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公开(公告)号：US5843688A
公开(公告)日：1998-12-01
申请号：US583238
申请日：1996-01-05
申请人： Thomas Wolfel , Aline Van Pel , Vincent Brichard , Thierry Boon-Falleur , Etienne DePlaen , Pierre Coulie , Jean-Christophe Renauld , Bernard Lethe
发明人： Thomas Wolfel , Aline Van Pel , Vincent Brichard , Thierry Boon-Falleur , Etienne DePlaen , Pierre Coulie , Jean-Christophe Renauld , Bernard Lethe
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K39/00 , A61K48/00 , A61K49/00 , A61P43/00 , C07K7/06 , C07K14/47 , C12N5/06 , C12N5/10 , C12N9/02 , C12Q1/02 , G01N33/50 , G01N33/569 , G01N33/53 , A61K38/04 , A61K39/385
CPC分类号： G01N33/56972 , C07K14/4748 , C12N9/0071 , C12Y114/18001 , G01N33/505 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
摘要翻译： 本发明涉及在异常细胞表面鉴定人白细胞抗原分子和酪氨酸酶衍生肽的复合物。 该观察的治疗和诊断结果是本发明的主题。
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公开(公告)号：US5530096A
公开(公告)日：1996-06-25
申请号：US203054
申请日：1994-02-28
申请人： Thomas Wolfel , Aline Van Pel , Vincent Brichard , Thierry Boon-Falleur , Etienne DePlaen , Pierre Coulie , Jean-Christophe Renauld , Bernard Lethe
发明人： Thomas Wolfel , Aline Van Pel , Vincent Brichard , Thierry Boon-Falleur , Etienne DePlaen , Pierre Coulie , Jean-Christophe Renauld , Bernard Lethe
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K39/00 , A61K48/00 , A61K49/00 , A61P43/00 , C07K7/06 , C07K14/47 , C12N5/06 , C12N5/10 , C12N9/02 , C12Q1/02 , G01N33/50 , G01N33/569 , A61K38/08
CPC分类号： G01N33/56972 , C07K14/4748 , C12N9/0071 , C12Y114/18001 , G01N33/505 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
摘要翻译： 本发明涉及在异常细胞表面鉴定人白细胞抗原分子和酪氨酸酶衍生肽的复合物。 该观察的治疗和诊断结果是本发明的主题。
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3.发明授权Isolated nucleic acid molecule encoding peptides which form complexes with MHC molecules HLA-Cw*1601 and uses thereof 失效编码与MHC分子HLA-Cw * 1601形成复合物的肽的分离的核酸分子及其用途公开(公告)号：US06465184B1
公开(公告)日：2002-10-15
申请号：US09435524
申请日：1999-11-08
申请人： Pascale Bo{haeck over (e)}l , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
发明人： Pascale Bo{haeck over (e)}l , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
IPC分类号： C12Q168
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/70539
摘要： A family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了一系列肿瘤排斥抗原前体和编码它们的核酸分子。 这些肿瘤排斥抗原前体被称为BAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为BAGE编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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4.发明授权Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors 失效分离的编码BAGE肿瘤排斥抗原前体的核酸分子
公开(公告)号：US5571711A
公开(公告)日：1996-11-05
申请号：US79110
申请日：1993-06-17
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , C07H21/02 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/74 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91 , C12P19/34 , C12N1/15 , C12N1/19 , C12N5/00 , C12N15/00
CPC分类号： C07K14/4748 , C07K14/70539 , A61K38/00
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为BAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为BAGE编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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5.发明授权Method for treating subjects by using BAGE tumor rejection antigen precursors or tumor rejection antigens 失效通过使用BAGE肿瘤排斥抗原前体或肿瘤排斥抗原治疗受试者的方法公开(公告)号：US06638512B1
公开(公告)日：2003-10-28
申请号：US09382497
申请日：1999-08-25
申请人： Pascale Bo{haeck over (e)}l , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
发明人： Pascale Bo{haeck over (e)}l , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
IPC分类号： A61K3900
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/70539
摘要： A family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了一系列肿瘤排斥抗原前体和编码它们的核酸分子。 这些肿瘤排斥抗原前体被称为BAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为BAGE编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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6.发明授权Isolated nucleic acid molecule encoding peptides which form complexes with MHC molecule HLA-Cw*1601 and uses thereof 失效编码与MHC分子HLA-Cw * 1601形成复合物的肽的分离的核酸分子及其用途
公开(公告)号：US5877017A
公开(公告)日：1999-03-02
申请号：US389360
申请日：1995-02-16
申请人： Pascale Boel , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
发明人： Pascale Boel , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61P35/00 , A61P37/00 , C07H21/02 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/74 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91 , C12N1/15 , C12N1/19
CPC分类号： C07K14/70539 , C07K14/4748 , A61K38/00
摘要： A family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了一系列肿瘤排斥抗原前体和编码它们的核酸分子。 这些肿瘤排斥抗原前体被称为BAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为BAGE编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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7.发明授权Methods for determining complexes of tumor rejection antigens and HLA-Cw*160/molecules 失效确定肿瘤排斥抗原与HLA-Cw * 1601分子复合物的方法
公开(公告)号：US6110694A
公开(公告)日：2000-08-29
申请号：US38328
申请日：1998-03-11
申请人： Pascale Boel , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
发明人： Pascale Boel , Claude Wildmann , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Jean-Christophe Renauld
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , C07H21/02 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/74 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91 , G01N33/574
CPC分类号： C07K14/4748 , C07K14/70539 , A61K38/00
摘要： A family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了一系列肿瘤排斥抗原前体和编码它们的核酸分子。 这些肿瘤排斥抗原前体被称为BAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为BAGE编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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8.发明授权Method for diagnosing a disorder characterized by expression of a BAGE tumor rejection antigen precursor 失效用于诊断以BAGE肿瘤排斥抗原前体的表达为特征的病症的方法
公开(公告)号：US6093540A
公开(公告)日：2000-07-25
申请号：US573186
申请日：1995-12-15
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , C07H21/02 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/74 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/4748 , C07K14/70539 , A61K38/00
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为BAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为BAGE编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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9.发明授权Isolated nucleic acid molecules which encode T cell inducible factors (TIFs), the proteins encoded, and uses thereof 失效编码T细胞诱导因子（TIF）的分离的核酸分子，编码的蛋白质及其用途公开(公告)号：US07972833B2
公开(公告)日：2011-07-05
申请号：US11902473
申请日：2007-09-21
CPC分类号： C07K14/52
摘要： The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid molecules show some structural features of cytokines. In addition to the nucleic acid molecules and the proteins, various uses of the molecules are disclosed. The molecules are referred to as T cell inducible factors.
摘要翻译： 本发明涉及分离核酸分子，其表达被白介素-9上调。 对应于核酸分子的蛋白质的氨基酸序列显示细胞因子的一些结构特征。 除了核酸分子和蛋白质之外，还公开了分子的各种用途。 这些分子被称为T细胞诱导因子。
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公开(公告)号：US07371383B2
公开(公告)日：2008-05-13
申请号：US10412703
申请日：2003-04-11
申请人： Jennifer Lynne Reed , William Dall'Acqua , Jacques Van Snick , Jean-Christophe Renauld , Francoise Cormont , Catherine Uyttenhove
发明人： Jennifer Lynne Reed , William Dall'Acqua , Jacques Van Snick , Jean-Christophe Renauld , Francoise Cormont , Catherine Uyttenhove
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： The application describes neutralizing chimeric and humanized anti-human IL-9 antibodies, and the use thereof to identify neutralizing epitopes on human IL-9 and as medicaments to prevent and treat asthma, bronchial hyperresponsiveness, atopic allergy, and other related disorders. Particularly disclosed are recombinant antibodies derived from three murine anti-human IL-9 antibodies identified infra as MH9A3, MH9D1, and MH9L1.
摘要翻译： 本申请描述了中和嵌合和人源化抗人IL-9抗体，以及其用于鉴定人IL-9上的中和表位以及用于预防和治疗哮喘，支气管高反应性，特应性变态反应和其它相关疾病的药物。 特别公开的是衍生自以下鉴定的三种鼠抗人IL-9抗体作为MH9A3，MH9D1和MH9L1的重组抗体。
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