公开(公告)号：US20240352486A1

公开(公告)日：2024-10-24

申请号：US18754912

申请日：2024-06-26

申请人： The Trustees of Princeton University

发明人： Cliff BRANGWYNNE ,  Yongdae SHIN ,  Dan BRACHA

IPC分类号： C12N15/90 ,  C07K14/47 ,  C12N9/22

CPC分类号： C12N15/90 ,  C07K14/47 ,  C12N9/22

摘要： Disclosed is a system and method for the controlled clustering of gene regulatory proteins at the specific target genomic loci. The technology enables formation of liquid-like droplets closely interfaced with genome organization. This technology can be utilized for perturbing endogenous nuclear structures as well as nucleating synthetic membrane-less assemblies. The technology can also be utilized for inducing or detecting mechanical stresses within the genome.

公开(公告)号：US20210047659A1

公开(公告)日：2021-02-18

申请号：US16964052

申请日：2019-01-23

申请人： The Trustees of Princeton University

发明人： Cliff BRANGWYNNE ,  Yongdae SHIN ,  Dan BRACHA

IPC分类号： C12N15/90 ,  C12N9/22 ,  C07K14/47

摘要： Disclosed is a system and method for the controlled clustering of gene regulatory proteins at the specific target genomic loci. The technology enables formation of liquid-like droplets closely interfaced with genome organization. This technology can be utilized for perturbing endogenous nuclear structures as well as nucleating synthetic membrane-less assemblies. The technology can also be utilized for inducing or detecting mechanical stresses within the genome.