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公开(公告)号：US07235045B2
公开(公告)日：2007-06-26
申请号：US10393028
申请日：2003-03-20
CPC分类号： G01J3/4406 , A61B1/00009 , A61B1/0005 , A61B1/043 , A61B1/05 , A61B1/07 , A61B5/0071 , A61B5/0084 , A61B5/415 , A61B5/418 , G01J3/02 , G01J3/0232 , G01J3/10 , G01N21/6456 , G01N2021/6417 , G01N2021/6421 , G01N2021/6484
摘要： An endoscope having an optical guide that is optically coupled to a first broadband light source and a second laser light source that emits light at a wavelength in a range of 350 nm to 420 nm. The endoscope has an image sensor at a distal end and collects a reflectance image including red, green and blue components with the image sensor in response to illumination by said broadband light source. The image sensor also collects an autofluorescence image having a blue component, a green component and a red component. A processor processes the fluorescence image by determining a ratio of the fluorescence image and the reflectance image to provide a processed fluorescence image.
摘要翻译： 一种具有与第一宽带光源光学耦合的光导的内窥镜和发射在350nm至420nm范围内的波长的光的第二激光光源。 内窥镜在远端具有图像传感器，并响应于所述宽带光源的照明，利用图像传感器收集包括红色，绿色和蓝色分量的反射图像。 图像传感器还收集具有蓝色分量，绿色分量和红色分量的自发荧光图像。 处理器通过确定荧光图像和反射率图像的比例来处理荧光图像以提供经处理的荧光图像。
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公开(公告)号：US06537211B1
公开(公告)日：2003-03-25
申请号：US09238664
申请日：1999-01-26
IPC分类号： A61B106
CPC分类号： G01J3/4406 , A61B1/00009 , A61B1/0005 , A61B1/043 , A61B1/05 , A61B1/07 , A61B5/0071 , A61B5/0084 , A61B5/415 , A61B5/418 , G01J3/02 , G01J3/0232 , G01J3/10 , G01N21/6456 , G01N2021/6417 , G01N2021/6421 , G01N2021/6484
摘要： The present invention relates to a fluorescence endoscope imaging system. The system uses first and second light sources to provide fluorescence and reflectance images of tissue being examined. The imaging system also includes an electronic controller that actuates the illumination of the system by switching current through the first light source between a first illumination level and a second illumination level such that the tissue is illuminated at the first or second illumination level. An imaging device mounted at the distal end of the device is used to collect both images.
摘要翻译： 本发明涉及一种荧光内窥镜成像系统。 该系统使用第一和第二光源来提供正在检查的组织的荧光和反射图像。 成像系统还包括电子控制器，其通过在第一照明水平和第二照明水平之间切换通过第一光源的电流来致动系统的照明，使得组织以第一或第二照明水平照亮。 安装在设备远端的成像装置用于收集两个图像。
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公开(公告)号：US07846091B2
公开(公告)日：2010-12-07
申请号：US10092033
申请日：2002-03-05
申请人： Stephen F. Fulghum
发明人： Stephen F. Fulghum
CPC分类号： A61B1/0638 , A61B1/00009 , A61B1/00126 , A61B1/043 , A61B1/0646 , A61B1/0669 , A61B1/07 , A61B5/0071 , A61B5/0084
摘要： A system and method for imaging tissue autofluorescence through a video endoscope is described, comprising a light source capable of providing both ultraviolet light capable of inducing tissue autofluorescence and visible light which induces little or no autofluorescence, an optical system to deliver both wavelength bands to the tissue with the same apparent spatial and angular intensity distribution, a means for digitally acquiring the resulting, visible fluorescence and visible reflectance images using a single imaging detector at the distal tip of the endoscope and a means for digitally processing said images to generate a final, false-color image for display which indicates regions of tissue dysplasia. This system can either be added on to an existing video endoscope or integrated into its structure. The combined system can be electronically switched between normal white light imaging and fluorescence imaging.
摘要翻译： 描述了一种用于通过视频内窥镜成像组织自体荧光的系统和方法，包括能够提供能够诱导组织自发荧光的紫外光和诱发很少或没有自发荧光的可见光的光源，将两个波长带传送到 具有相同表观空间和角度强度分布的组织，用于使用在内窥镜的远侧末端处的单个成像检测器数字获取所得到的可见荧光和可见反射图像的装置，以及用于数字处理所述图像以产生最终， 用于显示的伪彩色图像，其指示组织发育不良的区域。 该系统可以添加到现有的视频内窥镜上或集成到其结构中。 组合系统可以在正常白光成像和荧光成像之间进行电子切换。
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公开(公告)号：US06364829B1
公开(公告)日：2002-04-02
申请号：US09362806
申请日：1999-07-28
申请人： Stephen F. Fulghum
发明人： Stephen F. Fulghum
IPC分类号： A61B106
CPC分类号： A61B5/0084 , A61B1/00009 , A61B1/00126 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B1/07 , A61B5/0071 , A61B5/0075
摘要： A system and method for imaging tissue autofluorescence through a video endoscope is described, comprising a light source capable of providing both ultraviolet light capable of inducing tissue autofluorescence and visible light which induces little or no autofluorescence, an optical system to deliver both wavelength bands to the tissue with the same apparent spatial and angular intensity distribution, a means for digitally acquiring the resulting, visible fluorescence and visible reflectance images using a single imaging detector at the distal tip of the endoscope and a means for digitally processing said images to generate a final, false-color image for display which indicates regions of tissue dysplasia. This system can either be added on to an existing video endoscope or integrated into its structure. The combined system can be electronically switched between normal white light imaging and fluorescence imaging.
摘要翻译： 描述了一种用于通过视频内窥镜成像组织自体荧光的系统和方法，包括能够提供能够诱导组织自发荧光的紫外光和诱发很少或没有自发荧光的可见光的光源，将两个波长带传送到 具有相同表观空间和角度强度分布的组织，用于使用在内窥镜的远侧末端处的单个成像检测器数字获取所得到的可见荧光和可见反射图像的装置，以及用于数字处理所述图像以产生最终， 用于显示的伪彩色图像，其指示组织发育不良的区域。 该系统可以添加到现有的视频内窥镜上或集成到其结构中。 组合系统可以在正常白光成像和荧光成像之间进行电子切换。
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公开(公告)号：US08764643B2
公开(公告)日：2014-07-01
申请号：US12955327
申请日：2010-11-29
申请人： Stephen F. Fulghum
发明人： Stephen F. Fulghum
CPC分类号： A61B1/0638 , A61B1/00009 , A61B1/00126 , A61B1/043 , A61B1/0646 , A61B1/0669 , A61B1/07 , A61B5/0071 , A61B5/0084
摘要： A system and method for imaging tissue autofluorescence through a video endoscope is described, comprising a light source capable of providing both ultraviolet light capable of inducing tissue autofluorescence and visible light which induces little or no autofluorescence, an optical system to deliver both wavelength bands to the tissue with the same apparent spatial and angular intensity distribution, a means for digitally acquiring the resulting, visible fluorescence and visible reflectance images using a single imaging detector at the distal tip of the endoscope and a means for digitally processing said images to generate a final, false-color image for display which indicates regions of tissue dysplasia. This system can either be added on to an existing video endoscope or integrated into its structure. The combined system can be electronically switched between normal white light imaging and fluorescence imaging.
摘要翻译： 描述了一种用于通过视频内窥镜成像组织自体荧光的系统和方法，包括能够提供能够诱导组织自发荧光的紫外光和诱发很少或没有自发荧光的可见光的光源，将两个波长带传送到 具有相同表观空间和角度强度分布的组织，用于使用在内窥镜的远侧末端处的单个成像检测器数字获取所得到的可见荧光和可见反射图像的装置，以及用于数字处理所述图像以产生最终， 用于显示的伪彩色图像，其指示组织发育不良的区域。 该系统可以添加到现有的视频内窥镜上或集成到其结构中。 组合系统可以在正常白光成像和荧光成像之间进行电子切换。
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公开(公告)号：US20110213252A1
公开(公告)日：2011-09-01
申请号：US12955327
申请日：2010-11-29
申请人： Stephen F. Fulghum
发明人： Stephen F. Fulghum
IPC分类号： A61B6/00
CPC分类号： A61B1/0638 , A61B1/00009 , A61B1/00126 , A61B1/043 , A61B1/0646 , A61B1/0669 , A61B1/07 , A61B5/0071 , A61B5/0084
摘要： A system and method for imaging tissue autofluorescence through a video endoscope is described, comprising a light source capable of providing both ultraviolet light capable of inducing tissue autofluorescence and visible light which induces little or no autofluorescence, an optical system to deliver both wavelength bands to the tissue with the same apparent spatial and angular intensity distribution, a means for digitally acquiring the resulting, visible fluorescence and visible reflectance images using a single imaging detector at the distal tip of the endoscope and a means for digitally processing said images to generate a final, false-color image for display which indicates regions of tissue dysplasia. This system can either be added on to an existing video endoscope or integrated into its structure. The combined system can be electronically switched between normal white light imaging and fluorescence imaging.
摘要翻译： 描述了一种用于通过视频内窥镜成像组织自体荧光的系统和方法，包括能够提供能够诱导组织自发荧光的紫外光和诱发很少或没有自发荧光的可见光的光源，将两个波长带传送到 具有相同表观空间和角度强度分布的组织，用于使用在内窥镜的远侧末端处的单个成像检测器数字获取所得到的可见荧光和可见反射图像的装置，以及用于数字处理所述图像以产生最终， 用于显示的伪彩色图像，其指示组织发育不良的区域。 该系统可以添加到现有的视频内窥镜上或集成到其结构中。 组合系统可以在正常白光成像和荧光成像之间进行电子切换。
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