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    SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY
    1.
    发明申请
    SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY 审中-公开
    具有丝氨酸和/或非诺贝宁活性的取代的苯乙烯

    公开(公告)号：US20080234257A1

    公开(公告)日：2008-09-25

    申请号：US12048012

    申请日：2008-03-13

    申请人： Thomas G. Gant ,  Sepehr Sarshar ,  Soon Hyung Woo

    发明人： Thomas G. Gant ,  Sepehr Sarshar ,  Soon Hyung Woo

    IPC分类号： A61K31/537 ,  C07C211/27 ,  A61K31/14 ,  C07K14/705 ,  A61K31/137 ,  C07D265/16

    摘要： Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, attention deficit hyperactivity disorder, fibromyalgia, irritable bowel syndrome, and/or premature ejaculation are described.

    摘要翻译： 用于治疗和/或治疗精神病症，焦虑障碍，广泛性焦虑症，抑郁症，创伤后应激障碍，强迫症的单胺神经递质及其药学上可接受的盐和前药的新型抑制剂的化学合成和医学用途， 强迫症，恐慌症，热潮红，老年痴呆，偏头痛，肝肺综合征，慢性疼痛，伤害性疼痛，神经性疼痛，疼痛性糖尿病性视网膜病变，双相抑郁症，阻塞性睡眠呼吸暂停，精神疾病，经前焦虑症，社交恐惧症，社交焦虑症 ，尿失禁，厌食症，神经性贪食症，肥胖症，缺血，头部损伤，脑细胞中的钙超载，药物依赖，注意缺陷多动障碍，纤维肌痛，肠易激综合征和/或早泄。

    PREPARATION AND UTILITY OF SUBSTITUTED CARBOXYLIC ACID COMPOUNDS
    2.
    发明申请
    PREPARATION AND UTILITY OF SUBSTITUTED CARBOXYLIC ACID COMPOUNDS 审中-公开
    取代的羧酸化合物的制备和应用

    公开(公告)号：US20070276042A1

    公开(公告)日：2007-11-29

    申请号：US11752238

    申请日：2007-05-22

    申请人： Thomas G. Gant ,  Sepehr Sarshar ,  Soon Hyung Woo

    发明人： Thomas G. Gant ,  Sepehr Sarshar ,  Soon Hyung Woo

    IPC分类号： A61K31/192 ,  C07C57/30

    CPC分类号： C07C57/30 ,  C07B2200/05 ,  C07C57/40 ,  C07C59/64

    摘要： The present disclosure is directed to modulators of cyclooxygenase (COX) enzymes and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of the severity and duration of non-specific pain, tension-type pain, headache, migraine, lower back pain, sciatica, dental pain, muscular pain, pain associated with acute soft tissue injuries, bursitis, tendonitis, lumbago, periarthritis, tennis elbow, sprains, strains, muscular problems associated with sports injuries, muscular problems associated with accidents, period pain, primary dysmenorrhoea, acute sore throat pain, osteoarthritis, rheumatoid arthritis, cancer, any disorder requiring analgesic response, any disorder requiring anti-inflammatory response, any disorder requiring antipyretic response, any conditions mediated by cyclooxygenase, cystic fibrosis, dementia, Alzheimer's disease, and/or conditions mediated by levels of β-amyloid are described.

    摘要翻译： 本公开涉及环氧合酶（COX）酶及其药学上可接受的盐和前药的调节剂，其化学合成以及这些化合物用于治疗和/或治疗非特异性疼痛的严重性和持续时间的医学用途 ，紧张型疼痛，头痛，偏头痛，下背痛，坐骨神经痛，牙痛，肌肉疼痛，与急性软组织损伤相关的疼痛，滑囊炎，腱炎，腰痛，关节炎，网球肘，扭伤，应变，与运动相关的肌肉问题 伤害，与事故相关的肌肉问题，周期性疼痛，原发性痛经，急性喉痛，骨关节炎，类风湿性关节炎，癌症，需要镇痛反应的任何疾病，需要抗炎反应的任何疾病，需要解热反应的任何病症，任何由 环氧合酶，囊性纤维化，痴呆，阿尔茨海默病和/或由β-戊基水平介导的病症 描述了oid。

    Preparation and utility of substituted imidazopyridine compounds with hypnotic effects
    4.
    发明授权
    Preparation and utility of substituted imidazopyridine compounds with hypnotic effects 有权
    具有催眠作用的取代咪唑并吡啶化合物的制备和应用

    公开(公告)号：US07772248B2

    公开(公告)日：2010-08-10

    申请号：US11755634

    申请日：2007-05-30

    申请人： Thomas G. Gant ,  Sepehr Sarshar

    发明人： Thomas G. Gant ,  Sepehr Sarshar

    IPC分类号： A61K31/4745 ,  A61K31/4184 ,  C07D235/02 ,  C07D471/02

    CPC分类号： C07D471/04

    摘要： The present disclosure is directed to modulators of GABAA receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of sleep disorders and/or for providing a patient in need with a hypnotic, anxiolytic or anti-convulsive effect are described.

    摘要翻译： 本公开涉及GABA A受体及其药学上可接受的盐和前药的调节剂，其化学合成以及这些化合物用于治疗和/或治疗睡眠障碍和/或提供需要的患者的医学用途 描述了催眠，抗焦虑或抗惊厥作用。

    Substituted amino alcohols
    5.
    发明授权
    Substituted amino alcohols 有权
    取代的氨基醇

    公开(公告)号：US07767860B2

    公开(公告)日：2010-08-03

    申请号：US12203581

    申请日：2008-09-03

    申请人： Thomas G. Gant ,  Sepehr Sarshar

    发明人： Thomas G. Gant ,  Sepehr Sarshar

    IPC分类号： C07C215/18 ,  A61K31/131

    CPC分类号： C07B59/001 ,  C07B2200/05 ,  C07C215/14

    摘要： Disclosed herein are substituted amino alcohol anti-mycobacterial agents and/or chelation therapy agents of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.

    摘要翻译： 本文公开了式I的取代的氨基醇抗分枝杆菌和/或螯合治疗剂，其制备方法，其药物组合物及其使用方法。