公开(公告)号：US08603023B2

公开(公告)日：2013-12-10

申请号：US13105029

申请日：2011-05-11

申请人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, Jr. ,  Jason L. Harris ,  Christopher J. Hess ,  Thomas W. Huitema ,  John V. Hunt ,  Prasanna Malaviya ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Foster B. Stulen ,  James W. Voegele ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, Jr. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

发明人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, Jr. ,  Jason L. Harris ,  Christopher J. Hess ,  Thomas W. Huitema ,  John V. Hunt ,  Prasanna Malaviya ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Foster B. Stulen ,  James W. Voegele ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, Jr. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

IPC分类号： A61M5/00 ,  A61M29/00

CPC分类号： A61F5/0076 ,  A61F2/04 ,  A61F5/0013 ,  A61F5/0026 ,  A61F5/0079 ,  A61F2002/045

摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems, and ingestible pills. In one embodiment, the implantable system comprises a device delivering a therapeutic substance to a target location within the gastrointestinal tract of a patient in order to initiate an intestinal braking effect which would promote sensations of satiety and stimulate excess weight loss for the patient.

摘要翻译： 方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。 这些方法和装置通过稳定的可植入系统和可摄取的药丸来实现。 在一个实施方案中，可植入系统包括将治疗物质递送到患者胃肠道内的目标位置的装置，以便开始肠促动作用，其将促进饱腹感，并刺激患者多余的体重减轻。

公开(公告)号：US20110295180A1

公开(公告)日：2011-12-01

申请号：US13105029

申请日：2011-05-11

申请人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, JR. ,  Jason L. Harris ,  Christopher J. Hess ,  Thomas W. Huitema ,  John V. Hunt ,  Prasanna Malaviya ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Foster B. Stulen ,  James W. Voegele ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, JR. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

发明人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, JR. ,  Jason L. Harris ,  Christopher J. Hess ,  Thomas W. Huitema ,  John V. Hunt ,  Prasanna Malaviya ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Foster B. Stulen ,  James W. Voegele ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, JR. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

IPC分类号： A61F2/04

CPC分类号： A61F5/0076 ,  A61F2/04 ,  A61F5/0013 ,  A61F5/0026 ,  A61F5/0079 ,  A61F2002/045

摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems, and ingestible pills. In one embodiment, the implantable system comprises a device delivering a therapeutic substance to a target location within the gastrointestinal tract of a patient in order to initiate an intestinal braking effect which would promote sensations of satiety and stimulate excess weight loss for the patient.

摘要翻译： 方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。 这些方法和装置通过稳定的可植入系统和可摄取的药丸来实现。 在一个实施方案中，可植入系统包括将治疗物质递送到患者胃肠道内的目标位置的装置，以便开始肠促动作用，其将促进饱腹感，并刺激患者多余的体重减轻。

公开(公告)号：US08876761B2

公开(公告)日：2014-11-04

申请号：US13104313

申请日：2011-05-10

申请人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, Jr. ,  Jason L. Harris ,  Christopher J. Hess ,  Prasanna Malaviya ,  Glenda C. Marsh ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  James W. Voegele ,  Lauren S. Weaner ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, Jr. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

发明人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, Jr. ,  Jason L. Harris ,  Christopher J. Hess ,  Prasanna Malaviya ,  Glenda C. Marsh ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  James W. Voegele ,  Lauren S. Weaner ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, Jr. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

IPC分类号： A61M31/00 ,  A61K9/00 ,  A61M5/142 ,  A61F5/00 ,  A61N1/05 ,  A61M39/02 ,  A61F2/04 ,  A61N1/36 ,  A61N1/372

CPC分类号： A61M31/002 ,  A61F2/04 ,  A61F5/0013 ,  A61F5/0026 ,  A61F2002/045 ,  A61K9/0065 ,  A61M5/14276 ,  A61M39/0208 ,  A61M2210/106 ,  A61M2210/1064 ,  A61N1/0509 ,  A61N1/36007 ,  A61N1/37205

摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems and ingestible pills. In one embodiment, a method of producing satiety comprising the steps of accessing a gastrointestinal tract of a patient and implanting an intraintestinal therapeutic substance eluting implant. The implant is capable of eluting a satiety inducing substance selected from at least one of a nutrient, a specific satiety inducing bio-active substance, pancreatic polypeptides, free fatty acids, cholecystokinin, amino acids, glutamine, lipids, linoleic acid, or a combination thereof, from the implant into the gastrointestinal tract.

摘要翻译： 方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。 这些方法和装置通过稳定的可植入系统和可摄取的药丸来实现。 在一个实施方案中，产生饱腹感的方法包括以下步骤：进入患者的胃肠道并植入肠内治疗物质洗脱植入物。 植入物能够洗脱选自营养物，特定饱腹感生物活性物质，胰腺多肽，游离脂肪酸，缩胆囊素，氨基酸，谷氨酰胺，脂质，亚油酸或组合中的至少一种的饱腹感受物质 从植入物到胃肠道。

公开(公告)号：US20110295185A1

公开(公告)日：2011-12-01

申请号：US13104313

申请日：2011-05-10

申请人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, JR. ,  Jason L. Harris ,  Christopher J. Hess ,  Prasanna Malaviya ,  Glenda C. Marsh ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  James W. Voegele ,  Lauren S. Weaner ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, JR. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

发明人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, JR. ,  Jason L. Harris ,  Christopher J. Hess ,  Prasanna Malaviya ,  Glenda C. Marsh ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  James W. Voegele ,  Lauren S. Weaner ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, JR. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

IPC分类号： A61M37/00 ,  A61K31/20 ,  A61M5/00 ,  A61F2/00 ,  A61M5/168 ,  A61N1/36

CPC分类号： A61M31/002 ,  A61F2/04 ,  A61F5/0013 ,  A61F5/0026 ,  A61F2002/045 ,  A61K9/0065 ,  A61M5/14276 ,  A61M39/0208 ,  A61M2210/106 ,  A61M2210/1064 ,  A61N1/0509 ,  A61N1/36007 ,  A61N1/37205

摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems and ingestible pills. In one embodiment, a method of producing satiety comprising the steps of accessing a gastrointestinal tract of a patient and implanting an intraintestinal therapeutic substance eluting implant. The implant is capable of eluting a satiety inducing substance selected from at least one of a nutrient, a specific satiety inducing bio-active substance, pancreatic polypeptides, free fatty acids, cholecystokinin, amino acids, glutamine, lipids, linoleic acid, or a combination thereof, from the implant into the gastrointestinal tract.

摘要翻译： 方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。 这些方法和装置通过稳定的可植入系统和可摄取的药丸来实现。 在一个实施方案中，产生饱腹感的方法包括以下步骤：进入患者的胃肠道并植入肠内治疗物质洗脱植入物。 植入物能够洗脱选自营养物，特定饱腹感生物活性物质，胰腺多肽，游离脂肪酸，缩胆囊素，氨基酸，谷氨酰胺，脂质，亚油酸或组合中的至少一种的饱腹感受物质 从植入物到胃肠道。

公开(公告)号：US20110295178A1

公开(公告)日：2011-12-01

申请号：US13104321

申请日：2011-05-10

申请人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Gregory J. Bakos ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, JR. ,  Jason L. Harris ,  Christopher J. Hess ,  John V. Hunt ,  Prasanna Malaviya ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Suzanne Thompson ,  Richard W. Timm ,  James W. Voegele ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, JR. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

发明人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Gregory J. Bakos ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, JR. ,  Jason L. Harris ,  Christopher J. Hess ,  John V. Hunt ,  Prasanna Malaviya ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Suzanne Thompson ,  Richard W. Timm ,  James W. Voegele ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, JR. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

IPC分类号： A61M5/00

CPC分类号： A61F5/0079 ,  A61K9/0065 ,  A61M5/14276 ,  A61M31/002 ,  A61M39/0208 ,  A61M2210/106 ,  A61M2210/1064

摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices may be accomplished via stabilized implantable systems and ingestible pills. In one aspect, a method of inducing satiety includes implanting an implant within a lumen of a gastrointestinal tract and retaining a portion of chyme that flows by the implant within a body of the implant. The method further involves re-releasing the retained chyme from the implant into the gastrointestinal tract at a predetermined rate slower than a rate caused by natural peristalsis.

摘要翻译： 方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。 这些方法和装置可以通过稳定的可植入系统和可摄取的药丸来实现。 一方面，一种诱导饱腹感的方法包括将植入物植入胃肠道的内腔中，并且将植入物流动的部分保持在植入物的体内。 该方法还包括以比由天然蠕动引起的速率慢的预定速率将留置的食糜从植入物再释放到胃肠道中。

公开(公告)号：US08636751B2

公开(公告)日：2014-01-28

申请号：US13104192

申请日：2011-05-10

申请人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, Jr. ,  Jason L. Harris ,  Christopher J. Hess ,  Kevin L. Houser ,  Mario Gutierrez ,  Prasanna Malaviya ,  Amy L. Marcotte ,  Jeffrey D. Messerly ,  Anthony Nguyen ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Foster B. Stulen ,  James W. Voegele ,  Lauren S. Weaner ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, Jr. ,  Mark S. Zeiner

发明人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, Jr. ,  Jason L. Harris ,  Christopher J. Hess ,  Kevin L. Houser ,  Mario Gutierrez ,  Prasanna Malaviya ,  Amy L. Marcotte ,  Jeffrey D. Messerly ,  Anthony Nguyen ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Foster B. Stulen ,  James W. Voegele ,  Lauren S. Weaner ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, Jr. ,  Mark S. Zeiner

IPC分类号： A61B17/10

CPC分类号： A61B17/00234 ,  A61B5/0031 ,  A61B5/036 ,  A61B5/073 ,  A61B5/076 ,  A61B5/1107 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/42 ,  A61B17/0469 ,  A61B17/1114 ,  A61B2017/00876 ,  A61B2017/1117 ,  A61B2017/1139 ,  A61B2560/0219 ,  A61F2/04 ,  A61F5/0013 ,  A61F2002/045

摘要： Methods and devices reroute chyme to induce intestinal brake in order to improve the effectiveness of bariatric surgical procedures and to improve comorbidity resolution. A bowel is manipulated to provide a shortened path for chyme to travel to the ileum. These methods and devices of rerouting chyme to induce intestinal brake may include one or more of a surgical procedure, an implanted device, or a combination of an implant with an improved surgical procedure.

摘要翻译： 方法和装置重新路由食糜诱导肠道制动，以提高减肥手术的有效性和改善共病分解。 肠道被操纵以提供用于食糜行进到回肠的缩短路径。 用于诱导肠内制动器的这些重新路由食糜的方法和装置可以包括外科手术，植入装置或具有改进的外科手术的植入物的组合中的一种或多种。

公开(公告)号：US20110295055A1

公开(公告)日：2011-12-01

申请号：US13104192

申请日：2011-05-10

申请人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, JR. ,  Jason L. Harris ,  Christopher J. Hess ,  Kevin L. Houser ,  Mario Gutierrez ,  Prasanna Malaviya ,  Amy L. Marcotte ,  Jeffrey D. Messerly ,  Anthony Nguyen ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Foster B. Stulen ,  James W. Voegele ,  Lauren S. Weaner ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, JR. ,  Mark S. Zeiner

发明人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, JR. ,  Jason L. Harris ,  Christopher J. Hess ,  Kevin L. Houser ,  Mario Gutierrez ,  Prasanna Malaviya ,  Amy L. Marcotte ,  Jeffrey D. Messerly ,  Anthony Nguyen ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Foster B. Stulen ,  James W. Voegele ,  Lauren S. Weaner ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, JR. ,  Mark S. Zeiner

IPC分类号： A61B17/00 ,  A61F2/04

CPC分类号： A61B17/00234 ,  A61B5/0031 ,  A61B5/036 ,  A61B5/073 ,  A61B5/076 ,  A61B5/1107 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/42 ,  A61B17/0469 ,  A61B17/1114 ,  A61B2017/00876 ,  A61B2017/1117 ,  A61B2017/1139 ,  A61B2560/0219 ,  A61F2/04 ,  A61F5/0013 ,  A61F2002/045

摘要： Methods and devices reroute chyme to induce intestinal brake in order to improve the effectiveness of bariatric surgical procedures and to improve comorbidity resolution. A bowel is manipulated to provide a shortened path for chyme to travel to the ileum. These methods and devices of rerouting chyme to induce intestinal brake may comprise one or more of a surgical procedure, an implanted device, or a combination of an implant with an improved surgical procedure.

摘要翻译： 方法和装置重新路由食糜诱导肠道制动，以提高减肥手术的有效性和改善共病分解。 肠道被操纵以提供用于食糜行进到回肠的缩短路径。 用于诱导肠内制动器的重新路由食糜的这些方法和装置可以包括外科手术，植入装置或具有改进的外科手术的植入物的组合中的一种或多种。

公开(公告)号：US20110295337A1

公开(公告)日：2011-12-01

申请号：US13105262

申请日：2011-05-11

申请人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Edward G. Chekan ,  Sean P. Conlon ,  Michael S. Cropper ,  Daniel F. Dlugos, JR. ,  Jason L. Harris ,  Christopher J. Hess ,  Kevin L. Houser ,  John V. Hunt ,  Gary L. Long ,  Prasanna Malaviya ,  Amy L. Marcotte ,  Rudolph H. Nobis ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  David N. Plescia ,  Galen C. Robertson ,  Randy J. Seeley ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Foster B. Stulen ,  Richard W. Timm ,  James W. Voegele ,  William B. Weisenburgh, II ,  James A. Woodard, JR. ,  David C. Yates ,  Andrew M. Zwolinski

发明人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Edward G. Chekan ,  Sean P. Conlon ,  Michael S. Cropper ,  Daniel F. Dlugos, JR. ,  Jason L. Harris ,  Christopher J. Hess ,  Kevin L. Houser ,  John V. Hunt ,  Gary L. Long ,  Prasanna Malaviya ,  Amy L. Marcotte ,  Rudolph H. Nobis ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  David N. Plescia ,  Galen C. Robertson ,  Randy J. Seeley ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Foster B. Stulen ,  Richard W. Timm ,  James W. Voegele ,  William B. Weisenburgh, II ,  James A. Woodard, JR. ,  David C. Yates ,  Andrew M. Zwolinski

IPC分类号： A61N1/36

CPC分类号： A61N1/00 ,  A61F5/0026 ,  A61N1/0509 ,  A61N1/327 ,  A61N1/36007

摘要： A method for regulating hormone production comprises placing at least one electrode in a gastrointestinal tract of a patient and recording an electrical signal during a preselected event produced by the gastrointestinal tract. The method further involves the steps of storing the electrical signal, and playing back the electrical signal by activating the electrode during the absence of the preselected event.

摘要翻译： 用于调节激素产生的方法包括将至少一个电极放置在患者的胃肠道中，并在由胃肠道产生的预选事件期间记录电信号。 该方法还包括存储电信号的步骤，以及在没有预选事件期间激活电极来播放电信号。

公开(公告)号：US20120165793A1

公开(公告)日：2012-06-28

申请号：US12976745

申请日：2010-12-22

申请人： Mark S. Ortiz ,  Christopher J. Hess ,  Jason L. Harris ,  James T. Spivey ,  Michael J. Stokes ,  Thomas E. Albrecht ,  James W. Voegele ,  William B. Weisenburgh, II ,  Rudolph H. Nobis ,  Mark S. Zeiner ,  Mark D. Overmyer ,  Darrel M. Powell ,  Joseph Bernard Kraimer ,  James Anthony Topich ,  Jeremy David Jarrett ,  Daniel James Prenger ,  Matthew D. Rohr Daniel

发明人： Mark S. Ortiz ,  Christopher J. Hess ,  Jason L. Harris ,  James T. Spivey ,  Michael J. Stokes ,  Thomas E. Albrecht ,  James W. Voegele ,  William B. Weisenburgh, II ,  Rudolph H. Nobis ,  Mark S. Zeiner ,  Mark D. Overmyer ,  Darrel M. Powell ,  Joseph Bernard Kraimer ,  James Anthony Topich ,  Jeremy David Jarrett ,  Daniel James Prenger ,  Matthew D. Rohr Daniel

IPC分类号： A61K9/22

CPC分类号： A61M31/002 ,  A61B1/041

摘要： Devices and related methods are provided for the controlled delivery of a therapeutic to a targeted location within a body. More particularly, methods and devices are provided for controlling the rate of passage of an orally administered pill through a body, as well as for controlling the delivery of a therapeutic within the pill at a specific location within the body. Various types of devices, generally referred to herein as “catchers,” are provided that can actively catch a pill as it passes through a body. The catcher can hold the pill at a specific location within the body until a predetermined event occurs, such as partial or complete administration of a therapeutic within the pill. The catcher can then release the pill upon command and/or upon the occurrence of the predetermined event to allow the pill to pass out of the body. In other embodiments, various types of pills are provided that can actively engage a catcher and remain engaged with the catcher until a predetermined event occurs.

摘要翻译： 提供了设备和相关方法，用于将治疗剂控制递送到身体内的目标位置。 更具体地，提供了用于控制经口给药的药丸通过身体的速率的方法和装置，以及用于控制体内在特定位置处的丸剂内的治疗剂的递送。 提供了在本文中通常被称为“捕获器”的各种类型的装置，其可以在通过身体时主动地捕捉药丸。 捕获器可以将药丸保持在体内的特定位置，直到发生预定事件，例如在丸中部分或完全施用治疗剂。 然后，捕手可以在命令和/或发生预定事件时释放药片以允许药丸从身体中流出。 在其他实施例中，提供了可以主动地接合捕获器并保持与捕获器接合的各种类型的药丸，直到发生预定事件。

公开(公告)号：US08118820B2

公开(公告)日：2012-02-21

申请号：US11394174

申请日：2006-03-31

申请人： Michael J. Stokes ,  Thomas E. Albrecht ,  Mark S. Ortiz ,  Mark S. Zeiner ,  Andrew M. Zwolinski ,  Frederick E. Shelton, IV

发明人： Michael J. Stokes ,  Thomas E. Albrecht ,  Mark S. Ortiz ,  Mark S. Zeiner ,  Andrew M. Zwolinski ,  Frederick E. Shelton, IV

IPC分类号： A61B17/04

CPC分类号： A61B17/0469

摘要： A method for inserting an instrument through a natural orifice. The instrument has a low profile orientation and a deployed orientation which is larger than the size of the natural orifice through which it is to be inserted. The method is achieved by coupling the instrument to an endoscope and placing the instrument in its low profile orientation, inserting the endoscope and the instrument through a natural orifice to a target position within a body while the instrument is in its low profile orientation, actuating the instrument to it is deployed orientation, and returning the instrument to its low profile orientation and withdrawing the instrument from the body through the natural orifice.

摘要翻译： 一种通过天然孔口插入仪器的方法。 仪器具有低轮廓取向和展开方向，其大于被插入的自然孔的尺寸。 该方法通过将仪器连接到内窥镜并将仪器置于其低轮廓取向来实现，其中，当仪器处于其低剖面取向时，将内窥镜和仪器通过自然孔口插入到身体内的目标位置，致动 仪器部署方向，并将仪器返回到其低调方向，并将仪器从身体通过自然孔抽出。