公开(公告)号：US20060010239A1

公开(公告)日：2006-01-12

申请号：US10880212

申请日：2004-06-29

申请人： Thomas Bishop ,  Michael Martin ,  James Mott ,  Timothy Smith

发明人： Thomas Bishop ,  Michael Martin ,  James Mott ,  Timothy Smith

IPC分类号： G06F15/16

CPC分类号： G06F9/54 ,  H04L43/0817

摘要： Methods of determining which components and their capacities within a distributed computing environment are used for a transaction type can be performed faster and more accurately compared to conventional methods. In one embodiment by separating the transaction types into groups, regression can be performed faster on data collected because the data is less “polluted” by some or all other transactions types. Also, selection of transaction types within each group can reduce or eliminate colinearities in data between different transaction types. In still another embodiment, the distributed computing environment can be allowed to catch up between running each group of transaction types. Alternatively, if multiple instances of a component are present, transactions may be routed based on transaction type to reduce the impact. Data processing system readable media can include code that includes instructions for carrying out the methods.

摘要翻译： 与传统方法相比，可以更快更准确地确定分配计算环境中哪些组件及其容量用于事务类型的方法。 在一个实施例中，通过将事务类型分成组，可以更快地对所收集的数据执行回归，因为数据被某些或所有其他事务类型的“污染”较少。 此外，每个组内的事务类型的选择可以减少或消除不同事务类型之间的数据中的共线性。 在另一个实施例中，可以允许分布式计算环境在运行每组事务类型之间追赶。 或者，如果组件的多个实例存在，则可以基于事务类型路由事务以减少影响。 数据处理系统可读介质可以包括包括用于执行方法的指令的代码。

公开(公告)号：US20050209833A1

公开(公告)日：2005-09-22

申请号：US10755790

申请日：2004-01-12

申请人： Thomas Bishop ,  Michael Martin ,  Timothy Smith ,  Robert Tulloh ,  David Wilson

发明人： Thomas Bishop ,  Michael Martin ,  Timothy Smith ,  Robert Tulloh ,  David Wilson

IPC分类号： G06F17/10 ,  H04L29/08

CPC分类号： H04L67/22

摘要： Methods and systems of estimating usage of components within an application environment can use statistical, rather than deterministic methods that may be too intrusive or disturb a network used by the application environment. Different transaction types may have estimated usage of components within the application environment and its corresponding confidence level (that the transaction type uses that specific component) calculated and presented to a user. Asynchronous data and data routinely generated by a component may be used. The workload and utilization data may be conditioned before determining the estimated usage to smooth and filter data and determine accuracy of the correlations.

摘要翻译： 估计应用程序环境中组件使用情况的方法和系统可以使用统计而不是确定性的方法，这些方法可能太侵扰或干扰应用程序环境使用的网络。 不同的事务类型可以估计应用程序环境内的组件的使用情况及其对应的置信水平（事务类型使用该特定组件）计算并呈现给用户。 可以使用由组件常规生成的异步数据和数据。 可以在确定用于平滑和过滤数据的估计使用量并确定相关性的准确性之前对工作负载和利用数据进行调节。

公开(公告)号：US20060009954A1

公开(公告)日：2006-01-12

申请号：US10889570

申请日：2004-07-12

申请人： Thomas Bishop ,  Robert Fabbio ,  Michael Martin ,  Jaisimha Muthegere

发明人： Thomas Bishop ,  Robert Fabbio ,  Michael Martin ,  Jaisimha Muthegere

IPC分类号： G06F17/10

CPC分类号： G06Q10/10

摘要： An application or a portion thereof can be thought of as a container having a set of instruments with mathematical descriptions of relationships between the instruments and other portions of the application infrastructure. The set of instruments may include only those instruments determined to significantly affect or be significantly affected by an application or a portion thereof running within a distributed computing environment. Models can be generated to include those instruments that significantly affect or are significantly affected by the application or a portion thereof and their mathematical descriptions of relationships between those instruments. By using the models, portions of an application environment across tiers can be controlled in a more coherent manner to better achieve the business objectives of an organization. The methods and systems can also help to identify and correct potential problems that may not be seen when examining tiers or sub-tiers individually.

摘要翻译： 应用或其一部分可以被认为是具有一组仪器的容器，其具有仪器与应用基础设施的其它部分之间的关​​系的数学描述。 该组仪器可以仅包括确定为在分布式计算环境中运行的应用或其部分显着影响或显着影响的仪器。 可以生成模型以包括显着影响或受应用程序或其一部分的显着影响的仪器及其对这些仪器之间的关系的数学描述。 通过使用模型，跨层的应用程序环境的一部分可以以更一致的方式进行控制，以更好地实现组织的业务目标。 这些方法和系统还可以帮助识别和纠正在单独检查层次或子层时可能看不到的潜在问题。

公开(公告)号：US20050198398A1

公开(公告)日：2005-09-08

申请号：US10761909

申请日：2004-01-21

申请人： Thomas Bishop ,  Michael Martin ,  Robert Tulloh

发明人： Thomas Bishop ,  Michael Martin ,  Robert Tulloh

IPC分类号： H04L12/24 ,  G06F15/16

CPC分类号： H04L41/0893 ,  H04L41/00 ,  H04L41/0233 ,  H04L41/0816

摘要： Methods and systems of managing a network can be used in which physical components may be provisioned or de-provisioned without having to manually reconfigure a logical instrument. Logical instruments may be used to monitor or control an application environment. The logical instruments may be coupled to logical objects, which in turn are coupled to physical model objects, which in turn correspond to physical components. Host agents may reside on the physical components to actuate or have actuated a physical component. From a perspective of an operator or a program optimizing or otherwise managing an application environment on a network, the logical instruments appear as static variables (values can change, but the variable itself does not) where dynamic changes to physical components may occur but are transparent to the operator or program.

摘要翻译： 可以使用管理网络的方法和系统，其中物理组件可以被配置或去除，而不必手动重新配置逻辑仪器。 逻辑仪器可用于监控或控制应用环境。 逻辑仪器可以耦合到逻辑对象，逻辑对象又耦合到物理模型对象，物理模型对象又对应于物理组件。 主机代理可以驻留在物理组件上以致动或激活物理组件。 从运营商或程序优化或以其他方式管理网络上的应用程序环境的角度来看，逻辑工具显示为静态变量（值可以更改，但变量本身不会），其中物理组件的动态更改可能会发生但透明 给操作员或程序。

公开(公告)号：US20050256945A1

公开(公告)日：2005-11-17

申请号：US10746806

申请日：2003-12-24

申请人： Michael Martin ,  Jaisimha Muthegere ,  Timothy Smith ,  Robert Tulloh

发明人： Michael Martin ,  Jaisimha Muthegere ,  Timothy Smith ,  Robert Tulloh

IPC分类号： G06F15/173 ,  H04L12/24

CPC分类号： H04L41/147

摘要： A system and method can use statistical modeling of the way that an entire application environment is running. The output from the statistical models can be used by an optimization engine to provide an optimal or near optimal configuration and operation of the application environment for nearly any workloads and conditions. After constructing the statistical models, the operation can be entirely automated and not require human intervention. In another embodiment, some human intervention may be used or desired, particularly for non-reoccurring events (e.g., significant portion of a network for the application environment shut down due to a natural disaster). The system and method can be used to respond faster (closer to real time) and potentially to implement better control than would otherwise be possible with manual control. The system and method is particularly well suited for application environments that are in a nearly constant state of flux.

摘要翻译： 系统和方法可以使用整个应用程序环境运行方式的统计建模。 统计模型的输出可以由优化引擎使用，为几乎任何工作负载和条件提供最佳或接近最优的应用环境配置和操作。 构建统计模型后，操作可以完全自动化，不需要人为干预。 在另一个实施例中，可以使用或期望一些人为干预，特别是对于非重复事件（例如，由于自然灾害而使应用环境关闭的网络的重要部分）。 该系统和方法可以用于响应更快（更接近实时）），并且潜在地实现比手动控制可能的更好的控制。 该系统和方法特别适用于处于几乎恒定的通量状态的应用环境。

公开(公告)号：US08048454B2

公开(公告)日：2011-11-01

申请号：US10598671

申请日：2005-03-09

申请人： Michael Martin

发明人： Michael Martin

IPC分类号： A61K33/14 ,  A61K33/00 ,  A61P43/00 ,  A61P31/04

CPC分类号： A61K33/14 ,  Y02A50/402 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/423 ,  Y02A50/469 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/479 ,  Y02A50/481 ,  Y02A50/483 ,  Y10S514/921

摘要： This invention relates generally to a method of treating inflammation and associated diseases and disorders by administering an agent that inhibits glycogen synthase kinase 3 activity.

摘要翻译： 本发明一般涉及通过施用抑制糖原合酶激酶3活性的药物来治疗炎症和相关疾病和病症的方法。

公开(公告)号：US20100322698A1

公开(公告)日：2010-12-23

申请号：US12486562

申请日：2009-06-17

申请人： Michael Martin

发明人： Michael Martin

IPC分类号： B43K23/02

CPC分类号： B43K23/02 ,  B43K7/005 ,  B43K7/02 ,  B43K23/04 ,  B43K29/00

摘要： The writing instrument mountable to a ferrous surface includes an ink barrel of a non-ferrous material and first and second ends, an interior ink receiving space defined by an interior surface thereof, and a longitudinally extending axis. An agitator is positioned within the interior ink receiving space and is freely slidable therein for reciprocation along the longitudinally extending axis. The agitator includes a continuously open passage extending therethrough and generally in a direction from the first end towards the second end of the ink barrel. The agitator is a permanent magnet, whereby the writing instrument is detachably mountable to a surface of a ferrous material by a magnetic attraction between the surface of a ferrous material and the agitator when the ink barrel is positioned against the surface of a ferrous material.

摘要翻译： 可安装到黑色金属表面的书写工具包括有色金属材料的墨桶和第一和第二端，由其内表面限定的内部墨水容纳空间和纵向延伸的轴线。 搅拌器定位在内部油墨接收空间内并且可自由地在其中滑动以沿着纵向延伸的轴线往复运动。 搅拌器包括一个连续打开的通道，其通过其延伸，并且大致在从墨桶的第一端到第二端的方向上。 搅拌器是永久磁铁，借此当墨水筒靠着铁质材料的表面定位时，书写工具可以通过铁质材料表面和搅拌器之间的磁吸引力而可拆卸地安装到铁质材料的表面上。

公开(公告)号：US20100236341A1

公开(公告)日：2010-09-23

申请号：US12406756

申请日：2009-03-18

申请人： Michael Martin ,  Kevin Walsh ,  Julia Aebersold ,  R. Andrew McGill ,  Stanley V. Stepnowski

发明人： Michael Martin ,  Kevin Walsh ,  Julia Aebersold ,  R. Andrew McGill ,  Stanley V. Stepnowski

IPC分类号： G01N1/40 ,  G01N1/02

CPC分类号： G01N1/405 ,  G01N2001/022

摘要： An analyte collection system device includes an active area that includes a plurality of perforations extending therethrough. The plurality of perforations are arranged to permit passage of an analyte fluid flow through the microscale plate. A heating element is provided for heating the active area, and a thermal distribution layer is disposed over at least a portion of the active area. For cooling the active area at or below an ambient temperature, an active cooler is provided.

摘要翻译： 分析物收集系统装置包括有效区域，其包括穿过其中延伸的多个穿孔。 多个穿孔布置成允许分析物流体流通过微尺度板。 提供加热元件以加热有源区域，并且热分布层设置在有源区域的至少一部分上。 为了在环境温度或低于环境温度下冷却有源区域，提供有源冷却器。

公开(公告)号：US20090249958A1

公开(公告)日：2009-10-08

申请号：US12337449

申请日：2008-12-17

申请人： Scott Cambron ,  Thomas Roussel ,  Robert Keynton ,  Michael Martin ,  Kevin Walsh ,  Doug Jackson ,  John Naber

发明人： Scott Cambron ,  Thomas Roussel ,  Robert Keynton ,  Michael Martin ,  Kevin Walsh ,  Doug Jackson ,  John Naber

IPC分类号： B01D50/00

CPC分类号： G01N1/405 ,  G01N30/08 ,  G01N35/1095

摘要： An interchangeable preconcentrator assembly comprises an outer housing and an inner housing defining a chamber. A biased urging member is held at least partially within the outer housing and slidably biased toward a surface of the inner housing. When the biased urging member is at least partially retracted, a space is defined between the urging member and the surface of the inner housing for accommodating at least one preconcentrator chip. A continuous fluid flow path is defined through the outer housing and through the space. The interchangeable preconcentrator assembly may further comprise at least one modular preconcentrator carriage.

摘要翻译： 可互换的预浓缩器组件包括外壳体和限定腔室的内壳体。 偏压推动构件至少部分地保持在外壳体内并且可滑动地偏压到内壳体的表面。 当偏压推动构件至少部分地缩回时，在推动构件和内壳体的表面之间限定一个空间，用于容纳至少一个预浓缩器芯片。 连续的流体流动路径通过外部壳体并通过该空间来限定。 可互换的预浓缩器组件还可以包括至少一个模块化预浓缩器托架。

公开(公告)号：US20070169342A1

公开(公告)日：2007-07-26

申请号：US11690595

申请日：2007-03-23

申请人： Noah Lassar ,  Mohammad Akhavain ,  Michael Martin

发明人： Noah Lassar ,  Mohammad Akhavain ,  Michael Martin

IPC分类号： H05K3/00

CPC分类号： H05K1/111 ,  H01L2924/00013 ,  H05K1/0306 ,  H05K2201/09418 ,  H05K2201/09427 ,  H05K2201/09709 ,  H05K2201/10674 ,  Y02P70/611 ,  Y10T29/49147 ,  Y10T29/49149 ,  Y10T29/49165 ,  H01L2224/29099

摘要： In an implementation of connection pad layouts, a connection assembly includes a substrate assembly and connection pads disposed thereon. The connection pads form a configuration such that each connection pad is configured to align with a different terminal of an interconnect that is warped or otherwise has a non-linear alignment of terminals.

摘要翻译： 在连接焊盘布局的实现中，连接组件包括衬底组件和设置在其上的连接焊盘。 连接焊盘形成这样的配置，使得每个连接焊盘被配置成与被弯曲的互连的不同端子对齐或者具有端子的非线性对准。