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公开(公告)号：US08563298B2
公开(公告)日：2013-10-22
申请号：US12910594
申请日：2010-10-22
申请人： Thomas Jay Lowery, Jr. , Mark John Audeh , James Franklin Chepin , Rahul Dhanda , Lori Anne Neely , Charles William Rittershaus
发明人： Thomas Jay Lowery, Jr. , Mark John Audeh , James Franklin Chepin , Rahul Dhanda , Lori Anne Neely , Charles William Rittershaus
IPC分类号： C12M1/34 , C12M3/00 , C12Q1/68 , G01N33/53 , C12P19/34 , G01N15/06 , A61B5/055 , G01N24/00 , G01N33/553 , C07H21/04
CPC分类号： G01N27/745 , B82Y25/00 , C12Q1/6825 , C12Q1/6827 , C12Q1/689 , C12Q1/6895 , C12Q1/701 , C12Q2600/156 , G01N24/08 , G01N33/54326 , G01N33/5434 , G01R33/093 , G01R33/1269 , G01R33/281 , G01R33/30 , G01R33/302 , G01R33/448 , Y10T436/24 , C12Q2563/143 , C12Q2565/633
摘要： This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
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公开(公告)号：US20130260367A1
公开(公告)日：2013-10-03
申请号：US13384051
申请日：2011-10-19
申请人： Thomas Jay Lowery, JR. , Mark John Audeh , Matthew Blanco , James Franklin Chepin , Vasiliki Demas , Rahul Dhanda , Marilyn Lee Fritzemeier , Isaac Koh , Sonia Kumar , Lori Anne Neely , Brian Mozeleski , Daniella Lynn Plourde , Charles William Rittershaus , Parris Wellman
发明人： Thomas Jay Lowery, JR. , Mark John Audeh , Matthew Blanco , James Franklin Chepin , Vasiliki Demas , Rahul Dhanda , Marilyn Lee Fritzemeier , Isaac Koh , Sonia Kumar , Lori Anne Neely , Brian Mozeleski , Daniella Lynn Plourde , Charles William Rittershaus , Parris Wellman
IPC分类号： G01N33/543 , C12Q1/70 , G01N33/94 , C12Q1/68
CPC分类号： G01N33/54326 , B82Y25/00 , C12Q1/6825 , C12Q1/6827 , C12Q1/689 , C12Q1/6895 , C12Q1/70 , C12Q1/701 , G01N24/08 , G01N27/745 , G01N33/5434 , G01N33/9493 , G01R33/093 , G01R33/1269 , G01R33/281 , G01R33/302 , G01R33/448 , C12Q2563/143 , C12Q2565/633 , C12Q2563/149 , C12Q2565/113
摘要： This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
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公开(公告)号：US20120100546A1
公开(公告)日：2012-04-26
申请号：US12910594
申请日：2010-10-22
申请人： Thomas Jay Lowery, JR. , Mark John Audeh , Matthew Blanco , James Franklin Chepin , Vasiliki Demas , Rahul Dhanda , Marilyn Lee Fritzemeier , Isaac Koh , Sonia Kumar , Lori Anne Neely , Brian Mozeleski , Daniella Lynn Plourde , Charles William Rittershaus , Parris Wellman
发明人： Thomas Jay Lowery, JR. , Mark John Audeh , Matthew Blanco , James Franklin Chepin , Vasiliki Demas , Rahul Dhanda , Marilyn Lee Fritzemeier , Isaac Koh , Sonia Kumar , Lori Anne Neely , Brian Mozeleski , Daniella Lynn Plourde , Charles William Rittershaus , Parris Wellman
IPC分类号： G01N33/553 , G01R33/30 , C12Q1/68 , G01N27/00 , C12M1/34 , G01N33/566
CPC分类号： G01N27/745 , B82Y25/00 , C12Q1/6825 , C12Q1/6827 , C12Q1/689 , C12Q1/6895 , C12Q1/701 , C12Q2600/156 , G01N24/08 , G01N33/54326 , G01N33/5434 , G01R33/093 , G01R33/1269 , G01R33/281 , G01R33/30 , G01R33/302 , G01R33/448 , Y10T436/24 , C12Q2563/143 , C12Q2565/633
摘要： This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
摘要翻译： 本发明的特征在于用于检测分析物的系统和方法及其在治疗和诊断疾病中的用途。
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公开(公告)号：US20120164644A1
公开(公告)日：2012-06-28
申请号：US13363916
申请日：2012-02-01
申请人： Lori Anne Neely , Mark John Audeh , Matthew Blanco , James Franklin Chepin , Vasiliki Demas , Rahul Dhanda , Thomas Jay Lowery, JR.
发明人： Lori Anne Neely , Mark John Audeh , Matthew Blanco , James Franklin Chepin , Vasiliki Demas , Rahul Dhanda , Thomas Jay Lowery, JR.
IPC分类号： G01N27/72
CPC分类号： G01N27/745 , C12Q1/6816 , C12Q1/6895 , C12Q2537/125 , C12Q2563/143 , C12Q2563/155 , C12Q2565/113 , C12Q2565/633 , C12Q2600/156 , G01N24/08 , G01R33/302 , G01R33/448 , G01R33/465 , Y10T436/24
摘要： This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
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公开(公告)号：US09714940B2
公开(公告)日：2017-07-25
申请号：US13384051
申请日：2011-10-19
申请人： Thomas Jay Lowery, Jr. , Mark John Audeh , Matthew Blanco , James Franklin Chepin , Vasiliki Demas , Rahul Dhanda , Lori Anne Neely
发明人： Thomas Jay Lowery, Jr. , Mark John Audeh , Matthew Blanco , James Franklin Chepin , Vasiliki Demas , Rahul Dhanda , Lori Anne Neely
IPC分类号： G01N33/543 , G01N33/94 , G01N24/08 , G01N27/74 , B82Y25/00 , C12Q1/68 , C12Q1/70 , G01R33/09 , G01R33/12 , G01R33/28 , G01R33/30 , G01R33/44
CPC分类号： G01N33/54326 , B82Y25/00 , C12Q1/6825 , C12Q1/6827 , C12Q1/689 , C12Q1/6895 , C12Q1/70 , C12Q1/701 , G01N24/08 , G01N27/745 , G01N33/5434 , G01N33/9493 , G01R33/093 , G01R33/1269 , G01R33/281 , G01R33/302 , G01R33/448 , C12Q2563/143 , C12Q2565/633 , C12Q2563/149 , C12Q2565/113
摘要： This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
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公开(公告)号：US08409807B2
公开(公告)日：2013-04-02
申请号：US13363916
申请日：2012-02-01
申请人： Lori Anne Neely , Mark John Audeh , Matthew Blanco , James Franklin Chepin , Vasiliki Demas , Rahul K. Dhanda , Thomas Jay Lowery, Jr.
发明人： Lori Anne Neely , Mark John Audeh , Matthew Blanco , James Franklin Chepin , Vasiliki Demas , Rahul K. Dhanda , Thomas Jay Lowery, Jr.
CPC分类号： G01N27/745 , C12Q1/6816 , C12Q1/6895 , C12Q2537/125 , C12Q2563/143 , C12Q2563/155 , C12Q2565/113 , C12Q2565/633 , C12Q2600/156 , G01N24/08 , G01R33/302 , G01R33/448 , G01R33/465 , Y10T436/24
摘要： This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
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公开(公告)号：US20120301888A1
公开(公告)日：2012-11-29
申请号：US13402566
申请日：2012-02-22
申请人： Lori Anne Neely , Mark John Audeh , Rahul Dhanda , Marilyn Lee Fritzemeier , Daniella Lynn Plourde , Charles William Rittershaus
发明人： Lori Anne Neely , Mark John Audeh , Rahul Dhanda , Marilyn Lee Fritzemeier , Daniella Lynn Plourde , Charles William Rittershaus
CPC分类号： G01N27/745 , C12Q1/6816 , C12Q1/6895 , C12Q2537/125 , C12Q2563/143 , C12Q2563/155 , C12Q2565/113 , C12Q2565/633 , C12Q2600/156 , G01N24/08 , G01R33/302 , G01R33/448 , G01R33/465 , Y10T436/24
摘要： This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
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公开(公告)号：US20130196341A1
公开(公告)日：2013-08-01
申请号：US13808347
申请日：2011-07-06
申请人： Lori Anne Neely , Brian M. Mozeleski , Mark John Audeh , Jordan R. Raphel , Thomas Jay Lowery, JR.
发明人： Lori Anne Neely , Brian M. Mozeleski , Mark John Audeh , Jordan R. Raphel , Thomas Jay Lowery, JR.
IPC分类号： G01N33/53
CPC分类号： C12Q1/6834 , G01N33/53 , G01N33/5304 , G01N33/5308 , G01N33/543 , G01N33/54326 , C12Q2537/125 , C12Q2537/149 , C12Q2563/143 , C12Q2563/149 , C12Q2565/113
摘要： Disclosed are methods and compositions for detecting analytes, including proteins, polysaccharides, viruses, nucleic acids and cells. The methods and compositions utilize a reporter probe, suitably a multivalent reporter probe, to detect the presence of the analytes. The methods and compositions can be used for non-enzymatic detection of nucleic acids.
摘要翻译： 公开了用于检测分析物的方法和组合物，包括蛋白质，多糖，病毒，核酸和细胞。 该方法和组合物利用报道探针，合适地是多价报道探针来检测分析物的存在。 方法和组合物可用于核酸的非酶检测。
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公开(公告)号：US09360457B2
公开(公告)日：2016-06-07
申请号：US13402566
申请日：2012-02-22
申请人： Lori Anne Neely , Mark John Audeh , Rahul K. Dhanda , Marilyn Lee Fritzemeier , Daniella Lynn Plourde , Charles William Rittershaus
发明人： Lori Anne Neely , Mark John Audeh , Rahul K. Dhanda , Marilyn Lee Fritzemeier , Daniella Lynn Plourde , Charles William Rittershaus
CPC分类号： G01N27/745 , C12Q1/6816 , C12Q1/6895 , C12Q2537/125 , C12Q2563/143 , C12Q2563/155 , C12Q2565/113 , C12Q2565/633 , C12Q2600/156 , G01N24/08 , G01R33/302 , G01R33/448 , G01R33/465 , Y10T436/24
摘要： This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
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公开(公告)号：US20110275985A1
公开(公告)日：2011-11-10
申请号：US12997817
申请日：2009-07-02
申请人： Thomas Jay Lowery, JR. , James J. Koziarz , Douglas A. Levinson , David A. Berry , Tuan A. Elstrom , Sonia Kumar , Mark John Audeh
发明人： Thomas Jay Lowery, JR. , James J. Koziarz , Douglas A. Levinson , David A. Berry , Tuan A. Elstrom , Sonia Kumar , Mark John Audeh
IPC分类号： A61M5/168 , G01N33/566 , C12Q1/70 , G01N33/53 , G01N24/00 , G01N33/569 , G01N33/68
CPC分类号： G01N24/08 , A61B5/055 , A61B5/14532 , A61B5/14865 , A61B10/0045 , A61B2017/00345 , G01N33/54326 , G01N33/54346 , Y10T436/143333 , Y10T436/144444 , Y10T436/147777 , Y10T436/16 , Y10T436/171538 , Y10T436/175383 , Y10T436/19 , Y10T436/201666 , Y10T436/204998 , Y10T436/207497 , Y10T436/24
摘要： Disclosed are magnetic nanosensors or transducers that permit measurement of a physical parameter in an analyte via magnetic reasonance measurements, in particular of non-agglomerative assays. More particularly, in certain embodiments, the invention relates to designs of nanoparticle reagents and responsive polymer coated magnetic nanoparticles. Additionally provided are methods of use of nanoparticle reagents and responsive polymer coated magnetic nanoparticles for the detection of a stimulus or an analyte with NMR detectors.
摘要翻译： 公开了磁性纳米传感器或换能器，其允许通过磁性推测测量，特别是非聚集测定来测量分析物中的物理参数。 更具体地，在某些实施方案中，本发明涉及纳米颗粒试剂和响应性聚合物包被的磁性纳米颗粒的设计。 另外提供了使用纳米颗粒试剂和响应性聚合物包被的磁性纳米颗粒用于用NMR检测器检测刺激物或分析物的方法。
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