专利检索 ap:("The United States of America, as represented by the Secretary, Department of Health AND Human Services") AND inv:"Syed M. Moin" 第 1 页

1.

发明授权
Stabilized group 2 influenza hemagglutinin stem region trimers and uses thereof 有权

公开(公告)号：US11793871B2

公开(公告)日：2023-10-24

申请号：US17742201

申请日：2022-05-11

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Jeffrey C. Boyington , Barney S. Graham , John R. Mascola , Hadi M. Yassine , Kizzmekia S. Corbett , Syed M. Moin , Lingshu Wang , Masaru Kanekiyo

IPC分类号： A61K39/145 , C07K14/005 , C07K14/195 , A61K39/12 , A61P31/16 , A61K39/00

CPC分类号： A61K39/145 , A61K39/12 , A61P31/16 , C07K14/005 , C07K14/195 , A61K2039/55555 , C07K2319/00 , C12N2760/16122 , C12N2760/16134

摘要： Vaccines that elicit broadly protective anti-influenza antibodies. The vaccines comprise nanoparticles that display HA trimers from Group 2 influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to stabilized stem regions of Group 2 influenza virus HA proteins. The fusion proteins self-assemble to form the HA-displaying nanoparticles. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.