公开(公告)号：US20210280407A1

公开(公告)日：2021-09-09

申请号：US16808244

申请日：2020-03-03

Applicant: Thermo Finnigan LLC

Inventor： Harald Oser ,  Raman Mathur

IPC: H01J49/06 ,  H01J49/42

Abstract: A first multipole assembly includes a first plurality of rod electrodes arranged about an axis and configured to confine ions radially about the axis. A second multipole assembly disposed adjacent to the first multipole assembly includes a second plurality of rod electrodes arranged about the axis and configured to confine the ions radially about the axis. An orientation of the first multipole assembly about the axis is rotationally offset relative to an orientation of the second multipole assembly about the axis.

公开(公告)号：US09583321B2

公开(公告)日：2017-02-28

申请号：US14138589

申请日：2013-12-23

Applicant: Thermo Finnigan LLC

Inventor： Oleg Silivra ,  Harald Oser ,  Terry N. Olney

IPC: H01J49/26 ,  H01J49/00

CPC classification number: H01J49/0031 ,  H01J49/0036 ,  H01J49/004

Abstract: A mass spectrometry method comprises: introducing a first portion of a sample of ions including precursor ions comprising a first precursor-ion mass-to-charge (m/z) ratio into a first mass analyzer; transmitting the precursor ions from the first mass analyzer to a reaction or fragmentation cell such that a first population of product ions are continuously accumulated therein over a first accumulation time duration; initiating release of the accumulated first population of product ions from the reaction or fragmentation cell; continuously transmitting the released first population of product ions from the reaction cell to a second mass analyzer; transmitting a portion of the released first population of product ions comprising a first product-ion m/z ratio from the second mass analyzer to a detector; and detecting a varying quantity of the product ions having the first product-ion m/z ratio for a predetermined data-acquisition time period after the initiation of the release.

Abstract translation: 一种质谱法包括：将包含第一前体 - 离子质量 - 电荷（m / z）比率的前体离子的离子样品的第一部分引入第一质量分析器; 将所述前体离子从所述第一质量分析器传输到反应或破碎单元，使得第一种产物离子在第一累积持续时间内连续地累积在其中; 开始从反应或碎裂细胞释放累积的第一批产物离子; 将释放的第一批产物离子从反应池连续传输到第二质量分析器; 将包含第一产物离子m / z比率的所述释放的第一产物离子群的一部分从所述第二质量分析器传输到检测器; 以及在释放开始之后，在预定的数据采集时间段内检测具有第一乘积离子m / z比的产物离子的变化量。

公开(公告)号：US11756780B2

公开(公告)日：2023-09-12

申请号：US17541086

申请日：2021-12-02

Applicant: Thermo Finnigan LLC

Inventor： Harald Oser ,  Raman Mathur

IPC: H01J49/06 ,  H01J49/42

CPC classification number: H01J49/063 ,  H01J49/065 ,  H01J49/4225

Abstract: A first multipole assembly includes a first plurality of rod electrodes arranged about an axis and configured to confine ions radially about the axis. A second multipole assembly disposed adjacent to the first multipole assembly includes a second plurality of rod electrodes arranged about the axis and configured to confine the ions radially about the axis. An orientation of the first multipole assembly about the axis is rotationally offset relative to an orientation of the second multipole assembly about the axis.

公开(公告)号：US09842730B2

公开(公告)日：2017-12-12

申请号：US14963123

申请日：2015-12-08

Applicant: Thermo Finnigan LLC

Inventor： Alan E. Schoen ,  Harald Oser

IPC: H01J49/00 ,  H01J49/42

CPC classification number: H01J49/005 ,  H01J49/0031 ,  H01J49/421

Abstract: A method for operating a mass spectrometer so as to detect or quantify analytes, comprises: (a) identifying a selected-reaction-monitoring (SRM) transition to be used for each respective analyte; (b) determining a time duration required for a fragmentation reaction corresponding to each identified transition to proceed to a threshold percentage of completion; and (c) for each analyte, performing the steps of (i) isolating ions corresponding to a precursor-ion mass-to-charge (m/z) ratio of the respective transition; (ii) fragmenting the respective isolated ions in one of two fragmentation cells or fragmentation cell portions; and (ii) mass analyzing for fragment ions corresponding to a product-ion m/z ratio of the respective transition, wherein, for each analyte, the fragmentation cell or fragmentation cell portion that is used for fragmenting the isolated ions is determined from the time duration determined for the respective analyte.

公开(公告)号：US09508534B2

公开(公告)日：2016-11-29

申请号：US14535937

申请日：2014-11-07

Applicant: Thermo Finnigan LLC

Inventor： Oleg Silivra ,  Harald Oser ,  Joshua T. Maze

IPC: H01J49/26 ,  H01J49/00 ,  H01J49/02 ,  H01J43/04

CPC classification number: H01J49/0009 ,  H01J43/04 ,  H01J49/025

Abstract: Method for operating a mass spectrometer includes supplying a quantity of ions to an ion detector. The ion detector can include a conversion dynode operating in a first polarity and an electron multiplier. The method further includes adjusting the gain of the electron multiplier to determine a first set of calibration parameters, and calculating a second set of calibration parameters for the electron multiplier from the first set of calibration parameters. The second set of calibration parameters are for a second polarity of the conversion dynode. The method can further include configuring the ion detector to operate at the second polarity based on the second set of calibration parameters, and supplying ions of the second polarity to the mass spectrometer, and detecting an ion at a particular mass to charge ratio using the ion detector.

Abstract translation: 用于操作质谱仪的方法包括向离子检测器提供一定量的离子。 离子检测器可以包括以第一极性操作的转换倍增电极和电子倍增器。 该方法还包括调整电子倍增器的增益以确定第一组校准参数，以及从第一组校准参数计算电子倍增器的第二组校准参数。 第二组校准参数用于转换倍增电极的第二极性。 该方法还可以包括将离子检测器配置为基于第二组校准参数以第二极性操作，并将第二极性的离子提供给质谱仪，并使用离子检测特定质荷比的离子 探测器。

公开(公告)号：US20220230862A1

公开(公告)日：2022-07-21

申请号：US17541086

申请日：2021-12-02

Applicant: Thermo Finnigan LLC

Inventor： Harald Oser ,  Raman Mathur

IPC: H01J49/06 ,  H01J49/42

Abstract: A first multipole assembly includes a first plurality of rod electrodes arranged about an axis and configured to confine ions radially about the axis. A second multipole assembly disposed adjacent to the first multipole assembly includes a second plurality of rod electrodes arranged about the axis and configured to confine the ions radially about the axis. An orientation of the first multipole assembly about the axis is rotationally offset relative to an orientation of the second multipole assembly about the axis.

公开(公告)号：US10607824B2

公开(公告)日：2020-03-31

申请号：US16181280

申请日：2018-11-05

Applicant: Thermo Finnigan LLC

Inventor： Bennett S. Kalafut ,  Harald Oser

IPC: H01J49/00 ,  H01J49/42

Abstract: A mass spectrometer includes a collision cell and a system controller. The collision cell includes a plurality of rod pairs configured to generate pseudopotential well through the application of radio frequency potentials to the rod pairs. The collision cell configured to generate a target fragment from a parent ion by colliding the parent ion with one or more gas molecules. The system controller is configured to set a radio frequency amplitude of the radio frequency potentials to a default amplitude; monitor the production of a target fragment ion while adjusting the collision energy; set the collision energy to optimize the production of the target fragment ion; apply a linear full range ramp to the radio frequency amplitude to determine an optimal radio frequency amplitude; and set the radio frequency amplitude to the optimal radio frequency amplitude for the parent ion, target fragment ion pair.

公开(公告)号：US11201044B2

公开(公告)日：2021-12-14

申请号：US16808244

申请日：2020-03-03

Applicant: Thermo Finnigan LLC

Inventor： Harald Oser ,  Raman Mathur

IPC: H01J49/06 ,  H01J49/42

Abstract: A first multipole assembly includes a first plurality of rod electrodes arranged about an axis and configured to confine ions radially about the axis. A second multipole assembly disposed adjacent to the first multipole assembly includes a second plurality of rod electrodes arranged about the axis and configured to confine the ions radially about the axis. An orientation of the first multipole assembly about the axis is rotationally offset relative to an orientation of the second multipole assembly about the axis.

公开(公告)号：US10950422B2

公开(公告)日：2021-03-16

申请号：US16831685

申请日：2020-03-26

Applicant: Thermo Finnigan LLC

Inventor： Bennett S. Kalafut ,  Harald Oser

IPC: H01J49/00 ,  H01J49/42

Abstract: A mass spectrometer includes a collision cell and a system controller. The collision cell includes a plurality of rod pairs configured to generate pseudopotential well through the application of radio frequency potentials to the rod pairs. The collision cell configured to generate a target fragment from a parent ion by colliding the parent ion with one or more gas molecules. The system controller is configured to set a radio frequency amplitude of the radio frequency potentials to a default amplitude; monitor the production of a target fragment ion while adjusting the collision energy; set the collision energy to optimize the production of the target fragment ion; apply a linear full range ramp to the radio frequency amplitude to determine an optimal radio frequency amplitude; and set the radio frequency amplitude to the optimal radio frequency amplitude for the parent ion, target fragment ion pair.

公开(公告)号：US10128094B2

公开(公告)日：2018-11-13

申请号：US15446756

申请日：2017-03-01

Applicant: Thermo Finnigan LLC

Inventor： Bennett S. Kalafut ,  Harald Oser

IPC: H01J49/26 ,  H01J49/00 ,  H01J49/42

Abstract: A mass spectrometer includes a collision cell and a system controller. The collision cell includes a plurality of rod pairs configured to generate pseudopotential well through the application of radio frequency potentials to the rod pairs. The collision cell configured to generate a target fragment from a parent ion by colliding the parent ion with one or more gas molecules. The system controller is configured to set a radio frequency amplitude of the radio frequency potentials to a default amplitude; monitor the production of a target fragment ion while adjusting the collision energy; set the collision energy to optimize the production of the target fragment ion; apply a linear full range ramp to the radio frequency amplitude to determine an optimal radio frequency amplitude; and set the radio frequency amplitude to the optimal radio frequency amplitude for the parent ion, target fragment ion pair.