公开(公告)号：US20170216275A1

公开(公告)日：2017-08-03

申请号：US15235736

申请日：2016-08-12

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Yan FENG ,  Ottavio ARANCIO ,  Shixian DENG ,  Donald W. LANDRY

IPC分类号： A61K31/4706

CPC分类号： A61K31/4706 ,  C07D215/48 ,  C07D215/54

摘要： The invention provides for compounds that are phosphodiesterase inhibitors. The invention further provides for a method for screening compounds that bind to and modulate a phosphosdiesterase protein. The invention also provides methods for treating conditions associated with accumulated amyloid-beta peptide deposit accumulations by administering a phosphodiesterase-binding compound to a subject.

公开(公告)号：US20210317074A1

公开(公告)日：2021-10-14

申请号：US17317133

申请日：2021-05-11

申请人： The Trustees of Columbia University in the City of New York

发明人： Yan FENG ,  Mauro FA ,  Ottavio ARANCIO ,  Shixian DENG ,  Donald W. LANDRY ,  Yitshak FRANCIS

IPC分类号： C07C235/64 ,  C07C323/67 ,  C07C323/42 ,  C07D213/82 ,  C07D213/75 ,  C07C235/56 ,  C07C237/40 ,  C07D239/52 ,  C07D333/38 ,  A61K49/00 ,  C12Q1/48 ,  C07C323/60 ,  C07C323/44

摘要： The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.

公开(公告)号：US20180244603A1

公开(公告)日：2018-08-30

申请号：US15968524

申请日：2018-05-01

申请人： The Trustees of Columbia University in the City of New York

发明人： Yitshak FRANCIS ,  Mauro FA ,  Ottavio ARANCIO ,  Jole FIORITO ,  Shixian DENG ,  Donald W. LANDRY ,  Michal LUZAC ,  Yan FENG

IPC分类号： C07C217/22 ,  C07D209/48 ,  C07D295/088 ,  C07D265/14

CPC分类号： C07C217/22 ,  C07C217/58 ,  C07C235/60 ,  C07C235/64 ,  C07C251/24 ,  C07D209/48 ,  C07D265/14 ,  C07D265/36 ,  C07D295/088

摘要： The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels and/or accumulations of alpha-synuclein as well as cancer by administering a compound hat modulates HAT to a subject.