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公开(公告)号:US07511065B2
公开(公告)日:2009-03-31
申请号:US10535061
申请日:2003-11-12
申请人: Theodore Goodson, Jr. , Mary Margaret Mader , John Eldon Toth , Arindam Chatterjee , Jason Scott Sawyer
发明人: Theodore Goodson, Jr. , Mary Margaret Mader , John Eldon Toth , Arindam Chatterjee , Jason Scott Sawyer
IPC分类号: C07D487/04
CPC分类号: C07D487/04
摘要: The present invention provides a compound of the formula: (Formula I); or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.
摘要翻译: 本发明提供下式的化合物:(式I); 其药物组合物包含有效量的式I化合物与合适的载体,稀释剂或赋形剂的组合,以及用于治疗生理障碍,特别是充血性心脏病的方法,包括向其中的患者施用 有效量的式I化合物。
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公开(公告)号:US20080113977A1
公开(公告)日:2008-05-15
申请号:US10535061
申请日:2003-11-12
IPC分类号: A61K31/541 , A61K31/5377 , A61K31/4709 , C07D487/02
CPC分类号: C07D487/04
摘要: The present invention provides a compound of the formula: (Formula I); or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.
摘要翻译: 本发明提供下式的化合物:(式I); 其药物组合物包含有效量的式I化合物与合适的载体,稀释剂或赋形剂的组合,以及用于治疗生理障碍,特别是充血性心脏病的方法,包括向其中的患者施用 有效量的式I化合物。
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公开(公告)号:US08440829B2
公开(公告)日:2013-05-14
申请号:US13347886
申请日:2012-01-11
IPC分类号: C07D471/04
CPC分类号: A61K31/4745 , C07D471/04
摘要: The present invention provides an imidazo[4,5-c]quinolin-2-one compound, or a pharmaceutically acceptable salt thereof, that inhibits both PI3K and mTOR and, therefore, is useful in the treatment of cancer.
摘要翻译: 本发明提供抑制PI3K和mTOR两者的咪唑并[4,5-c]喹啉-2-酮化合物或其药学上可接受的盐,因此可用于治疗癌症。
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公开(公告)号:US20120184577A1
公开(公告)日:2012-07-19
申请号:US13347886
申请日:2012-01-11
IPC分类号: A61K31/4745 , A61P35/00 , C07D471/04
CPC分类号: A61K31/4745 , C07D471/04
摘要: The present invention provides an imidazo[4,5-c]quinolin-2-one compound, or a pharmaceutically acceptable salt thereof, that inhibits both PI3K and mTOR and, therefore, is useful in the treatment of cancer.
摘要翻译: 本发明提供抑制PI3K和mTOR两者的咪唑并[4,5-c]喹啉-2-酮化合物或其药学上可接受的盐,因此可用于治疗癌症。
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公开(公告)号:US20080275056A1
公开(公告)日:2008-11-06
申请号:US12089420
申请日:2006-10-23
申请人: Alfonso De Dios , Cristina Garcia-Paredes , Beatriz Lopez Uralde Garmendia , Mary Margaret Mader , Mark Andrew Pobanz , Chuan Shih , Boyu Zhong
发明人: Alfonso De Dios , Cristina Garcia-Paredes , Beatriz Lopez Uralde Garmendia , Mary Margaret Mader , Mark Andrew Pobanz , Chuan Shih , Boyu Zhong
IPC分类号: A61K31/496 , C07D401/14 , A61K31/4725
CPC分类号: C07D403/12 , C07D403/14
摘要: The present invention provides kinase inhibitors of Formula (I) wherein R1, R2, and X are as described herein, or a pharmaceutically acceptable salt thereof.
摘要翻译: 本发明提供其中R1,R2和X如本文所述的式(I)的激酶抑制剂或其药学上可接受的盐。
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公开(公告)号:US07084170B2
公开(公告)日:2006-08-01
申请号:US10490935
申请日:2002-10-15
申请人: Cora Sue Grossman , Philip Arthur Hipskind , Ho-Shen Lin , Karen Lynn Lobb , Beatriz Lopez de Uralde Garmendia , Jose Eduardo Lopez , Mary Margaret Mader , Michael Enrico Richett , Chuan Shih , Alfonso De Dios
发明人: Cora Sue Grossman , Philip Arthur Hipskind , Ho-Shen Lin , Karen Lynn Lobb , Beatriz Lopez de Uralde Garmendia , Jose Eduardo Lopez , Mary Margaret Mader , Michael Enrico Richett , Chuan Shih , Alfonso De Dios
IPC分类号: A61K31/381 , C07D333/34
CPC分类号: C07D277/36 , C07D333/34 , C07D333/38
摘要: The present invention provides antineoplastic compounds of the formula: and antineoplastic methods.
摘要翻译: 本发明提供下式的抗肿瘤化合物和抗肿瘤方法。
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公开(公告)号:US20090118323A1
公开(公告)日:2009-05-07
申请号:US11853158
申请日:2007-09-11
IPC分类号: A61K31/4365 , C07D307/78 , A61K31/343 , C07D317/46 , A61K31/335 , C07C311/15 , A61K31/426 , C07D209/04 , A61P35/00 , A61K31/404 , C07D319/16 , C07D277/62 , A61K31/18 , C07D333/52 , A61K31/381 , C07D471/02
CPC分类号: C07D307/79 , C07C311/51 , C07C2602/06 , C07C2602/08 , C07D209/08 , C07D209/30 , C07D277/64 , C07D317/44 , C07D317/62 , C07D319/18 , C07D333/54 , C07D495/04
摘要: The present invention provides antitumor compounds of the formula (I); and antitumor methods.
摘要翻译: 本发明提供式(I)的抗肿瘤化合物; 和抗肿瘤的方法。
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公开(公告)号:US07282595B2
公开(公告)日:2007-10-16
申请号:US10535002
申请日:2003-11-13
IPC分类号: C07D333/62
CPC分类号: C07D307/79 , C07C311/51 , C07C2602/06 , C07C2602/08 , C07D209/08 , C07D209/30 , C07D277/64 , C07D317/44 , C07D317/62 , C07D319/18 , C07D333/54 , C07D495/04
摘要: The present invention provides antitumor compounds of the formula (I); and antitumor methods.
摘要翻译: 本发明提供式(I)的抗肿瘤化合物; 和抗肿瘤方法。
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公开(公告)号:US07250430B2
公开(公告)日:2007-07-31
申请号:US11447457
申请日:2006-06-06
申请人: Cora Sue Grossman , Philip Arthur Hipskind , Ho-Shen Lin , Karen Lynn Lobb , Beatriz Lopez de Uralde Garmendia , Jose Eduardo Lopez , Mary Margaret Mader , Michael Enrico Richett , Chuan Shih , Alfonso De Dios
发明人: Cora Sue Grossman , Philip Arthur Hipskind , Ho-Shen Lin , Karen Lynn Lobb , Beatriz Lopez de Uralde Garmendia , Jose Eduardo Lopez , Mary Margaret Mader , Michael Enrico Richett , Chuan Shih , Alfonso De Dios
IPC分类号: A61K31/381 , A61K31/426
CPC分类号: C07D277/36 , C07D333/34 , C07D333/38
摘要: The present invention provides antineoplastic compounds of the formula: and antineoplastic methods.
摘要翻译: 本发明提供下式的抗肿瘤化合物和抗肿瘤方法。
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公开(公告)号:US07652015B2
公开(公告)日:2010-01-26
申请号:US12088526
申请日:2006-10-25
申请人: Jolie Anne Bastian , Jesus Andres Blas de Blas , Alfonso De Dios , Kevin John Hudziak , Tiechao Li , Beatriz López De Uralde-Garmendia , Mary Margaret Mader , Michael Ray Myers , Mark Andrew Pobanz , Chuan Shih , Boyu Zhong
发明人: Jolie Anne Bastian , Jesus Andres Blas de Blas , Alfonso De Dios , Kevin John Hudziak , Tiechao Li , Beatriz López De Uralde-Garmendia , Mary Margaret Mader , Michael Ray Myers , Mark Andrew Pobanz , Chuan Shih , Boyu Zhong
IPC分类号: A61K31/4439 , A61K31/454 , C07D401/12 , C07D401/14 , C07D409/14
CPC分类号: C07D401/12 , C07D401/14
摘要: The present invention provides kinase inhibitors of Formula (I). Wherein R1, R2, X and Z are as described herein, or a pharmaceutically acceptable salt thereof.
摘要翻译: 本发明提供式(I)的激酶抑制剂。 其中R1,R2,X和Z如本文所述,或其药学上可接受的盐。
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