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1.发明授权Derivatives of pentacyclo undecanes, processes for preparing these compounds, and pharmaceutical compositions thereof 失效五十烷十一烷的衍生物，制备这些化合物的方法及其药物组合物
公开(公告)号：US4622430A
公开(公告)日：1986-11-11
申请号：US452028
申请日：1982-12-21
IPC分类号： C07C17/093 , A61K31/015 , A61K31/025 , A61K31/13 , A61P25/00 , A61P31/12 , C07C1/00 , C07C13/64 , C07C17/00 , C07C23/46 , C07C27/00 , C07C29/143 , C07C31/137 , C07C35/44 , C07C67/00 , C07C209/00 , C07C209/40 , C07C209/50 , C07C209/52 , C07C209/62 , C07C211/38 , C07C211/40 , C07C211/41 , C07C213/00 , C07C215/08 , C07C101/48
CPC分类号： C07C211/41 , C07C2103/91
摘要： Pentacyclo[6.3.0.0..sup.2,6.0.sup.3,10.0.sup.5,9 ]undecane and its derivatives are prepared. The compounds find use as antiviral agents.
摘要翻译： 制备五环[6.3.0.0.2,6.03,10.05,9]十一烷及其衍生物。 该化合物可用作抗病毒剂。
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2.发明授权
公开(公告)号：US4503256A
公开(公告)日：1985-03-05
申请号：US390415
申请日：1982-06-21
IPC分类号： C07C69/017 , A01N35/04 , A01N37/10 , A01N43/12 , A01N43/16 , A01N49/00 , A61K31/12 , A61K31/34 , A61K31/343 , A61P31/04 , C07C45/00 , C07C45/46 , C07C45/68 , C07C45/71 , C07C49/82 , C07C49/825 , C07C49/83 , C07C49/835 , C07C49/84 , C07C67/00 , C07D307/79 , C07D311/58 , C07D311/70 , C07C49/78
CPC分类号： C07D307/79 , A01N35/04 , A01N37/10 , A01N43/12 , A01N43/16 , A01N49/00 , A61K31/12 , C07C45/46 , C07C45/68 , C07C45/71 , C07C49/825 , C07C49/83 , C07C49/835 , C07C49/84 , C07D311/70
摘要： Novel compounds of general formula I ##STR1## wherein R is a branched or unbranched alkyl, cycloalkyl, or aralkyl group, which group optionally contains or is substituted by a halogen or oxygen function, the oxygen function optionally being in the form of an alcohol or ether moiety;R.sub.1, R.sub.2, and R.sub.3, which may be the same or different, is hydrogen, an alkyl, acyl, or benzoyl group, which group optionally contains or is substituted by a halogen or oxygen function;R.sub.4 is hydrogen, an alkyl, alkenyl preferably being an allyl or prenyl group, or aralkyl group which group optionally contains or is substituted by an alkyl, aryl, halogen or oxygen function;R.sub.5 is hydrogen, an alkyl, aralkyl, acyl, or aryl group, which group optionally contains or is substituted by an alkyl, aryl, halogen, or oxygen function;except that R.sub.4 and R.sub.5 are not both hydrogen;and except for the compounds when R.sub.5 is hydrogen and R is methyl, i-propyl, branched butyl, methoxy methyl, 2-phenylethyl, or 2-phenylethylene;chromans and dihydrobenzofurans derived from these compounds;pharmaceutically acceptable salts, and metabolites and metabolic precursors of these compounds;processes for preparing the aforementioned types of compounds;use of the aforementioned types of compounds as antibacterial and/or antimycotic agents;and pharmaceutical compositions of such compounds.
摘要翻译： 通式I的新型化合物其中R为支链或非支链烷基，环烷基或芳烷基，该基团任选地含有或被卤素或氧官能团取代，氧官能团任选呈醇形式 或醚部分; R 1，R 2和R 3可以相同或不同，为氢，烷基，酰基或苯甲酰基，该基团任选地含有或被卤素或氧官能团取代; R4是氢，烷基，烯基优选是烯丙基或异戊烯基，或芳烷基，任选地含有或被烷基，芳基，卤素或氧官能团取代; R5是氢，烷基，芳烷基，酰基或芳基，该基团任选地含有或被烷基，芳基，卤素或氧官能团取代; 不同之处在于R4和R5不同时为氢; 除了R 5为氢，R为甲基，异丙基，支链丁基，甲氧基甲基，2-苯基乙基或2-苯基乙烯的化合物为例。 衍生自这些化合物的苯并二氢吡喃酮和二氢苯并呋喃; 药学上可接受的盐，这些化合物的代谢物和代谢前体; 制备上述类型化合物的方法; 使用上述类型的化合物作为抗细菌剂和/或抗真菌剂; 和这些化合物的药物组合物。
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3.发明授权
公开(公告)号：US4578520A
公开(公告)日：1986-03-25
申请号：US679272
申请日：1984-12-07
IPC分类号： C07C69/017 , A01N35/04 , A01N37/10 , A01N43/12 , A01N43/16 , A01N49/00 , A61K31/12 , A61K31/34 , A61K31/343 , A61P31/04 , C07C45/00 , C07C45/46 , C07C45/68 , C07C45/71 , C07C49/82 , C07C49/825 , C07C49/83 , C07C49/835 , C07C49/84 , C07C67/00 , C07D307/79 , C07D311/58 , C07D311/70
CPC分类号： C07D307/79 , A01N35/04 , A01N37/10 , A01N43/12 , A01N43/16 , A01N49/00 , A61K31/12 , C07C45/46 , C07C45/68 , C07C45/71 , C07C49/825 , C07C49/83 , C07C49/835 , C07C49/84 , C07D311/70
摘要： Novel compounds of general formula I ##STR1## wherein R is a branched or unbranched alkyl, cycloalkyl, or aralkyl group, which group optionally contains or is substituted by a halogen or oxygen function, the oxygen function optionally being in the form of an alcohol or ether moiety;R.sub.1, R.sub.2, and R.sub.3, which may be the same or different, is hydrogen, an alkyl, acyl, or benzoyl group, which group optionally contains or is substituted by a halogen or oxygen function;R.sub.4 is hydrogen, an alkyl, alkenyl preferably being an allyl or prenyl group, or aralkyl group which group optionally contains or is substituted by an alkyl, aryl, halogen or oxygen function;R.sub.5 is hydrogen, an alkyl, aralkyl, acyl, or aryl group, which group optionally contains or is substituted by an alkyl, aryl, halogen, or oxygen function; except that R.sub.4 and R.sub.5 are not both hydrogen;and except for the compounds when R.sub.5 is hydrogen and R is methyl, i-propyl, branched butyl, methoxy methyl, 2-phenylethyl, or 2-phenylethylene;chromans and dihydrobenzofurans derived from these compounds;pharmaceutically acceptable salts, and metabolites and metabolic precursors of these compounds;processes for preparing the aforementioned types of compounds; use of the aforementioned types of compounds as antibacterial and/or antimycotic agents;and pharmaceutical compositions of such compounds.
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公开(公告)号：US4752606A
公开(公告)日：1988-06-21
申请号：US650574
申请日：1984-09-14
IPC分类号： A61K31/19 , A61K31/195 , A61K31/215 , A61K31/60 , A61P1/04 , A61P25/04 , A61P29/00 , C07C62/32 , A61K31/61
CPC分类号： A61K31/19 , C07C62/32 , Y10S514/974
摘要： The invention provides oleanolic acid and/or a physiologically acceptable salt thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced and/or stress-induced.The invention also provides a pharmaceutical composition comprising an active amount of oleanolic acid and/or a physiologically acceptable salt thereof in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of oleanolic acid in preventing and/or significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
摘要翻译： 本发明提供齐墩果酸和/或其生理上可接受的盐，用于预防和/或治疗患者胃和/或肠的溃疡型障碍物。 溃疡性疾病可以是化学诱导和/或应激诱导的类型。 本发明还提供一种药物组合物，其包含与止痛化合物和/或抗炎化合物组合的活性量的齐墩果酸和/或其生理学上可接受的盐。 本发明进一步提供齐墩果酸用于预防和/或显着减少和/或治疗治疗胃和/或肠的溃疡形成型病症。
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公开(公告)号：US5137908A
公开(公告)日：1992-08-11
申请号：US628512
申请日：1990-12-13
IPC分类号： C07D487/08
CPC分类号： C07D487/08
摘要： 4-Azahexacyclo (5.4.1.0.sup.2,6 .0.sup.3,10 .0.sup.5,9 .0.sup.8,11) dodecane compounds of the formula ##STR1## wherein R, A and B each is hydrogen; a linear or branched alkyl group having one to twelve carbon atoms and optionally including a hydroxyl or halogen substituent; or a phenyl group alone or optionally substituted with a linear or branched alkyl group having one to twelve carbons, which group optionally includes a hydroxyl or halogen substituent; and X is a hydroxyl or --NR.sub.2 group where R is as stated above; or an acid addition salt of such compound. These compounds are useful in pharmaceutical compositions wherein the compound is included in an amount effective to be used as a calcium antogonist, a cardiac agent or an anti-hypertensive agent.
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