公开(公告)号：US09574189B2

公开(公告)日：2017-02-21

申请号：US12095778

申请日：2006-12-01

申请人： Thomas Franch ,  Mikkel Dybro Lundorf ,  Søren Nyboe Jacobsen ,  Eva Kampmann Olsen ,  Anne Lee Andersen ,  Anette Holtmann ,  Anders Holm Hansen ,  Anders Malling Sørensen ,  Anne Goldbech ,  Daen de Leon ,  Ditte Kievsmose Kaldor ,  Frank Abildgaard Sløk ,  Gitte Nystrup Husemoen ,  Johannes Dolberg ,  Kim Birkebæ Jensen ,  Lene Pedersen ,  Mads Nørregaard-Madsen ,  Michael Anders Godskesen ,  Sanne Schrøder Glad ,  Søren Neve ,  Thomas Thisted ,  Tine Titilola Akinleminu Kronborg ,  Christian Klarner Sams ,  Jakob Felding ,  Per-Ola Freskgård ,  Alex Haahr Gouliaev ,  Henrik Pedersen

发明人： Thomas Franch ,  Mikkel Dybro Lundorf ,  Søren Nyboe Jacobsen ,  Eva Kampmann Olsen ,  Anne Lee Andersen ,  Anette Holtmann ,  Anders Holm Hansen ,  Anders Malling Sørensen ,  Anne Goldbech ,  Daen de Leon ,  Ditte Kievsmose Kaldor ,  Frank Abildgaard Sløk ,  Gitte Nystrup Husemoen ,  Johannes Dolberg ,  Kim Birkebæ Jensen ,  Lene Pedersen ,  Mads Nørregaard-Madsen ,  Michael Anders Godskesen ,  Sanne Schrøder Glad ,  Søren Neve ,  Thomas Thisted ,  Tine Titilola Akinleminu Kronborg ,  Christian Klarner Sams ,  Jakob Felding ,  Per-Ola Freskgård ,  Alex Haahr Gouliaev ,  Henrik Pedersen

IPC分类号： C12N15/10 ,  C40B40/08 ,  C40B50/04 ,  C40B50/06

CPC分类号： C12N15/1068 ,  C12N15/1089 ,  C40B40/08 ,  C40B50/04 ,  C40B50/06

摘要： Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

摘要翻译： 公开了一种获得包含与单链标识符寡核苷酸连接的分子的双功能复合物的方法，其中包含化学反应位点的新生双功能复合物和用于酶标记添加的引发位点是a）在化学反应位点与 一种或多种反应物，和b）在起始位点用一种或多种标记反应物的标签进行酶促反应。

公开(公告)号：US20090264300A1

公开(公告)日：2009-10-22

申请号：US12095778

申请日：2006-12-01

申请人： Thomas Franch ,  Mikkel Dybro Lundorf ,  Soren Nyboe Jacobsen ,  Eva Kampmann Olsen ,  Anne Lee Andersen ,  Anette Holtmann ,  Anders Holm Hansen ,  Anders Malling Sorensen ,  Anne Goldbech ,  Daen de Leon ,  Ditte Kievsmose Kaldor ,  Frank Abildgaard Slok ,  Gitte Nystrup Husemoen ,  Johannes Dolberg ,  Kim Birkebaek Jensen ,  Lene Pedersen ,  Mads Norregaard-Madsen ,  Michael Anders Godskesen ,  Sanne Schroder Glad ,  Sore Neve ,  Thomas Thisted ,  Tine Titilola Akinleminu Kronborg ,  Christian Klarner Sams ,  Jakob Felding ,  Per-Ola Freskgard ,  Alex Haahr Gouliaev ,  Henrik Pedersen

发明人： Thomas Franch ,  Mikkel Dybro Lundorf ,  Soren Nyboe Jacobsen ,  Eva Kampmann Olsen ,  Anne Lee Andersen ,  Anette Holtmann ,  Anders Holm Hansen ,  Anders Malling Sorensen ,  Anne Goldbech ,  Daen de Leon ,  Ditte Kievsmose Kaldor ,  Frank Abildgaard Slok ,  Gitte Nystrup Husemoen ,  Johannes Dolberg ,  Kim Birkebaek Jensen ,  Lene Pedersen ,  Mads Norregaard-Madsen ,  Michael Anders Godskesen ,  Sanne Schroder Glad ,  Sore Neve ,  Thomas Thisted ,  Tine Titilola Akinleminu Kronborg ,  Christian Klarner Sams ,  Jakob Felding ,  Per-Ola Freskgard ,  Alex Haahr Gouliaev ,  Henrik Pedersen

IPC分类号： C40B20/04 ,  C40B50/06 ,  C40B40/06 ,  C07H21/00

CPC分类号： C12N15/1068 ,  C12N15/1089 ,  C40B40/08 ,  C40B50/04 ,  C40B50/06

摘要： Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

摘要翻译： 公开了一种获得包含与单链标识符寡核苷酸连接的分子的双功能复合物的方法，其中包含化学反应位点的新生双功能复合物和用于酶标记添加的引发位点是a）在化学反应位点与 一种或多种反应物，和b）在起始位点用一种或多种标记反应物的标签进行酶促反应。