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    Laser shock peening of medical devices
    4.
    发明申请
    Laser shock peening of medical devices 失效
    医疗器械的激光冲击硬化

    公开(公告)号：US20050182478A1

    公开(公告)日：2005-08-18

    申请号：US10778841

    申请日：2004-02-13

    申请人： Thomas Holman ,  Jan Weber

    发明人： Thomas Holman ,  Jan Weber

    IPC分类号： A61F2/00 ,  A61F2/06 ,  A61F2/90 ,  C21D10/00

    CPC分类号： C21D10/005 ,  A61F2/91 ,  A61F2250/0068

    摘要： A laser shock peening process for producing one or more compressive residual stress regions in a medical device is disclosed. A high-energy laser apparatus can be utilized to direct an intense laser beam through a confining medium and onto the target surface of a workpiece. An absorption overlay disposed on the target surface of the workpiece absorbs the laser beam, inducing a pressure shock wave that forms a compressive residual stress region deep within the workpiece. Medical devices such as stents and guidewires having one or more of these compressive residual stress regions are also disclosed.

    摘要翻译： 公开了一种用于在医疗装置中产生一个或多个压缩残余应力区域的激光冲击硬化方法。 可以使用高能激光装置将强激光束引导通过约束介质和工件的目标表面。 设置在工件的目标表面上的吸收层吸收激光束，引起在工件内部形成压缩残余应力区域的压力冲击波。 还公开了具有这些压缩残余应力区域中的一个或多个的支架和导线的医疗装置。

    Laser shock peening of medical devices
    5.
    发明授权
    Laser shock peening of medical devices 失效
    医疗器械的激光冲击硬化

    公开(公告)号：US08049137B2

    公开(公告)日：2011-11-01

    申请号：US10778841

    申请日：2004-02-13

    申请人： Thomas Holman ,  Jan Weber

    发明人： Thomas Holman ,  Jan Weber

    IPC分类号： B23K26/00

    CPC分类号： C21D10/005 ,  A61F2/91 ,  A61F2250/0068

    摘要： A laser shock peening process for producing one or more compressive residual stress regions in a medical device is disclosed. A high-energy laser apparatus can be utilized to direct an intense laser beam through a confining medium and onto the target surface of a workpiece. An absorption overlay disposed on the target surface of the workpiece absorbs the laser beam, inducing a pressure shock wave that forms a compressive residual stress region deep within the workpiece. Medical devices such as stents and guidewires having one or more of these compressive residual stress regions are also disclosed.

    摘要翻译： 公开了一种用于在医疗装置中产生一个或多个压缩残余应力区域的激光冲击硬化方法。 可以使用高能激光装置将强激光束引导通过约束介质和工件的目标表面。 设置在工件的目标表面上的吸收层吸收激光束，引起在工件内部形成压缩残余应力区域的压力冲击波。 还公开了具有这些压缩残余应力区域中的一个或多个的支架和导线的医疗装置。

    Non-foreshortening sheaths and assemblies for use
    6.
    发明申请
    Non-foreshortening sheaths and assemblies for use 审中-公开
    非缩短护套和组件使用

    公开(公告)号：US20070208408A1

    公开(公告)日：2007-09-06

    申请号：US11368913

    申请日：2006-03-06

    申请人： Jan Weber ,  Thomas Holman

    发明人： Jan Weber ,  Thomas Holman

    IPC分类号： A61F2/06

    CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2/966 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2210/0076 ,  A61F2230/0013

    摘要： A catheter assembly comprises a catheter shaft having a device receiving portion, an expandable balloon disposed about the device receiving portion, and a sheath. The sheath has an outer surface and an inner surface defining an inner lumen. The outer surface and inner surface has a sheath wall extending there between. The outer surface has slits therethrough which extend into the sheath wall. The sheath has an expanded state and an unexpanded state such that the sheath maintains the substantially same longitudinal length in the expanded state and the unexpanded state.

    摘要翻译： 导管组件包括具有装置接收部分的导管轴，围绕装置接收部分设置的可膨胀气囊和护套。 护套具有限定内腔的外表面和内表面。 外表面和内表面具有在其之间延伸的护套壁。 外表面具有穿过其的狭缝，其延伸到鞘壁中。 鞘具有膨胀状态和未膨胀状态，使得护套在膨胀状态和未膨胀状态下保持基本相同的纵向长度。

    Local perfusion device
    8.
    发明申请
    Local perfusion device 有权
    局部灌注装置

    公开(公告)号：US20070060918A1

    公开(公告)日：2007-03-15

    申请号：US11208879

    申请日：2005-08-22

    申请人： Thomas Holman ,  Jan Weber ,  Tracee Eidenschink

    发明人： Thomas Holman ,  Jan Weber ,  Tracee Eidenschink

    IPC分类号： A61B18/18

    CPC分类号： A61F7/12 ,  A61F2007/0063 ,  A61F2007/126

    摘要： A device for providing a fluid to a target tissue region of a body vessel is described. The device includes an elongate member having a lumen to receive a fluid, and a structure deployable from a distal portion of the elongate member to channel blood flowing in the vessel. Also described are a method of, and a system for, providing a fluid to a target tissue region inside a body.

    摘要翻译： 描述了一种用于向身体血管的靶组织区域提供流体的装置。 该装置包括具有用于容纳流体的内腔的细长构件，以及可从细长构件的远侧部分展开以使在血管中流动的血液通道的结构。 还描述了向身体内的靶组织区域提供流体的方法和系统。

    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
    10.
    发明申请
    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 失效

    公开(公告)号：US20060184092A1

    公开(公告)日：2006-08-17

    申请号：US11055930

    申请日：2005-02-11

    申请人： Liliana Atanasoska ,  Thomas Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    发明人： Liliana Atanasoska ,  Thomas Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    IPC分类号： A61N1/30

    CPC分类号： A61N1/325 ,  A61N1/05 ,  A61N1/306 ,  A61N1/327

    摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.