专利检索 ap:("The Trustees of the University of Pennsylvania" OR "Advaxis, Inc.") AND inv:"Paulo MaCiag" 第 1 页

1.

发明授权
Non-hemolytic LLO fusion proteins and methods of utilizing same 有权

公开(公告)号：US09499602B2

公开(公告)日：2016-11-22

申请号：US14163269

申请日：2014-02-12

申请人： The Trustees of the University of Pennsylvania , Advaxis, Inc.

发明人： Yvonne Paterson , Paulo MaCiag

IPC分类号： C12N1/20 , C12N15/63 , C07K14/705 , A61K39/00 , A61K39/385 , C07K14/195 , C12N9/52 , A61K39/02 , C07K16/00

CPC分类号： C07K14/705 , A61K39/00 , A61K39/0011 , A61K39/0208 , A61K39/385 , A61K2039/53 , A61K2039/55522 , C07K14/195 , C07K16/00 , C07K2317/56 , C07K2319/40 , C12N9/52

摘要： The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest.