公开(公告)号：US20100238441A1

公开(公告)日：2010-09-23

申请号：US12682939

申请日：2008-10-13

申请人： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

发明人： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

IPC分类号： G01N21/49 ,  G01N21/00

CPC分类号： G01N21/4795 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  A61B2562/146 ,  G01N2021/1787 ,  G01N2201/0826 ,  G01N2201/0833

摘要： A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.

摘要翻译： 提供了用于对光学混浊介质的内部成像的装置（1）。 该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。 所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。 光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。 联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接 所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。

公开(公告)号：US09488574B2

公开(公告)日：2016-11-08

申请号：US12682939

申请日：2008-10-13

申请人： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

发明人： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

IPC分类号： G01N21/47 ,  A61B5/00 ,  G01N21/17

CPC分类号： G01N21/4795 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  A61B2562/146 ,  G01N2021/1787 ,  G01N2201/0826 ,  G01N2201/0833

摘要： A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.

摘要翻译： 提供了用于对光学混浊介质的内部成像的装置（1）。 该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。 所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。 光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。 联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接 所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。

公开(公告)号：US20100030084A1

公开(公告)日：2010-02-04

申请号：US12514589

申请日：2007-11-12

申请人： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

发明人： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

IPC分类号： A61B6/00 ,  G06K9/00

CPC分类号： A61B5/4312 ,  A61B5/0091 ,  G01N21/4795 ,  G01N21/6456

摘要： The invention relates to a system, a medical image acquisition system, and a method for imaging an interior of a turbid medium (25). The invention also relates to a marker (60) for use in the method for imaging an interior of a turbid medium (25). The system, the medical image acquisition system, and the method may be used for obtaining an image of an interior of a turbid medium (25) by: accommodation of a turbid medium (25) inside a receiving volume (20); irradiation of the receiving volume (20) with light from a light source; detection of light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with light from the light source through the use of a photodetector unit. The detected light is then used to reconstruct an image of an interior of the turbid medium (25). According to the invention, the system, the medical acquisition system, and the method are adapted such that during a measurement the receiving volume (20) comprises at least one marker (60) comprising a predetermined concentration of a chosen fluorescent agent. The light source is arranged for generating excitation light that causes fluorescent emission in the marker (60) and the photodetector is arranged to detect light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with excitation light. The use of a marker (60) according to the invention enables obtaining information relating to the geometry of the turbid medium (25). If the turbid medium (25) comprises an unknown concentration of a second fluorescent agent, and the light source and the photodetector unit are arranged for causing fluorescence in the second fluorescent agent and detecting the resulting fluorescence light, respectively, the use of a marker (60) according to the invention enables calibration of the signal resulting from this fluorescence light.

公开(公告)号：US20080309941A1

公开(公告)日：2008-12-18

申请号：US12094802

申请日：2006-11-20

申请人： Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

发明人： Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

IPC分类号： G01N21/00

CPC分类号： G01N21/4795 ,  G01N2021/1787 ,  G01N2021/4766 ,  G01N2021/6439

摘要： The invention relates to a method of imaging an interior of a turbid medium (45) comprising the following steps: accommodation of the turbid medium (45) inside a receiving volume; coupling transmission input light (65) from a transmission light source into the receiving volume, with said transmission input light (65) being chosen such that it is capable of propagating through the turbid medium (45); detection of transmission output light emanating from the receiving volume as a result of coupling transmission input light from the light source into the receiving volume through use of a transmission photodetector unit. The invention also relates to a system for imaging an interior of a turbid medium (45) and to a medical image acquisition system both using the method. The method, system, and medical image acquisition system are adapted such that an improved way of obtaining data relating to the exterior of the turbid medium (45) is realized. The object of the invention is realized in that the method further comprises the following steps:—coupling geometry input light (70, 75, 80) from a geometry light source into the receiving volume, with the receiving volume comprising the turbid medium (45) and with the combination of the geometry input light (70, 75, 80) and the interface (60) being chosen for creating a contrast between the turbid medium (45) and its surroundings; detection of the contrast (60) between the turbid medium (45) and its surroundings through use of a contrast photodetector unit; reconstructing an image of an interior of the turbid medium (45) using a the detected contrast (60). The system for imaging an interior of a turbid medium (45) and the medical image acquisition device are adapted to further comprise a geometry light source and a contrast photodetector unit.

公开(公告)号：US08355131B2

公开(公告)日：2013-01-15

申请号：US12525748

申请日：2008-01-29

申请人： Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

发明人： Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

IPC分类号： G01N21/55 ,  G01N21/00 ,  A61B5/00 ,  A61B6/00

CPC分类号： G01N21/4795 ,  A61B5/0091 ,  A61B5/4312

摘要： A device and method of acquiring image data from a turbid medium using a diffuse optical tomography device including irradiating the turbid medium at a plurality of first spatial positions, collecting light emanating from the turbid medium at a plurality of second spatial positions, splitting the light collected from each second spatial position into at least two optical channels, measuring the intensity of the split light in each optical channel of the at least two optical channels using photo detectors, and reconstructing an image of the turbid medium from the measured intensities.

摘要翻译： 一种使用扩散光学断层摄影装置从混浊介质获取图像数据的装置和方法，包括在多个第一空间位置照射混浊介质，在多个第二空间位置收集从混浊介质发出的光，将收集到的光分开 从每个第二空间位置到至少两个光学通道，使用光电检测器测量所述至少两个光学通道的每个光学通道中的分裂光的强度，以及根据测量的强度重建所述混浊介质的图像。

公开(公告)号：US20100262018A1

公开(公告)日：2010-10-14

申请号：US12740145

申请日：2008-10-28

申请人： Levinus Pieter Bakker ,  Bernhard J. Brendel ,  Rik Harbers ,  Martinus Bernardus Van Der Mark

发明人： Levinus Pieter Bakker ,  Bernhard J. Brendel ,  Rik Harbers ,  Martinus Bernardus Van Der Mark

IPC分类号： A61B6/00

CPC分类号： G01N21/4795 ,  A61B5/0091 ,  A61B5/4312 ,  G01N21/15 ,  G01N2021/1787 ,  G01N2021/4719 ,  G01N2201/0826 ,  G01N2201/0833

摘要： A method of controlling a device for imaging the interior of turbid media is provided. The device comprises: a receiving portion (2) for receiving a turbid medium (1) to be examined; at least one light source (6) optically connected to the receiving portion (2) for irradiating the interior of the receiving portion (2); and at least one detector (7) optically connected to the receiving portion (2) for detecting light emanating from the interior of the receiving portion (2). The at least one light source (6) and the at least one detector (7) areoptically connected to the receiving portion (2) such that a plurality of different source-detector position combinations are formed over a complete measurement. The different source-detector position combinations define different light paths through the receiving portion (2). The method comprises a fast-measurement step in which a reduced set of data corresponding to only a part of the plurality of source-detector position combinations is generated for providing fast-information about the interior of the receiving portion (2).

摘要翻译： 提供了一种控制用于对浑浊介质内部进行成像的装置的方法。 该装置包括：接收部分（2），用于接收待检查的混浊介质（1）; 至少一个光源（6），其光学连接到所述接收部分（2）以照射所述接收部分（2）的内部; 以及光学连接到所述接收部分（2）的至少一个检测器（7），用于检测从所述接收部分（2）的内部发出的光。 所述至少一个光源（6）和所述至少一个检测器（7）光学地连接到所述接收部分（2），使得在完整测量上形成多个不同的源 - 检测器位置组合。 不同的源 - 检测器位置组合限定穿过接收部分（2）的不同光路。 该方法包括快速测量步骤，其中生成仅对应于多个源 - 检测器位置组合的一部分的减少的数据集合，用于提供关于接收部分（2）的内部的快速信息。

公开(公告)号：US07750331B2

公开(公告)日：2010-07-06

申请号：US12094634

申请日：2006-11-21

申请人： Levinus Pieter Bakker ,  Gert 'T Hooft ,  Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek

发明人： Levinus Pieter Bakker ,  Gert 'T Hooft ,  Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek

IPC分类号： G01N15/06 ,  G01N21/49 ,  G01N21/85

CPC分类号： A61B5/4312 ,  A61B5/0091

摘要： The invention relates to a method and device (1) for imaging an interior of a turbid medium (55). A turbid medium (55) inside a measurement volume (15) is irradiated from a plurality of source positions (25a) with light from a light source (5), and light emanating from the measurement volume (15) is detected from a plurality of detection positions (25b). An image of the interior of the turbid medium (55) is reconstructed from the detected light. In both the method and the device (1), detector signals can be amplified for each source position-detection position pair by a multi-gain amplification unit comprising an amplifier circuit (60). The amplification factor is selected from a number of possible amplification factors based on detected signal strength in the prior art. According to the invention, however, the method and device are adapted such that the amplification factor is selected for at least one source position-detection position pair on the basis of an estimate of expected electrical signal strength.

摘要翻译： 本发明涉及一种用于对浑浊介质（55）的内部进行成像的方法和装置（1）。 从多个源位置（25a）利用来自光源（5）的光照射测量体积（15）内部的混浊介质（55），并且从测量体积（15）发出的光从多个 检测位置（25b）。 从检测到的光重建混浊介质（55）的内部的图像。 在方法和装置（1）中，通过包括放大器电路（60）的多增益放大单元，可以为每个源位置检测位置对放大检测器信号。 基于现有技术中检测到的信号强度，从多个可能的放大因子中选择放大因子。 然而，根据本发明，所述方法和装置被适配成使得根据预期的电信号强度的估计为至少一个源位置检测位置对选择放大系数。

公开(公告)号：US20100030067A1

公开(公告)日：2010-02-04

申请号：US12515297

申请日：2007-11-14

申请人： Michael Cornelis Van Beek ,  Martinus Bernardus Van Der Mark ,  Levinus Pieter Bakker ,  Rene Van Den Ham ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Ralf Hoffmann ,  Nijs Cornelis Van Der Vaart ,  Marjolein Van Der Voort

发明人： Michael Cornelis Van Beek ,  Martinus Bernardus Van Der Mark ,  Levinus Pieter Bakker ,  Rene Van Den Ham ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Ralf Hoffmann ,  Nijs Cornelis Van Der Vaart ,  Marjolein Van Der Voort

IPC分类号： A61B5/05 ,  A61B8/14

CPC分类号： A61B5/4381 ,  A61B5/0073 ,  A61B5/0084 ,  A61B5/0086 ,  A61B8/12

摘要： A system for imaging of prostate cancer in a prostate in vivo is provided. The system utilizes Diffuse Optical Tomography (DOT) for creating a 3D image for the detection of suspicious prostate tissue. The DOT image may be used to guide the biopsy, thereby reducing the number of false negatives. A method, computer-readable medium and use are also provided.

摘要翻译： 提供了一种用于前列腺体内前列腺癌成像的系统。 该系统利用漫射光学层析成像（DOT）创建用于检测可疑前列腺组织的3D图像。 DOT图像可用于指导活组织检查，从而减少假阴性的数量。 还提供了一种方法，计算机可读介质和使用。

公开(公告)号：US20100027018A1

公开(公告)日：2010-02-04

申请号：US12525748

申请日：2008-01-29

申请人： Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

发明人： Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

IPC分类号： G01N21/47

CPC分类号： G01N21/4795 ,  A61B5/0091 ,  A61B5/4312

摘要： The invention relates to a method of acquiring image data from a turbid medium (102) using a diffuse optical tomography device, comprising: —irradiating the turbid medium (102) at a plurality of first spatial positions (106), —collecting light emanating from the turbid medium (102) at a plurality of 5 second spatial positions (136), —splitting the light collected from each second spatial position (136) into at least two optical channels (140), —measuring the intensity of the split light in each optical channel of the at least two optical channels (140) using photo detectors (142),10 —reconstructing (152) an image of the turbid medium (102) from the measured intensities.

摘要翻译： 本发明涉及一种使用漫射光学断层摄影装置从混浊介质（102）获取图像数据的方法，包括：在多个第一空间位置（106）处照射浑浊介质（102）， - 收集来自 在多个5秒空间位置（136）处的混浊介质（102），将从每个第二空间位置（136）收集的光分成至少两个光学通道（140）， - 测量分离光的强度 使用光电检测器（142）至少两个光学通道（140）的每个光学通道，根据测量的强度重新构造（152）浑浊介质（102）的图像。

公开(公告)号：US20080309940A1

公开(公告)日：2008-12-18

申请号：US12094698

申请日：2006-11-20

申请人： Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

发明人： Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

IPC分类号： G01N21/00

CPC分类号： G01N21/4795 ,  G01N2021/1787 ,  G01N2021/4766 ,  G01N2021/6439

摘要： The invention relates to a method of imaging an interior of a turbid medium (45) comprising the following steps: accommodation of the turbid medium (45) inside a receiving volume (20); coupling transmission input light (65) from a transmission light source into the receiving volume (12), with said transmission input light (65) being chosen such that it is capable of propagating through the turbid medium (45) and with at least a part of said transmission input light (65) passing through a matching medium (50) in the receiving volume (12), said matching medium (50) being chosen to reduce optical boundary effects at an interface between the turbid medium (45) and its surroundings; detection of transmission output light emanating from the receiving volume as a result of coupling transmission input light (65) from the transmission light source into the receiving volume (12) through use of a transmission photodetector unit. The invention also relates to a system for imaging an interior of a turbid medium (45) and a medical image acquisition system both using the method. According to the invention, the method, system for imaging an interior of a turbid medium (45), and medical image acquisition system are adapted such that data relating to the exterior of the turbid medium (45) can be obtained. This object is realized in that the method further comprises the following additional steps: coupling geometry input light (70, 75, 80) from a geometry light source into the receiving volume (12), with the receiving volume comprising the turbid medium (45), with the receiving volume (12) further comprising a geometry medium (60) for surrounding the turbid medium (45) during coupling of geometry input light (70, 75, 80) into the receiving volume (12), and with the combination of the geometry input light (70, 75, 80), the geometry medium (60), and the interface being chosen for creating a contrast between the turbid medium and its surroundings; —detection of the contrast between the turbid medium (45) and its surroundings; reconstructing an image of an interior of the turbid medium (45) using the detected contrast.