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公开(公告)号：US5843688A
公开(公告)日：1998-12-01
申请号：US583238
申请日：1996-01-05
申请人： Thomas Wolfel , Aline Van Pel , Vincent Brichard , Thierry Boon-Falleur , Etienne DePlaen , Pierre Coulie , Jean-Christophe Renauld , Bernard Lethe
发明人： Thomas Wolfel , Aline Van Pel , Vincent Brichard , Thierry Boon-Falleur , Etienne DePlaen , Pierre Coulie , Jean-Christophe Renauld , Bernard Lethe
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K39/00 , A61K48/00 , A61K49/00 , A61P43/00 , C07K7/06 , C07K14/47 , C12N5/06 , C12N5/10 , C12N9/02 , C12Q1/02 , G01N33/50 , G01N33/569 , G01N33/53 , A61K38/04 , A61K39/385
CPC分类号： G01N33/56972 , C07K14/4748 , C12N9/0071 , C12Y114/18001 , G01N33/505 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
摘要翻译： 本发明涉及在异常细胞表面鉴定人白细胞抗原分子和酪氨酸酶衍生肽的复合物。 该观察的治疗和诊断结果是本发明的主题。
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公开(公告)号：US5744316A
公开(公告)日：1998-04-28
申请号：US587391
申请日：1996-01-17
IPC分类号： C12N15/09 , A61K31/00 , A61K35/14 , A61K35/76 , A61K38/00 , A61K38/46 , A61K39/00 , A61K45/00 , A61K48/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P43/00 , C07K7/06 , C07K14/47 , C07K14/74 , C12N9/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/569 , A61K38/04 , A61K39/385
CPC分类号： C12Y114/18001 , C07K14/4748 , C07K14/70539 , C12N9/0071 , G01N33/505 , G01N33/5091 , G01N33/56972 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
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3.发明授权Method for detecting complexes containing human leukocyte antigen A2 (HLA-A2) molecules and a tyrosinase drived peptide on abnormal cells 失效在异常细胞上检测含有人白细胞抗原A2（HLA-A2）分子和酪氨酸酶驱动肽的复合物的方法
公开(公告)号：US5487974A
公开(公告)日：1996-01-30
申请号：US81673
申请日：1993-06-23
申请人： Thierry Boon-Falleur , Vincent Brichard , Aline Van Pel , Etienne De Plaen , Pierre Coulie , Jean-Christope Renauld , Thomas Wolfel , Bernard Lethe
发明人： Thierry Boon-Falleur , Vincent Brichard , Aline Van Pel , Etienne De Plaen , Pierre Coulie , Jean-Christope Renauld , Thomas Wolfel , Bernard Lethe
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K39/00 , A61K48/00 , A61K49/00 , A61P43/00 , C07K7/06 , C07K14/47 , C12N5/06 , C12N5/10 , C12N9/02 , C12Q1/02 , G01N33/50 , G01N33/569 , G01N33/574 , C12Q1/68
CPC分类号： G01N33/56972 , C07K14/4748 , C12N9/0071 , C12Y114/18001 , G01N33/505 , G01N33/5743 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention relates to the identification of complexes of human leukocyte antigen A2 (HLA-A2) molecules and a tyrosinase-derived peptide having the amino acid sequence Met Leu Leu Ala Val Leu Tyr Cys Leu Leu. The invention further relates to the detection of these complexes on the surface of abnormal cells and, in particular, on the surface of melanoma cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
摘要翻译： 本发明涉及鉴定人白细胞抗原A2（HLA-A2）分子和具有氨基酸序列Met Leu Leu Ala Val Leu Tyr Cys Leu Leu的酪氨酸酶衍生肽的复合物。 本发明还涉及这些复合物在异常细胞表面的检测，特别是在黑素瘤细胞的表面上的检测。 该观察的治疗和诊断结果是本发明的主题。
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公开(公告)号：US5530096A
公开(公告)日：1996-06-25
申请号：US203054
申请日：1994-02-28
申请人： Thomas Wolfel , Aline Van Pel , Vincent Brichard , Thierry Boon-Falleur , Etienne DePlaen , Pierre Coulie , Jean-Christophe Renauld , Bernard Lethe
发明人： Thomas Wolfel , Aline Van Pel , Vincent Brichard , Thierry Boon-Falleur , Etienne DePlaen , Pierre Coulie , Jean-Christophe Renauld , Bernard Lethe
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K39/00 , A61K48/00 , A61K49/00 , A61P43/00 , C07K7/06 , C07K14/47 , C12N5/06 , C12N5/10 , C12N9/02 , C12Q1/02 , G01N33/50 , G01N33/569 , A61K38/08
CPC分类号： G01N33/56972 , C07K14/4748 , C12N9/0071 , C12Y114/18001 , G01N33/505 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
摘要翻译： 本发明涉及在异常细胞表面鉴定人白细胞抗原分子和酪氨酸酶衍生肽的复合物。 该观察的治疗和诊断结果是本发明的主题。
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5.发明授权METHOD FOR IDENTIFYING INDIVIDUALS SUFFERING FROM A CELLULAR ABNORMALITY SOME OF WHOSE ABNORMAL CELLS PRESENT COMPLEXES OF HUMAN LEUKOCYTE ANTIGEN TYROSINASE DERIVED PEPTIDES, AND METHODS FOR TREATING SAID INDIVIDUALS 有权用于鉴定个体异常的方法从细胞异常中产生一些异常细胞产生人类白细胞抗原类型转移酶衍生肽的复合物，以及用于治疗上述个体的方法公开(公告)号：US06669946B2
公开(公告)日：2003-12-30
申请号：US10011436
申请日：2001-12-11
申请人： Thierry Boon-Falleur , Vincent Brichard , Aline Van Pel , Etienne De Plaen , Pierre Coulie , Jean-Christope Renauld , Thomas Wölfel , Bernard Lethe
发明人： Thierry Boon-Falleur , Vincent Brichard , Aline Van Pel , Etienne De Plaen , Pierre Coulie , Jean-Christope Renauld , Thomas Wölfel , Bernard Lethe
IPC分类号： A61K3900
CPC分类号： G01N33/56972 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4748 , C07K14/535 , C07K16/243 , C12N9/0071 , C12Y114/18001 , G01N33/505 , Y10S436/813 , Y10S514/885 , Y10S530/828
摘要： The invention relates to complexes of human leukocyte antigen molecules and tyrosinase derived peptides SEQ ID NO: 2, on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
摘要翻译： 本发明涉及异常细胞表面上的人白细胞抗原分子和酪氨酸酶衍生肽SEQ ID NO：2的复合物。 该观察的治疗和诊断结果是本发明的主题。
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6.发明授权Tumor rejection antigen precursor processed to at least one tumor rejection antigen presented by HLA-A2 失效被HLA-A2提供的至少一种肿瘤排斥抗原加工成肿瘤排斥抗原前体
公开(公告)号：US5854203A
公开(公告)日：1998-12-29
申请号：US398409
申请日：1995-03-03
申请人： Vincent Brichard , Aline Van Pel , Catia Traversari , Thomas Wolfel , Thierry Boon-Falleur , Etienne De Plaen
发明人： Vincent Brichard , Aline Van Pel , Catia Traversari , Thomas Wolfel , Thierry Boon-Falleur , Etienne De Plaen
IPC分类号： A61K38/00 , C07H21/04 , C07K14/47 , C12N5/10 , C12N15/09 , C12P21/02 , G01N33/574 , A01N37/18 , C07H21/02 , C07K1/00
CPC分类号： C07K14/4748 , G01N33/57484 , A61K38/00
摘要： The invention relates to nucleic acid molecules coding for a tumor rejection antigen precursor. Specifically, the tumor rejection antigen precursor, or "TRAP", is processed into at least one tumor rejection antigen, which is presented by HLA-A2 molecules. Ramifications of the discovery are also set forth.
摘要翻译： 本发明涉及编码肿瘤排斥抗原前体的核酸分子。 具体地，将肿瘤排斥抗原前体或“TRAP”加工成由HLA-A2分子呈递的至少一种肿瘤排斥抗原。 还发现了这一发现的发现。
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7.发明授权Method for identifying individuals suffering from a cellular abnormality some of whose abnormal cells present complexes of HLA-A2/tyrosinase derived peptides, and methods for treating said individuals 失效用于鉴定患有细胞异常的个体的方法，其一些异常细胞呈现HLA-A2 /酪氨酸酶衍生肽的复合物，以及用于治疗所述个体的方法
公开(公告)号：US5747271A
公开(公告)日：1998-05-05
申请号：US636676
申请日：1996-04-23
申请人： Thierry Boon-Falleur , Vincent Brichard , Aline Van Pel , Etienne De Plaen , Pierre Coulie , Jean-Christope Renauld , Thomas Wolfel
发明人： Thierry Boon-Falleur , Vincent Brichard , Aline Van Pel , Etienne De Plaen , Pierre Coulie , Jean-Christope Renauld , Thomas Wolfel
IPC分类号： A61K39/00 , C07K14/47 , G01N33/569 , G01N33/53 , C12N5/08 , G01N33/566 , G01N33/567
CPC分类号： G01N33/56972 , C07K14/4748 , A61K39/00 , Y10S436/813
摘要： The invention relates to the identification of complexes of HLA-A2 and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
摘要翻译： 本发明涉及在异常细胞表面鉴定HLA-A2和酪氨酸酶衍生肽的复合物。 该观察的治疗和诊断结果是本发明的主题。
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8.发明授权Precursor processed to at least one tumor rejection antigen presented by HLA-A2 失效前体加工成由HLA-A2呈递的至少一种肿瘤排斥抗原
公开(公告)号：US6001975A
公开(公告)日：1999-12-14
申请号：US33881
申请日：1998-03-03
申请人： Vincent Brichard , Aline Van Pel , Catia Traversari , Thomas Wolfel , Thierry Boon-Falleur , Etienne De Plaen
发明人： Vincent Brichard , Aline Van Pel , Catia Traversari , Thomas Wolfel , Thierry Boon-Falleur , Etienne De Plaen
CPC分类号： C07K14/4748 , G01N33/57484
摘要： The invention relates to nucleic acid molecules coding for a tumor rejection antigen precursor. Specifically, the tumor rejection antigen precursor, or `TRAP", is processed into at least one tumor rejection antigen, which is presented by HLA-A2 molecules. Ramifications of the discovery are also set forth.
摘要翻译： 本发明涉及编码肿瘤排斥抗原前体的核酸分子。 具体地，将肿瘤排斥抗原前体或“TRAP”加工成由HLA-A2分子呈递的至少一种肿瘤排斥抗原，还阐述了发现的突变。
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9.发明授权Isolated nucleic acid sequence coding for a tumor rejection antigen precursor processed to at least one tumor rejection antigen presented by HLA-A2 失效编码被HLA-A2呈递至少一种肿瘤排斥抗原的肿瘤排斥抗原前体的分离的核酸序列
公开(公告)号：US5856091A
公开(公告)日：1999-01-05
申请号：US370319
申请日：1995-01-10
申请人： Vincent Brichard , Aline Van Pel , Catia Traversari , Thomas Wolfel , Pierre Coulie , Thierry Boon-Falleur , Etienne De Plaen
发明人： Vincent Brichard , Aline Van Pel , Catia Traversari , Thomas Wolfel , Pierre Coulie , Thierry Boon-Falleur , Etienne De Plaen
IPC分类号： G01N33/50 , A61K35/14 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07H21/04 , C07K14/47 , C07K14/725 , C07K14/74 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/574 , C12N15/11
CPC分类号： G01N33/57484 , C07K14/4748 , C07K14/70539 , A61K38/00 , Y02P20/582
摘要： The invention relates to nucleic acid molecules coding for a tumor rejection antigen precursor. Specifically, the tumor rejection antigen precursor, or "TRAP", is processed into at least one tumor rejection antigen, which is presented by HLA-A2 molecules. Ramifications of the discovery are also set forth.
摘要翻译： 本发明涉及编码肿瘤排斥抗原前体的核酸分子。 具体地，将肿瘤排斥抗原前体或“TRAP”加工成由HLA-A2分子呈递的至少一种肿瘤排斥抗原。 还发现了这一发现的发现。
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公开(公告)号：US5843687A
公开(公告)日：1998-12-01
申请号：US545212
申请日：1995-10-19
IPC分类号： C12N15/09 , A61K35/14 , A61K35/17 , A61K38/00 , A61K38/46 , A61K39/00 , A61K48/00 , A61P35/00 , A61P37/00 , A61P37/02 , C07K7/06 , C07K14/47 , C07K14/74 , C12N5/08 , C12N9/02 , C12P21/02 , C12Q1/04 , C12R1/91 , G01N33/50 , G01N33/569 , G01N33/53 , A61K39/385 , A61K38/04
CPC分类号： G01N33/56972 , A61K35/17 , C07K14/4748 , C07K14/70539 , C12N9/0071 , C12Y114/18001 , G01N33/505 , G01N33/5091 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
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