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    USE OF FOCUSED ULTRASOUND FOR VASCULAR SEALING
    2.
    发明申请
    USE OF FOCUSED ULTRASOUND FOR VASCULAR SEALING 审中-公开
    使用聚焦超声波进行血管密封

    公开(公告)号：US20070179379A1

    公开(公告)日：2007-08-02

    申请号：US11619996

    申请日：2007-01-04

    申请人： Lee Weng ,  David Perozek ,  Jimin Zhang

    发明人： Lee Weng ,  David Perozek ,  Jimin Zhang

    IPC分类号： A61B5/05

    CPC分类号： A61B8/4422 ,  A61B17/0057 ,  A61B2017/00504 ,  A61B2017/00641 ,  A61B2017/00907 ,  A61B2090/062 ,  A61B2090/378 ,  A61B2090/3904 ,  A61B2090/3937 ,  A61B2562/164 ,  A61N7/02 ,  G10K11/32 ,  G10K11/346

    摘要： An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture. The apparatus and method are particularly applicable to sealing a puncture made when inserting a catheter into an artery or other vessel. Several different procedures are described for locating the puncture wound, including imaging the vessel in which the puncture is disposed and use of a locator rod to determine the disposition of the puncture along the longitudinal axis of the artery.

    摘要翻译： 超声波施加器单元（2）用于诊断性地将穿刺伤口（316）定位在动脉中，然后在治疗上定位以用高强度聚焦超声（HIFU）密封穿刺伤口。 耦合到施加器单元的控制单元（6）包括处理器（74），其自动化过程，控制诊断和治疗模式的各种参数，包括施加器单元发射的超声能量的强度和持续时间。 旨在与单个患者一起使用然后被丢弃的保护性无菌声学外壳（4）被滑过施用器单元以防止施用器单元和患者之间的直接接触并且保持无菌区域在 穿刺部位。 该装置和方法特别适用于在将导管插入动脉或其他血管时进行的穿刺的密封。 描述了用于定位穿刺伤口的几种不同的程序，包括对其中设置穿刺的容器进行成像，并使用定位杆来确定沿着动脉的纵向轴线的穿刺的布置。

    Insertable ultrasound probes, systems, and methods for thermal therapy
    3.
    发明申请
    Insertable ultrasound probes, systems, and methods for thermal therapy 审中-公开
    可插入的超声探头，系统和热疗方法

    公开(公告)号：US20050240170A1

    公开(公告)日：2005-10-27

    申请号：US10671417

    申请日：2003-09-24

    申请人： Jimin Zhang ,  David Perozek ,  Lee Weng

    发明人： Jimin Zhang ,  David Perozek ,  Lee Weng

    IPC分类号： A61B17/22 ,  A61B18/04 ,  A61B19/00 ,  A61M20060101 ,  A61N7/02

    CPC分类号： A61N7/022 ,  A61B17/22012 ,  A61B2090/378

    摘要： Disclosed herein are methods and systems for producing hemostasis, tissue closure, or vessel closure by inserting a thermal delivery probe into a passageway and emitting thermal energy from the probe to produce the hemostasis or tissue closure. These methods and systems may be used following a percutaneous medical procedure that creates a passageway in tissue of patient, such as is caused by introduction of an access device into the patient. The thermal delivery probe may have one or more ultrasound transducers positioned in an elongated shaft.

    摘要翻译： 本文公开了通过将热传递探针插入通道并从探针发射热能以产生止血或组织闭合来产生止血，组织闭合或血管闭合的方法和系统。 这些方法和系统可以在经皮医学过程之后使用，该经皮医学程序在患者的组织中产生通道，例如通过将进入装置引入患者而引起的。 热传递探针可以具有定位在细长轴中的一个或多个超声换能器。

    Ultrasound transducers for imaging and therapy
    4.
    发明申请
    Ultrasound transducers for imaging and therapy 审中-公开
    用于成像和治疗的超声换能器

    公开(公告)号：US20060235300A1

    公开(公告)日：2006-10-19

    申请号：US11471052

    申请日：2006-06-19

    申请人： Lee Weng ,  David Perozek ,  Jimin Zhang

    发明人： Lee Weng ,  David Perozek ,  Jimin Zhang

    IPC分类号： A61B8/00 ,  A61H1/00

    CPC分类号： A61B8/4461 ,  A61B8/12 ,  A61B8/445 ,  A61B17/0057 ,  A61B2017/00504 ,  A61B2017/00907 ,  A61B2090/062 ,  A61B2090/378 ,  A61B2090/3904 ,  A61B2090/3937 ,  A61B2562/164 ,  A61H23/0245 ,  A61N7/02 ,  A61N2007/0052 ,  A61N2007/0065 ,  A61N2007/0078 ,  G10K11/32 ,  G10K11/346

    摘要： Ultrasound applicators able to both image a treatment site and administer ultrasound therapy include an array of transducer elements that can be focused. In several embodiments, an electronically phased array is used for controlling the focal point of an ultrasound beam. The ultrasound beam produced thereby can also be electronically steered. To reduce the quality factor or Q of the array when the array is used for imaging, an electronic switch is selectively closed, placing a resistance in parallel with each of the array elements. A flexible array is employed in several embodiments and is selectively bent or flexed to vary its radius of curvature and thus control the focal point and/or a direction of focus of the array. In another embodiment, each of the transducer elements comprising the array are individually mechanically pivotable to steer the ultrasonic beam produced by the transducer elements.

    摘要翻译： 能够对治疗部位进行成像并进行超声治疗的超声波施加器包括可聚焦的换能器元件阵列。 在几个实施例中，电子相控阵列用于控制超声波束的焦点。 由此产生的超声波束也可以被电子控制。 为了在阵列用于成像时降低阵列的质量因子或Q，选择性地关闭电子开关，将电阻与每个阵列元件并联。 在几个实施例中使用柔性阵列并且被选择性地弯曲或弯曲以改变其曲率半径，并且因此控制阵列的焦点和/或焦点的方向。 在另一个实施例中，包括阵列的每个换能器元件分别机械地枢转以转向由换能器元件产生的超声波束。

    Methods and devices to target vascular targets with high intensity focused ultrasound
    6.
    发明授权
    Methods and devices to target vascular targets with high intensity focused ultrasound 有权
    用高强度聚焦超声靶向血管目标的方法和装置

    公开(公告)号：US08277398B2

    公开(公告)日：2012-10-02

    申请号：US13026108

    申请日：2011-02-11

    申请人： Lee Weng ,  David M. Perozek ,  Jimin Zhang

    发明人： Lee Weng ,  David M. Perozek ,  Jimin Zhang

    IPC分类号： A61H1/00

    CPC分类号： A61B8/4422 ,  A61B17/0057 ,  A61B2017/00504 ,  A61B2017/00641 ,  A61B2017/00907 ,  A61B2090/062 ,  A61B2090/378 ,  A61B2090/3904 ,  A61B2090/3937 ,  A61B2562/164 ,  A61N7/02 ,  G10K11/32 ,  G10K11/346

    摘要： An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture. The apparatus and method are particularly applicable to sealing a puncture made when inserting a catheter into an artery or other vessel. Several different procedures are described for locating the puncture wound, including imaging the vessel in which the puncture is disposed and use of a locator rod to determine the disposition of the puncture along the longitudinal axis of the artery.

    摘要翻译： 超声波施加器单元（2）用于诊断性地将穿刺伤口（316）定位在动脉中，然后在治疗上定位以用高强度聚焦超声（HIFU）密封穿刺伤口。 耦合到施加器单元的控制单元（6）包括处理器（74），其自动化过程，控制诊断和治疗模式的各种参数，包括施加器单元发射的超声能量的强度和持续时间。 旨在与单个患者一起使用然后被丢弃的保护性无菌声学外壳（4）被滑过施用器单元以防止施用器单元和患者之间的直接接触并且保持无菌区域在 穿刺部位。 该装置和方法特别适用于在将导管插入动脉或其他血管时进行的穿刺的密封。 描述了用于定位穿刺伤口的几种不同的程序，包括对其中设置穿刺的容器进行成像，并使用定位杆来确定沿着动脉的纵向轴线的穿刺的布置。

    USE OF FOCUSED ULTRASOUND FOR VASCULAR SEALING
    7.
    发明申请
    USE OF FOCUSED ULTRASOUND FOR VASCULAR SEALING 审中-公开
    使用聚焦超声波进行血管密封

    公开(公告)号：US20110021913A1

    公开(公告)日：2011-01-27

    申请号：US12896740

    申请日：2010-10-01

    申请人： Lee Weng ,  David M. Perozek ,  Jimin Zhang

    发明人： Lee Weng ,  David M. Perozek ,  Jimin Zhang

    IPC分类号： A61N7/00 ,  A61B8/00

    CPC分类号： A61B8/4422 ,  A61B17/0057 ,  A61B2017/00504 ,  A61B2017/00641 ,  A61B2017/00907 ,  A61B2090/062 ,  A61B2090/378 ,  A61B2090/3904 ,  A61B2090/3937 ,  A61B2562/164 ,  A61N7/02 ,  G10K11/32 ,  G10K11/346

    摘要： An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture. The apparatus and method are particularly applicable to sealing a puncture made when inserting a catheter into an artery or other vessel. Several different procedures are described for locating the puncture wound, including imaging the vessel in which the puncture is disposed and use of a locator rod to determine the disposition of the puncture along the longitudinal axis of the artery.

    摘要翻译： 超声波施加器单元（2）用于诊断性地将穿刺伤口（316）定位在动脉中，然后在治疗上定位以用高强度聚焦超声（HIFU）密封穿刺伤口。 耦合到施加器单元的控制单元（6）包括处理器（74），其自动化过程，控制诊断和治疗模式的各种参数，包括施加器单元发射的超声能量的强度和持续时间。 旨在与单个患者一起使用然后被丢弃的保护性无菌声学外壳（4）被滑过施用器单元以防止施用器单元和患者之间的直接接触并且保持无菌区域在 穿刺部位。 该装置和方法特别适用于在将导管插入动脉或其他血管时进行的穿刺的密封。 描述了用于定位穿刺伤口的几种不同的程序，包括对其中设置穿刺的容器进行成像，并使用定位杆来确定沿着动脉的纵向轴线的穿刺的布置。

    METHODS AND DEVICES TO TARGET VASCULAR TARGETS WITH HIGH INTENSITY FOCUSED ULTRASOUND
    8.
    发明申请
    METHODS AND DEVICES TO TARGET VASCULAR TARGETS WITH HIGH INTENSITY FOCUSED ULTRASOUND 有权
    用高强度聚焦超声波靶向血管收缩的方法和装置

    公开(公告)号：US20110178445A1

    公开(公告)日：2011-07-21

    申请号：US13026108

    申请日：2011-02-11

    申请人： Lee Weng ,  David M. Perozek ,  Jimin Zhang

    发明人： Lee Weng ,  David M. Perozek ,  Jimin Zhang

    IPC分类号： A61N7/00

    CPC分类号： A61B8/4422 ,  A61B17/0057 ,  A61B2017/00504 ,  A61B2017/00641 ,  A61B2017/00907 ,  A61B2090/062 ,  A61B2090/378 ,  A61B2090/3904 ,  A61B2090/3937 ,  A61B2562/164 ,  A61N7/02 ,  G10K11/32 ,  G10K11/346

    摘要： An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture. The apparatus and method are particularly applicable to sealing a puncture made when inserting a catheter into an artery or other vessel. Several different procedures are described for locating the puncture wound, including imaging the vessel in which the puncture is disposed and use of a locator rod to determine the disposition of the puncture along the longitudinal axis of the artery.

    摘要翻译： 超声波施加器单元（2）用于诊断性地将穿刺伤口（316）定位在动脉中，然后在治疗上定位以用高强度聚焦超声（HIFU）密封穿刺伤口。 耦合到施加器单元的控制单元（6）包括处理器（74），其自动化过程，控制诊断和治疗模式的各种参数，包括施加器单元发射的超声能量的强度和持续时间。 旨在与单个患者一起使用然后被丢弃的保护性无菌声学外壳（4）被滑过施用器单元以防止施用器单元和患者之间的直接接触并且保持无菌区域在 穿刺部位。 该装置和方法特别适用于在将导管插入动脉或其他血管时进行的穿刺的密封。 描述了用于定位穿刺伤口的几种不同的程序，包括对其中设置穿刺的容器进行成像，并使用定位杆来确定沿着动脉的纵向轴线的穿刺的布置。

    FORMATION OF ULTRASOUND BASED HEATING REGIONS ADJACENT BLOOD VESSELS
    9.
    发明申请
    FORMATION OF ULTRASOUND BASED HEATING REGIONS ADJACENT BLOOD VESSELS 审中-公开
    形成超声波加热区域邻近血液容器

    公开(公告)号：US20110066085A1

    公开(公告)日：2011-03-17

    申请号：US12951850

    申请日：2010-11-22

    申请人： Lee Weng ,  David M. Perozek ,  Jimin Zhang

    发明人： Lee Weng ,  David M. Perozek ,  Jimin Zhang

    IPC分类号： A61N7/00

    CPC分类号： A61N7/00 ,  A61B8/12 ,  A61B8/4281 ,  A61B8/445 ,  A61B8/546 ,  A61B2017/4216 ,  A61B2090/378 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0052

    摘要： An ultrasound system used for both imaging and delivery high intensity ultrasound energy therapy to treatment sites and a method for treating tumors and other undesired tissue within a patient's body with an ultrasound device. The ultrasound device has an ultrasound transducer array disposed on a distal end of an elongate, relatively thin shaft. In one form of the invention, the transducer array is disposed within a liquid-filled elastomeric material that more effectively couples ultrasound energy into the tumor, that is directly contacted with the device. Using the device in a continuous wave mode, a necrotic zone of tissue having a desired size and shape (e.g., a necrotic volume selected to interrupt a blood supply to a tumor) can be created by controlling at least one of the f-number, duration, intensity, and direction of the ultrasound energy administered. This method speeds the therapy and avoids continuously pausing to enable intervening normal tissue to cool.

    摘要翻译： 用于成像和递送高强度超声能量治疗到治疗部位的超声系统以及用超声波装置治疗患者体内的肿瘤和其它不需要的组织的方法。 超声波装置具有设置在细长相对薄的轴的远端上的超声换能器阵列。 在本发明的一种形式中，换能器阵列设置在液体填充的弹性体材料内，其更有效地将超声能量耦合到与装置直接接触的肿瘤中。 以连续波模式使用该装置，可以通过控制至少一个f号码，来产生具有期望大小和形状的组织的坏死区（例如，被选择用于中断向肿瘤供血的坏死体积） 持续时间，强度和方向。 这种方法加快了治疗速度，避免了持续暂停，从而使正常组织能够平静地冷却。

    CONTROLLED HIGH EFFICIENCY LESION FORMATION USING HIGH INTENSITY ULTRASOUND
    10.
    发明申请
    CONTROLLED HIGH EFFICIENCY LESION FORMATION USING HIGH INTENSITY ULTRASOUND 失效
    使用高强度超声波控制高效率成像

    公开(公告)号：US20090036774A1

    公开(公告)日：2009-02-05

    申请号：US12247969

    申请日：2008-10-08

    申请人： Lee Weng ,  David M. Perozek ,  Jimin Zhang

    发明人： Lee Weng ,  David M. Perozek ,  Jimin Zhang

    IPC分类号： A61B8/00 ,  A61H1/00 ,  A61B8/14

    CPC分类号： A61N7/00 ,  A61B8/12 ,  A61B8/4281 ,  A61B8/445 ,  A61B8/546 ,  A61B2017/4216 ,  A61B2090/378 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0052

    摘要： An ultrasound system used for both imaging and delivery high intensity ultrasound energy therapy to treatment sites and a method for treating tumors and other undesired tissue within a patient's body with an ultrasound device. The ultrasound device has an ultrasound transducer array disposed on a distal end of an elongate, relatively thin shaft. In one form of the invention, the transducer array is disposed within a liquid-filled elastomeric material that more effectively couples ultrasound energy into the tumor, that is directly contacted with the device. Using the device in a continuous wave mode, a necrotic zone of tissue having a desired size and shape (e.g., a necrotic volume selected to interrupt a blood supply to a tumor) can be created by controlling at least one of the f-number, duration, intensity, and direction of the ultrasound energy administered. This method speeds the therapy and avoids continuously pausing to enable intervening normal tissue to cool.

    摘要翻译： 用于成像和递送高强度超声能量治疗到治疗部位的超声系统以及用超声装置治疗患者体内的肿瘤和其它不需要的组织的方法。 超声波装置具有设置在细长相对薄的轴的远端上的超声换能器阵列。 在本发明的一种形式中，换能器阵列设置在液体填充的弹性体材料内，其更有效地将超声能量耦合到与装置直接接触的肿瘤中。 以连续波模式使用该装置，可以通过控制至少一个f号码，来产生具有期望大小和形状的组织的坏死区（例如，被选择用于中断向肿瘤供血的坏死体积） 持续时间，强度和方向。 这种方法加快了治疗速度，避免了持续暂停，从而使正常组织能够平静地冷却。