公开(公告)号：US09549973B2

公开(公告)日：2017-01-24

申请号：US14581217

申请日：2014-12-23

申请人： The Trustees of the University of Pennsylvania ,  Advaxis, Inc.

发明人： Yvonne Paterson ,  John Rothman ,  Vafa Shahabi

IPC分类号： C07K1/00 ,  A61K39/00 ,  A61K39/02 ,  C12N9/64 ,  C07K14/195

CPC分类号： A61K39/0011 ,  A61K39/02 ,  A61K2039/523 ,  A61K2039/53 ,  C07K14/195 ,  C07K2319/00 ,  C07K2319/40 ,  C12N9/485 ,  C12N9/6445 ,  C12Y304/17021 ,  C12Y304/21077

摘要： The present invention provides KLK3 peptides, FOLH1 peptides, recombinant polypeptides comprising same, recombinant nucleotide molecules encoding same, recombinant Listeria strains comprising same, and immunogenic and therapeutic methods utilizing same.

摘要翻译： 本发明提供KLK3肽，FOLH1肽，包含其的重组多肽，编码其的重组核苷酸分子，包含其的重组利斯特氏菌菌株，以及利用其的免疫原性和治疗方法。

公开(公告)号：US11446369B2

公开(公告)日：2022-09-20

申请号：US16672362

申请日：2019-11-01

申请人： ADVAXIS, INC. ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： Yvonne Paterson ,  John Rothman ,  Vafa Shahabi

IPC分类号： A61K39/02 ,  A61K39/00 ,  C12N9/64 ,  C07K14/195 ,  C12N9/48

摘要： The present invention provides KLK3 peptides, FOLH1 peptides, recombinant polypeptides comprising same, recombinant nucleotide molecules encoding same, recombinant Listeria strains comprising same, and immunogenic and therapeutic methods utilizing same.

公开(公告)号：US20160361401A1

公开(公告)日：2016-12-15

申请号：US15121421

申请日：2015-02-25

申请人： ADVAXIS, INC. ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： Vafa Shahabi ,  Anu Wallecha ,  Paulo C. Maciag ,  Yvonne Paterson ,  Nicola Mason ,  Matthew Seavey

IPC分类号： A61K39/00 ,  C07K14/195 ,  C12N9/90 ,  C12N9/12 ,  C12N1/36 ,  C12N1/20 ,  C07K14/82 ,  C12N15/74

CPC分类号： A61K39/0011 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/572 ,  C07K14/195 ,  C07K14/82 ,  C07K2319/40 ,  C12N1/20 ,  C12N1/36 ,  C12N9/12 ,  C12N9/90 ,  C12N15/74 ,  C12Y207/10 ,  C12Y501/01001

摘要： This invention provides compositions and methods for treating and vaccinating against a HER2/neu antigen-expressing tumor and inducing an immune response against the same in a subject.

摘要翻译： 本发明提供用于治疗和接种针对HER2 / neu抗原表达的肿瘤并在受试者中诱导针对其的免疫应答的组合物和方法。

公开(公告)号：US20150238584A1

公开(公告)日：2015-08-27

申请号：US14189008

申请日：2014-02-25

申请人： Advaxis, Inc. ,  The Trustees of the University of Pennsylvania

发明人： VAFA SHAHABI ,  Anu Wallecha ,  Paulo C. Maciag ,  Yvonne Paterson ,  Nicola Mason ,  Matthew M. Seavey

IPC分类号： A61K39/00

CPC分类号： A61K39/0011 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/572 ,  C07K14/195 ,  C07K14/82 ,  C07K2319/40 ,  C12N1/20 ,  C12N1/36 ,  C12N9/12 ,  C12N9/90 ,  C12N15/74 ,  C12Y207/10 ,  C12Y501/01001

摘要： This invention provides compositions and methods for treating and vaccinating against a Her2/neu antigen-expressing tumor and inducing an immune response against dominant in a non-human animal.

公开(公告)号：US20180265879A1

公开(公告)日：2018-09-20

申请号：US15760263

申请日：2016-09-13

申请人： Advaxis, Inc. ,  The Trustees of the University of Pennsylvania

发明人： Anu Wallecha ,  Yvonne Paterson

IPC分类号： C12N15/74 ,  C12P21/00 ,  C07K14/195 ,  C07K14/025 ,  C07K19/00 ,  A61K39/12

CPC分类号： C12N15/74 ,  A61K35/74 ,  A61K39/0011 ,  A61K39/12 ,  A61K2039/585 ,  A61K2039/6068 ,  A61K2039/6075 ,  A61K2039/892 ,  A61P35/00 ,  C07K14/005 ,  C07K14/025 ,  C07K14/195 ,  C07K19/00 ,  C07K2319/06 ,  C07K2319/55 ,  C12N1/20 ,  C12N5/00 ,  C12N2330/50 ,  C12N2511/00 ,  C12N2710/20022 ,  C12N2710/20033 ,  C12N2710/20034 ,  C12N2710/20043 ,  C12N2710/20051 ,  C12N2740/16234 ,  C12N2800/101 ,  C12P21/00

摘要： The present invention discloses a process for manufacturing a formulation comprising a drug substance, said drug substance comprising a recombinant Listeria comprising a human papilloma virus (HPV) antigen fused to a Listeriolysin O (LLO) protein fragment. The invention further discloses methods of using treating, protecting against, and inducing an immune response against cervical cancer comprising administration of the recombinant Listeria strain. The present invention also provides methods for inducing an anti-E7 CTL response in a human subject and treating HPV-mediated diseases, disorders, and symptoms, comprising administration of the recombinant Listeria strain.

公开(公告)号：US10064898B2

公开(公告)日：2018-09-04

申请号：US15220641

申请日：2016-07-27

申请人： ADVAXIS, INC. ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

发明人： John Rothman ,  Anu Wallecha ,  Reshma Singh ,  Donald A. Harn, Jr. ,  Yvonne Paterson

IPC分类号： A01N63/00 ,  A61K35/74 ,  A61K39/02 ,  A61K39/00 ,  A61K39/12 ,  A61K39/39 ,  A61K45/06 ,  C12N7/00

摘要： This invention provides methods and compositions for using Listeria monocytogenes as an adjuvant for enhancing immune responses in a subject.

公开(公告)号：US09499602B2

公开(公告)日：2016-11-22

申请号：US14163269

申请日：2014-02-12

申请人： The Trustees of the University of Pennsylvania ,  Advaxis, Inc.

发明人： Yvonne Paterson ,  Paulo MaCiag

IPC分类号： C12N1/20 ,  C12N15/63 ,  C07K14/705 ,  A61K39/00 ,  A61K39/385 ,  C07K14/195 ,  C12N9/52 ,  A61K39/02 ,  C07K16/00

CPC分类号： C07K14/705 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/0208 ,  A61K39/385 ,  A61K2039/53 ,  A61K2039/55522 ,  C07K14/195 ,  C07K16/00 ,  C07K2317/56 ,  C07K2319/40 ,  C12N9/52

摘要： The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest.

公开(公告)号：US20150366955A9

公开(公告)日：2015-12-24

申请号：US14189008

申请日：2014-02-25

申请人： Advaxis, Inc. ,  The Trustees of the University of Pennsylvania

发明人： VAFA SHAHABI ,  Anu Wallecha ,  Paulo C. Maciag ,  Yvonne Paterson ,  Nicola Mason ,  Matthew M. Seavey

IPC分类号： A61K39/00

CPC分类号： A61K39/0011 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/572 ,  C07K14/195 ,  C07K14/82 ,  C07K2319/40 ,  C12N1/20 ,  C12N1/36 ,  C12N9/12 ,  C12N9/90 ,  C12N15/74 ,  C12Y207/10 ,  C12Y501/01001

摘要： This invention provides compositions and methods for treating and vaccinating against a Her2/neu antigen-expressing tumor and inducing an immune response against dominant in a non-human animal.

摘要翻译： 本发明提供用于治疗和接种针对Her2 / neu抗原表达的肿瘤并在非人动物中诱导针对显性的免疫应答的组合物和方法。

公开(公告)号：US10189885B2

公开(公告)日：2019-01-29

申请号：US14789226

申请日：2015-07-01

申请人： The Trustees of the University of Pennsylvania ,  Advaxis, Inc.

发明人： Yvonne Paterson ,  Paulo Maciag

IPC分类号： C12N9/52 ,  A61K39/00 ,  A61K39/02 ,  C07K16/00 ,  A61K39/385 ,  C07K14/195 ,  C07K14/705

摘要： The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest.

公开(公告)号：US20170049867A1

公开(公告)日：2017-02-23

申请号：US15225205

申请日：2016-08-01

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： Matthew SEAVEY ,  Yvonne Paterson ,  Paulo Maciag ,  Duane Sewell

IPC分类号： A61K39/00

CPC分类号： A61K39/0011 ,  A61K45/06 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/53 ,  A61K2039/57 ,  A61K2039/585 ,  A61K2039/6037 ,  A61K2039/6068 ,  C07K14/195 ,  C07K14/4748 ,  C07K14/71 ,  C07K2319/55 ,  C12N15/74

摘要： The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.

摘要翻译： 本发明提供了包含血管生成因子的重组利斯特氏菌菌株，其包含与包含PEST样序列的多肽有效连接的血管生成因子，编码该重组核酸分子的重组多肽，相关疫苗以及利用其的免疫原性和治疗方法。