公开(公告)号：US11981707B2

公开(公告)日：2024-05-14

申请号：US18464786

申请日：2023-09-11

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Peter D. Kwong ,  Barney S. Graham ,  Jason S. McLellan ,  Jeffrey Boyington ,  Lei Chen ,  Man Chen ,  Gwo-Yu Chuang ,  Ivelin Stefanov Georgiev ,  Jason Gorman ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Gilad Ofek ,  Marie Pancera ,  Mallika Sastry ,  Cinque Soto ,  Sanjay Srivatsan ,  Guillaume Stewart-Jones ,  Yongping Yang ,  Baoshan Zhang ,  Tongqing Zhou

IPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  C12N7/00 ,  G01N33/564 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  C12N7/00 ,  G01N33/564 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/53 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55561 ,  A61K2039/55566 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/50 ,  C07K2319/70 ,  C07K2319/735 ,  C12N2710/10343 ,  C12N2760/18522 ,  C12N2760/18534

摘要： Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.

公开(公告)号：US20180319846A1

公开(公告)日：2018-11-08

申请号：US16025858

申请日：2018-07-02

申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services

发明人： Peter D. Kwong ,  Barney S. Graham ,  Jason S. McLellan ,  Jeffrey Boyington ,  Lei Chen ,  Man Chen ,  Gwo-Yu Chuang ,  Ivelin Stefanov Georgiev ,  Jason Gorman ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Gilad Ofek ,  Marie Pancera ,  Mallika Sastry ,  Cinque Soto ,  Sanjay Srivatsan ,  Guillaume Stewart-Jones ,  Yongping Yang ,  Baoshan Zhang ,  Tongqing Zhou

IPC分类号： C07K14/005 ,  A61K39/155 ,  C12N7/00 ,  A61K39/12 ,  G01N33/564 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/53 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55561 ,  A61K2039/55566 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/50 ,  C07K2319/70 ,  C07K2319/735 ,  C12N7/00 ,  C12N2710/10343 ,  C12N2760/18522 ,  C12N2760/18534 ,  G01N33/564

摘要： Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.

公开(公告)号：US11130785B2

公开(公告)日：2021-09-28

申请号：US16025858

申请日：2018-07-02

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Peter D. Kwong ,  Barney S. Graham ,  Jason S. McLellan ,  Jeffrey Boyington ,  Lei Chen ,  Man Chen ,  Gwo-Yu Chuang ,  Ivelin Stefanov Georgiev ,  Jason Gorman ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Gilad Ofek ,  Marie Pancera ,  Mallika Sastry ,  Cinque Soto ,  Sanjay Srivatsan ,  Guillaume Stewart-Jones ,  Yongping Yang ,  Baoshan Zhang ,  Tongqing Zhou

IPC分类号： A61K39/155 ,  C07K14/005 ,  A61K39/12 ,  C12N7/00 ,  G01N33/564 ,  A61K39/00

摘要： Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.