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    ORGAN-ON-CHIPS THAT MIMIC HUMAN PREGNANCY AND PARTURITION
    6.
    发明申请
    ORGAN-ON-CHIPS THAT MIMIC HUMAN PREGNANCY AND PARTURITION 有权

    公开(公告)号：US20220002646A1

    公开(公告)日：2022-01-06

    申请号：US17336730

    申请日：2021-06-02

    Applicant: The Texas A&M University System ,  Board of Regents, The University of Texas System

    Inventor： Arum Han ,  Sungjin Kim ,  Ramkumar Menon ,  Lauren Richardson ,  Ourlad Alzeus Tantengco

    IPC: C12M3/00 ,  C12M3/06 ,  C12M1/26 ,  C12M1/12 ,  C12M1/00

    Abstract: In an embodiment, the present disclosure pertains to an organ-chip model having a plurality of cell culture chambers connected through arrays of microfluidic channels. In some embodiments, each cell culture chamber of the plurality of cell culture chambers include an inlet and an outlet. In some embodiments, the inlet is configured to receive at least one of a cell, cell media, or a cell stimulant. In some embodiments, at least one outlet is configured to collect effluent. In some embodiments, the organ-chip model can include, without limitation, an organ-chip model of amnion membrane, an organ-chip model of a feto-maternal interface (fetal membrane-decidua parietalis), an organ-chip model of a feto-maternal interface (placenta-decidua interface), an organ-chip model of a cervix, and combinations thereof. In some embodiments, the organ-chip model is an interconnected organ-chip model having a combination of one or more organ-chip models with interconnected cell culture chambers.

    HIGH-THROUGHPUT MUTAGENIZED CELL SCREENING SYSTEM FOR SELECTIVE SINGLE CELL EXTRACTION
    8.
    发明申请
    HIGH-THROUGHPUT MUTAGENIZED CELL SCREENING SYSTEM FOR SELECTIVE SINGLE CELL EXTRACTION 有权
    用于选择性单细胞提取的高通量MUTAGENIZED细胞筛选系统

    公开(公告)号：US20150291995A1

    公开(公告)日：2015-10-15

    申请号：US14438659

    申请日：2013-10-28

    Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

    Inventor： Arum Han ,  Hyun Soo Kim

    IPC: C12Q1/24 ,  B01L3/00 ,  G01N33/50

    CPC classification number: C12Q1/24 ,  B01L3/502753 ,  B01L2200/0668 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0655 ,  B01L2400/086 ,  C12M47/04 ,  G01N33/5005

    Abstract: The subject invention pertains to a microfluidic apparatus and methods for screening and isolating a target cell from a population of cells. The apparatus comprises a first microfluidic layer comprising microfluidic channels; a second microfluidic layer comprising microfluidic channels; and a microfluidic cell analysis layer comprising a top hanging blocking structure located directly below each location where the first layer microfluidic channels overlap with the second layer microfluidic channels and a cell trap juxtaposed to each of the top hanging blocking structures. The top hanging blocking structures can close or open the juxtaposed cell trap when either or both the first or second layer microfluidic channels located directly above the top hanging blocking structure are sufficiently pressurized and/or sufficiently depressurized. The methods for screening and isolating a target cell from a population of cells comprise screening the population of cells using the apparatus and isolating the target cell interest therefrom.

    Abstract translation: 本发明涉及用于从细胞群中筛选和分离靶细胞的微流体装置和方法。 该装置包括包含微流体通道的第一微流体层; 包含微流体通道的第二微流体层; 以及微流体细胞分析层，其包含位于每个位置正下方的顶部悬挂阻断结构，其中所述第一层微流体通道与所述第二层微流体通道重叠，以及与所述顶部悬挂阻挡结构中的每一个并置的细胞阱。 当位于顶部悬挂阻挡结构正上方的第一或第二层微流体通道中的任一个或二者均被充分加压和/或充分减压时，顶部悬挂的阻挡结构可以闭合或打开并置的细胞阱。 从细胞群筛选和分离靶细胞的方法包括使用该装置筛选细胞群并从其中分离靶细胞的兴趣。

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