公开(公告)号：US20130164264A1

公开(公告)日：2013-06-27

申请号：US13712045

申请日：2012-12-12

Applicant: The University of Warwick

Inventor： Nigel Dimmock

IPC: A61K35/76

CPC classification number: A61K39/145 ,  A61K35/76 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/542 ,  A61K2039/543 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16134

Abstract: Cloned, i.e. defined, defective interfering (DI) influenza A virus is produced in embryonated hens eggs using a method which generates large quantities of DI virus material. Co-administration of cloned DI influenza A virus with a lethal dose of virulent influenza A virus conferred protection in mice compared to a control of inactivated cloned DI influenza A virus. Control mice which received only cloned DI influenza A virus and no lethal challenge of virulent influenza A virus were not protected three weeks later on lethal challenge with infective virus. Cloned DI influenza A virus of one subtype is found to act in vivo as an effective antiviral against the same or any other sub-type of influenza A virus. The antiviral effect has been found to have both a therapeutic and a prophylactic application against influenza A infection in humans, mammals and birds.

Abstract translation: 克隆，即定义的，有缺陷的干扰（DI）甲型流感病毒是使用产生大量DI病毒材料的方法在胚胎母鸡卵中产生的。 与对照灭活的克隆的D型甲型流感病毒相比，克隆的DI甲型流感病毒与致死剂量的毒性流感A病毒的共同给药在小鼠中赋予了保护作用。 只有克隆的D型甲型流感病毒对照小鼠，并且没有致命的甲型流感病毒感染攻击，在感染性病毒的致死性攻击三周后没有得到保护。 发现一种亚型的克隆的甲型流感病毒A型病毒在体内作为针对相同或任何其它亚型甲型流感病毒的有效抗病毒药物起作用。 已经发现抗病毒作用具有针对人，哺乳动物和鸟类中甲型流感感染的治疗和预防性应用。

公开(公告)号：US09089516B2

公开(公告)日：2015-07-28

申请号：US13712045

申请日：2012-12-12

Applicant: The University of Warwick

Inventor： Nigel Dimmock

IPC: A61K35/12 ,  A61K39/145 ,  A61K35/76 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K39/145 ,  A61K35/76 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/542 ,  A61K2039/543 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16134

Abstract: Cloned, i.e. defined, defective interfering (DI) influenza A virus is produced in embryonated hens eggs using a method which generates large quantities of DI virus material. Co-administration of cloned DI influenza A virus with a lethal dose of virulent influenza A virus conferred protection in mice compared to a control of inactivated cloned DI influenza A virus. Control mice which received only cloned DI influenza A virus and no lethal challenge of virulent influenza A virus were not protected three weeks later on lethal challenge with infective virus. Cloned DI influenza A virus of one subtype is found to act in vivo as an effective antiviral against the same or any other sub-type of influenza A virus. The antiviral effect has been found to have both a therapeutic and a prophylactic application against influenza A infection in humans, mammals and birds.

Abstract translation: 克隆，即定义的，有缺陷的干扰（DI）甲型流感病毒是使用产生大量DI病毒材料的方法在胚胎母鸡卵中产生的。 与对照灭活的克隆的D型甲型流感病毒相比，克隆的DI甲型流感病毒与致死剂量的毒性流感A病毒的共同给药在小鼠中赋予了保护作用。 只有克隆的D型甲型流感病毒对照小鼠，并且没有致命的甲型流感病毒感染攻击，在感染性病毒的致死性攻击三周后没有得到保护。 发现一种亚型的克隆的甲型流感病毒A型病毒在体内作为针对相同或任何其它亚型甲型流感病毒的有效抗病毒药物起作用。 已经发现抗病毒作用具有针对人，哺乳动物和鸟类中甲型流感感染的治疗和预防性应用。