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公开(公告)号：US20200030435A1
公开(公告)日：2020-01-30
申请号：US16596175
申请日：2019-10-08
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services , The Government of the United States, as Represented by The Secretary of The Army
发明人： Alexander G. Pletnev , Joseph R. Putnak , Robert M. Chanock , Brian R. Murphy , Stephen S. Whitehead , Joseph E. Blaney
IPC分类号： A61K39/12 , C07K14/005 , C12N7/00 , C12N15/86 , C12Q1/6888
摘要： The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines.
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公开(公告)号：US20180369358A1
公开(公告)日：2018-12-27
申请号：US16025624
申请日：2018-07-02
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services , The Government of the United States, as Represented by The Secretary of the Army
发明人： Alexander G. Pletnev , Joseph R. Putnak , Robert M. Chanock , Brian R. Murphy , Stephen S. Whitehead , Joseph E. Blaney
IPC分类号： A61K39/12 , C12Q1/6888 , C12N7/00 , C07K14/005 , C12N15/86 , A61K39/00
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2770/24122 , C12N2770/24134 , C12N2770/24143 , C12N2770/24162 , C12Q1/6888 , Y02A50/386 , Y02A50/394
摘要： The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines.
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公开(公告)号：US10456461B2
公开(公告)日：2019-10-29
申请号：US16025624
申请日：2018-07-02
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services , The Government of the United States, as Represented by The Secretary of The Army
发明人： Alexander G. Pletnev , Joseph R. Putnak , Robert M. Chanock , Brian R. Murphy , Stephen S. Whitehead , Joseph E. Blaney
IPC分类号： A61K39/12 , C12Q1/6888 , C07K14/005 , C12N7/00 , C12N15/86 , A61K39/00
摘要： The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines.
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公开(公告)号：US20210069317A1
公开(公告)日：2021-03-11
申请号：US16952864
申请日：2020-11-19
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services , The Government of the United States, as Represented by The Secretary of The Army
发明人： Alexander G. Pletnev , Joseph R. Putnak , Robert M. Chanock , Brian R. Murphy , Stephen S. Whitehead , Joseph E. Blaney
IPC分类号： A61K39/12 , C07K14/005 , C12N7/00 , C12N15/86 , C12Q1/6888
摘要： The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines,
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公开(公告)号：US20200147202A1
公开(公告)日：2020-05-14
申请号：US16750437
申请日：2020-01-23
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
IPC分类号： A61K39/12 , C12N7/00 , C12Q1/70 , C07K14/005
摘要： The invention relates to vaccine compositions including CEV serogroup immunogens, attenuated and inactivated viruses of the CEV serogroup and chimeric Bunyaviridae. Also disclosed are methods of treating or preventing CEV serogroup infection in a mammalian host, methods of producing a subunit vaccine composition or an immunogenic composition, isolated polynucleotides comprising a nucleotide sequence encoding a CEV serogroup immunogen, methods for detecting La Crosse virus (LACV) infection in a biological sample and infectious chimeric Bunyaviridae.
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6.发明申请公开(公告)号：US20180008693A1
公开(公告)日：2018-01-11
申请号：US15650482
申请日：2017-07-14
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
IPC分类号： A61K39/12 , C12Q1/70 , C12N7/00 , A61K39/295 , A61K39/00
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/54 , A61K2039/575 , A61K2039/70 , C12N7/00 , C12N2770/24121 , C12N2770/24134 , C12N2770/24161 , C12N2770/24162 , C12N2770/24171 , C12Q1/701 , C12Q2600/156 , G01N2333/18 , G01N2500/10 , Y02A50/386
摘要： A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.
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公开(公告)号：US10206995B2
公开(公告)日：2019-02-19
申请号：US15850696
申请日：2017-12-21
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
IPC分类号： A61K39/12 , C12Q1/70 , C07K14/005 , C12N7/00 , A61K39/00
摘要： The invention relates to vaccine compositions including CEV serogroup immunogens, attenuated and inactivated viruses of the CEV serogroup and chimeric Bunyaviridae. Also disclosed are methods of treating or preventing CEV serogroup infection in a mammalian host, methods of producing a subunit vaccine composition or an immunogenic composition, isolated polynucleotides comprising a nucleotide sequence encoding a CEV serogroup immunogen, methods for detecting La Crosse virus (LACV) infection in a biological sample and infectious chimeric Bunyaviridae.
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公开(公告)号：US10561724B2
公开(公告)日：2020-02-18
申请号：US16240222
申请日：2019-01-04
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
IPC分类号： A61K39/12 , C12Q1/70 , C07K14/005 , C12N7/00 , A61K39/00
摘要： The invention relates to vaccine compositions including CEV serogroup immunogens, attenuated and inactivated viruses of the CEV serogroup and chimeric Bunyaviridae. Also disclosed are methods of treating or preventing CEV serogroup infection in a mammalian host, methods of producing a subunit vaccine composition or an immunogenic composition, isolated polynucleotides comprising a nucleotide sequence encoding a CEV serogroup immunogen, methods for detecting La Crosse virus (LACV) infection in a biological sample and infectious chimeric Bunyaviridae.
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公开(公告)号：US20180104326A1
公开(公告)日：2018-04-19
申请号：US15850696
申请日：2017-12-21
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
IPC分类号： A61K39/12 , C12Q1/70 , C07K14/005
CPC分类号： A61K39/12 , A61K39/00 , A61K2039/5252 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N2760/12022 , C12N2760/12034 , C12Q1/701
摘要： The invention relates to vaccine compositions including CEV serogroup immunogens, attenuated and inactivated viruses of the CEV serogroup and chimeric Bunyaviridae. Also disclosed are methods of treating or preventing CEV serogroup infection in a mammalian host, methods of producing a subunit vaccine composition or an immunogenic composition, isolated polynucleotides comprising a nucleotide sequence encoding a CEV serogroup immunogen, methods for detecting La Crosse virus (LACV) infection in a biological sample and infectious chimeric Bunyaviridae.
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公开(公告)号：US11753627B2
公开(公告)日：2023-09-12
申请号：US17009448
申请日：2020-09-01
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
发明人： Stephen S. Whitehead , Brian R. Murphy , Lewis Markoff , Barry Falgout , Joseph Blaney , Kathryn Hanley , Ching-Juh Lai
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/70 , C12N2770/24134 , C12N2770/24161 , Y02A50/30
摘要： The invention relates to a dengue virus tetravalent vaccine containing a common 30 nucleotide deletion (Δ30) in the 3′-untranslated region of the genome of dengue virus serotypes 1, 2, 3, and 4, or antigenic chimeric dengue viruses of serotypes 1, 2, 3, and 4.
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