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1.发明授权Method for detecting complexes containing human leukocyte antigen A2 (HLA-A2) molecules and a tyrosinase drived peptide on abnormal cells 失效在异常细胞上检测含有人白细胞抗原A2（HLA-A2）分子和酪氨酸酶驱动肽的复合物的方法
公开(公告)号：US5487974A
公开(公告)日：1996-01-30
申请号：US81673
申请日：1993-06-23
申请人： Thierry Boon-Falleur , Vincent Brichard , Aline Van Pel , Etienne De Plaen , Pierre Coulie , Jean-Christope Renauld , Thomas Wolfel , Bernard Lethe
发明人： Thierry Boon-Falleur , Vincent Brichard , Aline Van Pel , Etienne De Plaen , Pierre Coulie , Jean-Christope Renauld , Thomas Wolfel , Bernard Lethe
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K39/00 , A61K48/00 , A61K49/00 , A61P43/00 , C07K7/06 , C07K14/47 , C12N5/06 , C12N5/10 , C12N9/02 , C12Q1/02 , G01N33/50 , G01N33/569 , G01N33/574 , C12Q1/68
CPC分类号： G01N33/56972 , C07K14/4748 , C12N9/0071 , C12Y114/18001 , G01N33/505 , G01N33/5743 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention relates to the identification of complexes of human leukocyte antigen A2 (HLA-A2) molecules and a tyrosinase-derived peptide having the amino acid sequence Met Leu Leu Ala Val Leu Tyr Cys Leu Leu. The invention further relates to the detection of these complexes on the surface of abnormal cells and, in particular, on the surface of melanoma cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
摘要翻译： 本发明涉及鉴定人白细胞抗原A2（HLA-A2）分子和具有氨基酸序列Met Leu Leu Ala Val Leu Tyr Cys Leu Leu的酪氨酸酶衍生肽的复合物。 本发明还涉及这些复合物在异常细胞表面的检测，特别是在黑素瘤细胞的表面上的检测。 该观察的治疗和诊断结果是本发明的主题。
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2.发明授权METHOD FOR IDENTIFYING INDIVIDUALS SUFFERING FROM A CELLULAR ABNORMALITY SOME OF WHOSE ABNORMAL CELLS PRESENT COMPLEXES OF HUMAN LEUKOCYTE ANTIGEN TYROSINASE DERIVED PEPTIDES, AND METHODS FOR TREATING SAID INDIVIDUALS 有权用于鉴定个体异常的方法从细胞异常中产生一些异常细胞产生人类白细胞抗原类型转移酶衍生肽的复合物，以及用于治疗上述个体的方法公开(公告)号：US06669946B2
公开(公告)日：2003-12-30
申请号：US10011436
申请日：2001-12-11
申请人： Thierry Boon-Falleur , Vincent Brichard , Aline Van Pel , Etienne De Plaen , Pierre Coulie , Jean-Christope Renauld , Thomas Wölfel , Bernard Lethe
发明人： Thierry Boon-Falleur , Vincent Brichard , Aline Van Pel , Etienne De Plaen , Pierre Coulie , Jean-Christope Renauld , Thomas Wölfel , Bernard Lethe
IPC分类号： A61K3900
CPC分类号： G01N33/56972 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4748 , C07K14/535 , C07K16/243 , C12N9/0071 , C12Y114/18001 , G01N33/505 , Y10S436/813 , Y10S514/885 , Y10S530/828
摘要： The invention relates to complexes of human leukocyte antigen molecules and tyrosinase derived peptides SEQ ID NO: 2, on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
摘要翻译： 本发明涉及异常细胞表面上的人白细胞抗原分子和酪氨酸酶衍生肽SEQ ID NO：2的复合物。 该观察的治疗和诊断结果是本发明的主题。
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公开(公告)号：US5843688A
公开(公告)日：1998-12-01
申请号：US583238
申请日：1996-01-05
申请人： Thomas Wolfel , Aline Van Pel , Vincent Brichard , Thierry Boon-Falleur , Etienne DePlaen , Pierre Coulie , Jean-Christophe Renauld , Bernard Lethe
发明人： Thomas Wolfel , Aline Van Pel , Vincent Brichard , Thierry Boon-Falleur , Etienne DePlaen , Pierre Coulie , Jean-Christophe Renauld , Bernard Lethe
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K39/00 , A61K48/00 , A61K49/00 , A61P43/00 , C07K7/06 , C07K14/47 , C12N5/06 , C12N5/10 , C12N9/02 , C12Q1/02 , G01N33/50 , G01N33/569 , G01N33/53 , A61K38/04 , A61K39/385
CPC分类号： G01N33/56972 , C07K14/4748 , C12N9/0071 , C12Y114/18001 , G01N33/505 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
摘要翻译： 本发明涉及在异常细胞表面鉴定人白细胞抗原分子和酪氨酸酶衍生肽的复合物。 该观察的治疗和诊断结果是本发明的主题。
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公开(公告)号：US5530096A
公开(公告)日：1996-06-25
申请号：US203054
申请日：1994-02-28
申请人： Thomas Wolfel , Aline Van Pel , Vincent Brichard , Thierry Boon-Falleur , Etienne DePlaen , Pierre Coulie , Jean-Christophe Renauld , Bernard Lethe
发明人： Thomas Wolfel , Aline Van Pel , Vincent Brichard , Thierry Boon-Falleur , Etienne DePlaen , Pierre Coulie , Jean-Christophe Renauld , Bernard Lethe
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K39/00 , A61K48/00 , A61K49/00 , A61P43/00 , C07K7/06 , C07K14/47 , C12N5/06 , C12N5/10 , C12N9/02 , C12Q1/02 , G01N33/50 , G01N33/569 , A61K38/08
CPC分类号： G01N33/56972 , C07K14/4748 , C12N9/0071 , C12Y114/18001 , G01N33/505 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
摘要翻译： 本发明涉及在异常细胞表面鉴定人白细胞抗原分子和酪氨酸酶衍生肽的复合物。 该观察的治疗和诊断结果是本发明的主题。
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公开(公告)号：US5744316A
公开(公告)日：1998-04-28
申请号：US587391
申请日：1996-01-17
IPC分类号： C12N15/09 , A61K31/00 , A61K35/14 , A61K35/76 , A61K38/00 , A61K38/46 , A61K39/00 , A61K45/00 , A61K48/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P43/00 , C07K7/06 , C07K14/47 , C07K14/74 , C12N9/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/569 , A61K38/04 , A61K39/385
CPC分类号： C12Y114/18001 , C07K14/4748 , C07K14/70539 , C12N9/0071 , G01N33/505 , G01N33/5091 , G01N33/56972 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
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公开(公告)号：US20090274716A1
公开(公告)日：2009-11-05
申请号：US12502274
申请日：2009-07-14
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/154
摘要： The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LAGE-1 gene product.
摘要翻译： 本发明描述了LAGE-1肿瘤相关基因，包括片段，等位变体和剪接变体。 还包括由这些基因编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以LAGE-1基因产物表达为特征的病症的方法和产品。
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公开(公告)号：US07998483B2
公开(公告)日：2011-08-16
申请号：US12502274
申请日：2009-07-14
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/154
摘要： The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LAGE-1 gene product.
摘要翻译： 本发明描述了LAGE-1肿瘤相关基因，包括片段，等位变体和剪接变体。 还包括由这些基因编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以LAGE-1基因产物表达为特征的病症的方法和产品。
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8.发明授权Method for determining head and neck squamous cell carcinomas, prostate carcinomas, and bladder tumors by assaying for mage-3 失效通过测定法师-3确定头颈鳞状细胞癌，前列腺癌和膀胱肿瘤的方法
公开(公告)号：US5512437A
公开(公告)日：1996-04-30
申请号：US204727
申请日：1994-03-01
申请人： Beatrice Gaugler , Thierry Boon-Falleur , Benoit van den Eynde , Etienne DePlaen , Francis Basseur , Bernard Lethe , Pierre van der Bruggen
发明人： Beatrice Gaugler , Thierry Boon-Falleur , Benoit van den Eynde , Etienne DePlaen , Francis Basseur , Bernard Lethe , Pierre van der Bruggen
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/158
摘要： A method for determining head and neck squamous cell carcinomas, bladder tumors and prostate carcinomas is described. The method involves assaying for expression of the gene coding for tumor rejection antigen precursor MAGE-3, or its expression product. Various assays, and kits useful for these assays, are described.
摘要翻译： 描述了确定头颈鳞状细胞癌，膀胱肿瘤和前列腺癌的方法。 该方法包括测定编码肿瘤排斥抗原前体MAGE-3或其表达产物的基因的表达。 描述了可用于这些测定的各种测定和试剂盒。
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9.发明授权Method for determining lung adenocarcinomas by assaying for one or more of MAGE-1, MAGE-2 and MAGE-3 失效通过测定MAGE-1，MAGE-2和MAGE-3中的一种或多种来测定肺腺癌的方法
公开(公告)号：US5763165A
公开(公告)日：1998-06-09
申请号：US209172
申请日：1994-03-10
申请人： Thierry Boon-Falleur , Patrick Weynants , Bernard Lethe , Francis Brasseur , Marie Marchand , Charles DeSmet , Christophe Lurquin , Pierre van der Bruggen , Etienne DePlaen
发明人： Thierry Boon-Falleur , Patrick Weynants , Bernard Lethe , Francis Brasseur , Marie Marchand , Charles DeSmet , Christophe Lurquin , Pierre van der Bruggen , Etienne DePlaen
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/158
摘要： A method for determining lung adenocarcinomas is described. The method involves assaying for expression of a gene coding for at least one of tumor rejection antigen precursors MAGE-1, 2 and 3, or their expression product.
摘要翻译： 描述了确定肺腺癌的方法。 该方法包括测定编码肿瘤排斥抗原前体MAGE-1,2和3中的至少一种或其表达产物的基因的表达。
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公开(公告)号：US06794131B1
公开(公告)日：2004-09-21
申请号：US09341829
申请日：1999-10-18
IPC分类号： C12Q168
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/154
摘要： The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LAGE-1 gene product.
摘要翻译： 本发明描述了LAGE-1肿瘤相关基因，包括片段，等位变体和剪接变体。 还包括由这些基因编码的多肽及其片段，与之相关的抗体。 还提供了用于诊断和治疗以LAGE-1基因产物表达为特征的病症的方法和产品。
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