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公开(公告)号:US07727713B2
公开(公告)日:2010-06-01
申请号:US10175539
申请日:2002-06-20
申请人: Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
发明人: Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
CPC分类号: C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
摘要: The present invention relates to a method for synthesizing templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
摘要翻译: 本发明涉及一种合成模板分子的方法。 在本发明的一个方面,模板分子连接到模板,其模板化其合成。 该内容允许生成可以被筛选的文库。 治疗活动。
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公开(公告)号:US08932992B2
公开(公告)日:2015-01-13
申请号:US12330709
申请日:2008-12-09
申请人: Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
发明人: Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
CPC分类号: C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
摘要: The present invention relates to a method for synthesizing templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
摘要翻译: 本发明涉及一种合成模板分子的方法。 在本发明的一个方面,模板分子连接到模板,其模板化其合成。 该内容允许生成可以被筛选的文库。 治疗活动。
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公开(公告)号:US07217554B2
公开(公告)日:2007-05-15
申请号:US10639194
申请日:2003-08-11
申请人: Mads Nørregaard-Madsen , Peter Rahbek Østergaard , Claus Bo Vøge Christensen , Søren Flensted Lassen
发明人: Mads Nørregaard-Madsen , Peter Rahbek Østergaard , Claus Bo Vøge Christensen , Søren Flensted Lassen
摘要: The present invention relates to isolated proteases of the RP-II type and variants of RP-II proteases exhibiting improved properties in comparison to the parent RP-II protease, DNA constructs and vectors coding for the expression of said proteases and variants, host cells capable of expressing the proteases and variants from the DNA constructs, as well as a method of producing them by cultivating said host cells. The proteases may advantageously be used as constituents in detergent compositions and additives, optionally in combination with other enzymes such as proteases, lipases, cellulases, amylases, peroxidases or oxidases.
摘要翻译: 本发明涉及RP-II型分离的蛋白酶和与亲本RP-II蛋白酶相比表现出改进性质的RP-II蛋白酶的变体,DNA构建体和编码所述蛋白酶和变体的表达的载体,具有宿主细胞能力 从DNA构建体表达蛋白酶和变体,以及通过培养所述宿主细胞产生它们的方法。 蛋白酶可以有利地用作洗涤剂组合物和添加剂中的组分,任选地与其它酶如蛋白酶,脂肪酶,纤维素酶,淀粉酶,过氧化物酶或氧化酶组合使用。
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公开(公告)号:US06893855B2
公开(公告)日:2005-05-17
申请号:US09976414
申请日:2001-10-12
CPC分类号: C12N9/54 , C11D3/38681
摘要: The present invention relates to subtilase variants having a reduced tendency towards inhibition by substances present in eggs, such as trypsin inhibitor type IV-0. In particular, the variants comprise at least one additional amino acid residue between positions 42-43, 51-56, 155-161, 187-190, 216-217, 217-218 or 218-219 (in BASBPN numbering). These subtilase variants are useful exhibiting excellent or improved wash performance on egg stains when used in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dishwash composition, including automatic dishwash compositions. Also, isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention. Further, cleaning and detergent compositions comprising the variants are disclosed.
摘要翻译: 本发明涉及具有减少鸡蛋中存在的物质的抑制倾向的减毒酶变体,例如IV-0型胰蛋白酶抑制剂。 特别地,所述变体包含位置42-43,51-56,155-161,187-190,216-217,217-218或218-219之间的至少一个另外的氨基酸残基(以BASBPN编号)。 这些枯草芽孢杆菌变体在用于例如蛋白质时在蛋渍上表现出优异或改善的洗涤性能是有用的。 清洁剂或洗涤剂组合物,例如衣物洗涤剂组合物和洗涤剂组合物,包括自动洗碗剂组合物。 而且,编码变体,分离的载体,宿主细胞的分离的DNA序列和用于产生和使用本发明的变体的方法。 此外,公开了包含变体的清洁剂和洗涤剂组合物。
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5.
公开(公告)号:US09574189B2
公开(公告)日:2017-02-21
申请号:US12095778
申请日:2006-12-01
申请人: Thomas Franch , Mikkel Dybro Lundorf , Søren Nyboe Jacobsen , Eva Kampmann Olsen , Anne Lee Andersen , Anette Holtmann , Anders Holm Hansen , Anders Malling Sørensen , Anne Goldbech , Daen de Leon , Ditte Kievsmose Kaldor , Frank Abildgaard Sløk , Gitte Nystrup Husemoen , Johannes Dolberg , Kim Birkebæ Jensen , Lene Pedersen , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Søren Neve , Thomas Thisted , Tine Titilola Akinleminu Kronborg , Christian Klarner Sams , Jakob Felding , Per-Ola Freskgård , Alex Haahr Gouliaev , Henrik Pedersen
发明人: Thomas Franch , Mikkel Dybro Lundorf , Søren Nyboe Jacobsen , Eva Kampmann Olsen , Anne Lee Andersen , Anette Holtmann , Anders Holm Hansen , Anders Malling Sørensen , Anne Goldbech , Daen de Leon , Ditte Kievsmose Kaldor , Frank Abildgaard Sløk , Gitte Nystrup Husemoen , Johannes Dolberg , Kim Birkebæ Jensen , Lene Pedersen , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Søren Neve , Thomas Thisted , Tine Titilola Akinleminu Kronborg , Christian Klarner Sams , Jakob Felding , Per-Ola Freskgård , Alex Haahr Gouliaev , Henrik Pedersen
CPC分类号: C12N15/1068 , C12N15/1089 , C40B40/08 , C40B50/04 , C40B50/06
摘要: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
摘要翻译: 公开了一种获得包含与单链标识符寡核苷酸连接的分子的双功能复合物的方法,其中包含化学反应位点的新生双功能复合物和用于酶标记添加的引发位点是a)在化学反应位点与 一种或多种反应物,和b)在起始位点用一种或多种标记反应物的标签进行酶促反应。
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公开(公告)号:US20110152155A1
公开(公告)日:2011-06-23
申请号:US13038717
申请日:2011-03-02
CPC分类号: C12N9/54 , C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/38627 , C11D3/38636 , C11D3/38645 , C11D3/38654 , C11D11/0017 , C11D11/0023 , C12N9/50 , C12N9/52 , C12Y304/21062
摘要: The present invention relates to novel subtilase variants exhibiting alterations relative to the parent subtilase in one or more properties including: Wash performance, thermal stability, storage stability or catalytic activity. The variants of the invention are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dishwash compositions, including automatic dishwash compositions.
摘要翻译: 本发明涉及在一种或多种性质中显示相对于亲本脱羧酶的改变的新型脱羧酶变体,包括:洗涤性能,热稳定性,储存稳定性或催化活性。 本发明的变体适用于例如, 清洁剂或洗涤剂组合物,例如衣物洗涤剂组合物和洗碟组合物,包括自动洗碗组合物。
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公开(公告)号:US06558939B1
公开(公告)日:2003-05-06
申请号:US09551826
申请日:2000-04-17
申请人: Mads Nørregaard-Madsen , Peter Rahbek Østergaard , Claus Bo Vøge Christensen , Søren Flensted Lassen
发明人: Mads Nørregaard-Madsen , Peter Rahbek Østergaard , Claus Bo Vøge Christensen , Søren Flensted Lassen
IPC分类号: C12N956
摘要: Novel isolated proteases of the RP-II type and variants of RP-II proteases exhibiting improved properties in comparison to the parent RP-II protease, DNA constructs and vectors coding for the expression of said proteases and variants, host cells capable of expressing the proteases and variants from the DNA constructs, as well as a method of producing them by cultivating said host cells. The proteases may advantageously be used as constituents in detergent compositions and additives, optionally in combination with other enzymes such as proteases, lipases, cellulases, amylase, peroxidases or oxidases.
摘要翻译: 与亲代RP-II蛋白酶,DNA构建体和编码所述蛋白酶和变体的表达的载体相比,RP-II型的新型分离的蛋白酶和RP-II蛋白酶的变体表现出改善的性质,能够表达蛋白酶的宿主细胞 和DNA构建体的变体,以及通过培养所述宿主细胞产生它们的方法。 蛋白酶可以有利地用作洗涤剂组合物和添加剂中的组分,任选地与其它酶如蛋白酶,脂肪酶,纤维素酶,淀粉酶,过氧化物酶或氧化酶组合使用。
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