公开(公告)号：US20030137069A1

公开(公告)日：2003-07-24

申请号：US10054627

申请日：2002-01-22

申请人： The University of Akron

发明人： Darrell H. Reneker

IPC分类号： C01B031/02 ,  D01D005/088 ,  D01F006/18 ,  D01F009/145 ,  D01F009/22 ,  D04H003/02

CPC分类号： D04H1/70 ,  D01D5/0985 ,  D01F9/12 ,  D01F9/145 ,  D01F9/22 ,  D04H1/4382 ,  D04H3/02

摘要： An apparatus for forming a non-woven mat of nanofibers by using a pressurized gas stream comprises a first member having a supply end defined by one side across the width of said first member and an opposing exit end defined by one side across the width of said first member; a second member having a supply end defined by one side across the width of said second member and an opposing exit end defined by one side across the width of said second member, the second member being located apart from and adjacent to said first member, the length of said second member extending along the length of said first member, said exit end of said second member extending beyond said exit end of said first member, wherein said first and second members define a first supply slit; and a third member having a supply end defined by one side across the width of said third member and an opposing exit end defined by one side across the width of said third member, said third member being located apart from and adjacent to said first member on the opposite side of said first member from said second member, the length of said third member extending along the length of the first member, wherein said first and third members define a first gas slit, and wherein said exit ends of said first, second and third members define a gas jet space. A method for forming a non-woven mat of nanofibers by using a pressurized gas stream is also disclosed.

摘要翻译： 一种通过使用加压气流形成纳米纤维无纺毡的装置包括：第一构件，其具有由穿过所述第一构件的宽度的一侧限定的供给端，以及由所述第一构件的宽度的一侧限定的相对的出口端 第一名成员 第二构件具有由横跨所述第二构件的宽度的一侧限定的供给端和由横跨所述第二构件的宽度的一侧限定的相对的出口端，所述第二构件位于与所述第一构件分开并且与所述第一构件相邻， 所述第二构件的长度沿着所述第一构件的长度延伸，所述第二构件的所述出口端延伸超过所述第一构件的所述出口端，其中所述第一和第二构件限定第一供应狭缝; 以及第三构件，其具有横跨所述第三构件的宽度的一侧限定的供给端和由所述第三构件的宽度的一侧限定的相对的出口端，所述第三构件位于与所述第一构件隔开并与所述第一构件相邻的位置上 所述第一构件与所述第二构件的相对侧，所述第三构件的长度沿着所述第一构件的长度延伸，其中所述第一和第三构件限定第一气体狭缝，并且其中所述第一和第二构件的所述出口端 第三个成员定义了一个气体喷射空间。 还公开了一种通过使用加压气流形成纳米纤维无纺垫的方法。

公开(公告)号：US20040131753A1

公开(公告)日：2004-07-08

申请号：US10738582

申请日：2003-12-16

申请人： The University of Akron

发明人： Daniel J. Smith ,  Darrell H. Reneker

IPC分类号： A61L002/00

CPC分类号： D01F6/96 ,  A61L15/26 ,  A61L15/44 ,  A61L17/145 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/606 ,  A61L2300/624 ,  Y10S623/926 ,  Y10S977/89 ,  Y10T428/2998 ,  C08L79/02

摘要： A novel coating for medical devices provides nitric oxide delivery using nanofibers of linear poly(ethylenimine)diazeniumdiolate. Linear poly(ethylenimine)diazeniumdiolate releases nitric oxide (NO) in a controlled manner to tissues and organs to aid the healing process and to prevent injury to tissues at risk of injury. Electrospun nano-fibers of linear poly(ethylenimine) diazeniumdiolate deliver therapeutic levels of NO to the tissues surrounding a medical device while minimizing the alteration of the properties of the device. A nanofiber coating, because of the small size and large surface area per unit mass of the nanofibers, provides a much larger surface area per unit mass while minimizing changes in other properties of the device.

摘要翻译： 用于医疗装置的新型涂层使用线性聚（亚乙基亚胺）二氮烯鎓二醇的纳米纤维提供一氧化氮递送。 线性聚（亚乙基亚胺）二氮烯鎓二硫酸盐以受控的方式将一氧化氮（NO）释放到组织和器官中，以帮助愈合过程并防止损伤组织的损伤。 线性聚（亚乙基亚胺）二氮烯鎓二醇的电纺纳米纤维向医疗装置周围的组织递送治疗水平的NO，同时最小化装置的性质的改变。 由于纳米纤维的每单位质量的小尺寸和大的表面积，纳米纤维涂层提供了更大的每单位质量的表面积，同时使装置的其它性质的变化最小化。