ,  A61K45/06 ,  A61P1/00 ,  A61P29/00 ,  C12N5/0783 ,  C12N5/0784 ,  A61K35/12 ,  A61K31/7004

Abstract: The disclosure provides methods and compositions for affecting the development of antigen presenting cell (APC, e.g., a macrophage or dendritic cell). The methods include maturing an APC, promoting anti-inflammatory phenotype, promoting development of a T regulatory cell (Treg) from a naive T cell. The methods generally include exposing an APC to a tryptophan derived microbiota metabolite (TDMM), such as an anti-inflammatory or pro-mucosal TDMM, and permitting the APC to mature. In some embodiments, the conditioned APC is exposed to a naive T cell to further promote development of a T regulatory cell (Treg). In some embodiments, the TDMM is selected from the group consisting of indole, indole-3-acetate, 5-hydroxyindole, and indole-3-pyruvate.

公开(公告)号：US20190032014A1

公开(公告)日：2019-01-31

申请号：US16085926

申请日：2017-03-17

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM ,  TRUSTEES OF TUFTS COLLEGE

Inventor： Robert C. Alaniz ,  Arul Jayaraman ,  Kyongbum Lee

IPC: C12N5/0783 ,  A61K31/405 ,  A61K35/17 ,  A61K31/475 ,  A61P29/00

Abstract: Disclosed are compositions derived from the commensal microbiota and related methods for inducing and differentiating naive T cells. In some embodiments, the compositions and methods can be selectively used to generate stable regulatory T-cells (Tregs or iTregs) or stabilize such Tregs to prevent inflammatory responses and instead promote antigen tolerance. Alternatively, in other aspects, select compositions can be used to promote pro-inflammatory T cell development, such as through the induced development and stabilization of Th1 and Th7 cells.