公开(公告)号：US20180179248A1

公开(公告)日：2018-06-28

申请号：US15579741

申请日：2016-06-03

Applicant: The Trustees of Princeton University

Inventor： David MACMILLAN ,  Daniel NOVOA ,  Stefan MCCARVER

IPC: C07K1/113 ,  C25B3/10 ,  B01J31/18 ,  B01J35/00

CPC classification number: C07K1/113 ,  B01J31/181 ,  B01J31/1815 ,  B01J35/004 ,  B01J2231/324 ,  B01J2231/348 ,  B01J2531/827 ,  B01J2540/12 ,  B01J2540/22 ,  B01J2540/225 ,  C07K1/107 ,  C07K5/0205 ,  C25B3/10

Abstract: Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside.