公开(公告)号：US20070224650A1

公开(公告)日：2007-09-27

申请号：US11510366

申请日：2006-08-25

申请人： Thomas Jessell ,  Hynek Wichterle ,  Sara Wilson ,  Ivo Lieberam

发明人： Thomas Jessell ,  Hynek Wichterle ,  Sara Wilson ,  Ivo Lieberam

IPC分类号： G01N33/567 ,  C12N5/06 ,  C12N5/08

CPC分类号： C12N5/0619 ,  A61K35/12 ,  A61K35/545 ,  C12N2501/155 ,  C12N2501/385 ,  C12N2501/41 ,  C12N2501/415 ,  C12N2502/13 ,  C12N2506/02 ,  G01N33/5073 ,  G01N33/74 ,  G01N2333/475 ,  G01N2333/51

摘要： The present invention provides in vitro systems for use in identifying modulators of neural differentiation. Also provided are modulators identified by these systems. The present invention further provides methods for identifying a modulator of neural differentiation, a modulator of an FGF signalling pathway, a modulator of FGF-dependent neural differentiation, a modulator of a retinoid signalling pathway, and a modulator of retinoid-dependent neural differentiation. Also provided are modulators identified by these methods.

摘要翻译： 本发明提供用于鉴定神经分化调节剂的体外系统。 还提供了由这些系统识别的调制器。 本发明还提供用于鉴定神经分化调节剂，FGF信号通路调节剂，FGF依赖性神经分化调节剂，类视黄醇信号通路调节剂和类视黄醇依赖性神经分化调节剂的方法。 还提供了通过这些方法鉴定的调节剂。

公开(公告)号：US20070185024A1

公开(公告)日：2007-08-09

申请号：US11510038

申请日：2006-08-25

申请人： Thomas Jessell ,  Hynek Wichterle ,  Sara Wilson ,  Ivo Lieberam

发明人： Thomas Jessell ,  Hynek Wichterle ,  Sara Wilson ,  Ivo Lieberam

IPC分类号： A61K38/17 ,  G01N33/567 ,  C12N5/08 ,  A61K31/203 ,  A61K31/07

CPC分类号： C12N5/0619 ,  A61K35/12 ,  C12N5/0623 ,  C12N2501/155 ,  C12N2501/385 ,  C12N2501/41 ,  C12N2501/415 ,  C12N2503/00 ,  C12N2503/02 ,  C12N2506/02 ,  G01N33/5073 ,  G01N2333/51 ,  Y02A50/465

摘要： The present invention provides in vitro systems for use in identifying modulators of neural differentiation. Also provided are modulators identified by these systems. The present invention further provides methods for identifying a modulator of neural differentiation, a modulator of a Wnt signalling pathway, a modulator of Wnt-dependent neural differentiation, a modulator of a BMP signalling pathway, a modulator of BMP-dependent neural differentiation, a modulator of a Hh signalling pathway, and a modulator of Hh-dependent neural differentiation. Also provided are modulators identified by these methods.

摘要翻译： 本发明提供用于鉴定神经分化调节剂的体外系统。 还提供了由这些系统识别的调制器。 本发明还提供用于鉴定神经分化调节剂，Wnt信号通路调节剂，Wnt依赖性神经分化调节剂，BMP信号通路调节剂，BMP依赖性神经分化调节剂，调节剂 的Hh信号通路，以及Hh依赖性神经分化的调节剂。 还提供了通过这些方法鉴定的调节剂。

公开(公告)号：US07390659B2

公开(公告)日：2008-06-24

申请号：US10196882

申请日：2002-07-16

申请人： Thomas Jessell ,  Hynek Wichterle ,  Ivo Lieberam

发明人： Thomas Jessell ,  Hynek Wichterle ,  Ivo Lieberam

IPC分类号： C12N5/00 ,  C12N5/02

CPC分类号： C12N5/0619 ,  A61K35/12 ,  C12N2501/385 ,  C12N2501/41 ,  C12N2506/02 ,  Y02A50/465

摘要： The present invention provides a method for inducing differentiation of an embryonic stem cell into a differentiated neural cell. The present invention further provides a method for producing differentiated neural cells, and a population of cells comprising the differentiated neural cells. Additionally, the present invention provides a method for repopulating a spinal cord in a subject, and a method for treating nervous tissue degeneration in a subject in need of treatment. The present invention further provides neural progenitor cells, differentiated neural cells, and uses of same. Also provided is a transgenic non-human animal containing the differentiated neural cells. The present invention is further directed to a method for isolating a population of differentiated neural cells. Finally, the present invention provides a method for identifying an agent for use in treating a condition associated with neuron degeneration.

摘要翻译： 本发明提供了诱导胚胎干细胞分化为分化神经细胞的方法。 本发明还提供了用于产生分化的神经细胞的方法和包含分化的神经细胞的细胞群。 另外，本发明提供了一种用于在受试者中重新填充脊髓的方法，以及用于治疗需要治疗的受试者中的神经组织变性的方法。 本发明还提供神经祖细胞，分化神经细胞及其用途。 还提供了含有分化的神经细胞的转基因非人动物。 本发明还涉及分离分化的神经细胞群体的方法。 最后，本发明提供一种用于鉴定用于治疗与神经元变性相关的病症的药剂的方法。