USE OF PROBIOTICS TO AMELIORATE DIET-INDUCED INSULIN RESISTANCE
    2.
    发明申请
    USE OF PROBIOTICS TO AMELIORATE DIET-INDUCED INSULIN RESISTANCE 审中-公开
    使用益生菌来改善胰岛素诱导的胰岛素抵抗

    公开(公告)号:US20120027737A1

    公开(公告)日:2012-02-02

    申请号:US13256852

    申请日:2010-03-19

    摘要: The invention relates to the use of a composition comprising probiotic bacteria that regulate expression of key components involved in diet-induced insulin resistance for ameliorating or preventing diet-induced insulin resistance. The use of the probiotic strain and/or a fraction of said strain and/or metabolite of said strain for the manufacture of a medicament or a food or feed product to ameliorate diet-induced insulin resistance and help to obtain optimal body weight of a mammal is disclosed. Preferably, the composition comprises at least one probiotic Lactobacillus acidophilus strain and/or a fraction of said strain and/or metabolite of said strain for ameliorating or preventing diet-induced insulin resistance, said composition characterized by up-regulating expression of the ANGPTL4 gene encoding for FIAF in the intestine, down-regulating expression of the Elovl6 gene in the intestine as well as down-regulating expression of the SCD1 gene in skeletal muscles of a mammal, and wherein the probiotic strain is selected from the group of strains consisting of Lactobacillus acidophilus strain LA-5 (DSM13241).

    摘要翻译: 本发明涉及包含调节饮食诱导的胰岛素抵抗的关键成分的表达以改善或预防饮食诱导的胰岛素抵抗的益生菌的组合物的用途。 益生菌菌株和/或所述菌株和/或所述菌株的代谢物的一部分用于制造药物或食品或饲料产品以改善饮食诱导的胰岛素抵抗并有助于获得哺乳动物的最佳体重 被披露。 优选地,组合物包含至少一种益生菌嗜酸乳杆菌菌株和/或所述菌株和/或所述菌株的代谢物的级分,用于改善或预防饮食诱导的胰岛素抵抗,所述组合物的特征在于上调编码的ANGPTL4基因的表达 用于肠内的FIAF,下调Elovl6基因在肠中的表达,以及下调哺乳动物骨骼肌中SCD1基因的表达,其中益生菌菌株选自乳杆​​菌属 嗜酸菌菌株LA-5(DSM13241)。

    Fermented milk or vegetable proteins comprising receptor ligand and uses thereof
    3.
    发明授权
    Fermented milk or vegetable proteins comprising receptor ligand and uses thereof 失效
    包含受体配体的发酵乳或植物蛋白及其用途

    公开(公告)号:US07883697B1

    公开(公告)日:2011-02-08

    申请号:US11660659

    申请日:2005-09-05

    摘要: The present invention relates to the use of compositions comprising receptor ligands obtainable by a process comprising fermenting a food material, comprising animal milk or vegetable proteins, with lactic acid bacteria to obtain a fermented food or feed material that comprises ligands of specific adrenoreceptors and/or serotonin receptors. The fermented food or feed material is useful e.g. for reducing and/or stabilizing heart rate in a mammal. It may furthermore be used for treatment and/or relief of erectile dysfunctions and for treatment and/or relief of benign prostate hypertrophy (BPH), in a mammal.

    摘要翻译: 本发明涉及使用包含受体配体的组合物的用途,所述组合物可通过包括用乳酸菌发酵包含动物乳或植物蛋白质的食物材料以获得包含特定肾上腺素受体的配体的发酵食物或饲料的方法和/或 血清素受体。 发酵食品或饲料是有用的,例如 用于减少和/或稳定哺乳动物的心率。 此外还可用于哺乳动物治疗和/或缓解勃起功能障碍和用于治疗和/或缓解良性前列腺肥大(BPH)。

    Reducing heart rate in mammals using milk derived fermentation products produced using Lactobacillus helveticus
    4.
    发明授权
    Reducing heart rate in mammals using milk derived fermentation products produced using Lactobacillus helveticus 有权
    使用使用瑞士乳杆菌产生的使用乳汁的发酵产品降低哺乳动物的心率

    公开(公告)号:US07718171B2

    公开(公告)日:2010-05-18

    申请号:US10819275

    申请日:2004-04-07

    IPC分类号: A61K35/00

    摘要: Use of a composition obtainable by a process comprising fermenting a food material, comprising animal milk or vegetable proteins, with a lactic acid bacterium to obtain a fermented food material which comprises active components with heart rate reducing properties for the manufacture of a product for reducing the heart rate and/or the fluctuations in the heart rate of a mammalian.

    摘要翻译: 使用通过包括发酵包含动物乳或植物蛋白质的食物材料与乳酸菌的方法获得的组合物,以获得发酵食品材料,其包含具有降低心率的活性成分,用于制造用于减少 心率和/或哺乳动物心率的波动。

    Fermented milk or vegetable proteins comprising receptor ligand and uses thereof
    5.
    发明授权
    Fermented milk or vegetable proteins comprising receptor ligand and uses thereof 有权
    包含受体配体的发酵乳或植物蛋白及其用途

    公开(公告)号:US08367604B2

    公开(公告)日:2013-02-05

    申请号:US13021392

    申请日:2011-02-04

    IPC分类号: A61K38/17 A61P9/00 A61P15/10

    摘要: The present invention relates to the use of compositions comprising receptor ligands obtainable by a process comprising fermenting a food material, comprising animal milk or vegetable proteins, with lactic acid bacteria to obtain a fermented food or feed material that comprises ligands of specific adrenoreceptors and/or serotonin receptors. The fermented food or feed material is useful e.g. for reducing and/or stabilizing heart rate in a mammal. It may furthermore be used for treatment and/or relief of erectile dysfunctions and for treatment and/or relief of benign prostate hypertrophy (BPH), in a mammal.

    摘要翻译: 本发明涉及使用包含受体配体的组合物的用途,所述组合物可通过包括用乳酸菌发酵包含动物乳或植物蛋白质的食物材料以获得包含特定肾上腺素受体的配体的发酵食物或饲料的方法和/或 血清素受体。 发酵食品或饲料是有用的,例如 用于减少和/或稳定哺乳动物的心率。 此外还可用于哺乳动物治疗和/或缓解勃起功能障碍和用于治疗和/或缓解良性前列腺肥大(BPH)。