公开(公告)号：US20100030084A1

公开(公告)日：2010-02-04

申请号：US12514589

申请日：2007-11-12

申请人： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

发明人： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

IPC分类号： A61B6/00 ,  G06K9/00

CPC分类号： A61B5/4312 ,  A61B5/0091 ,  G01N21/4795 ,  G01N21/6456

摘要： The invention relates to a system, a medical image acquisition system, and a method for imaging an interior of a turbid medium (25). The invention also relates to a marker (60) for use in the method for imaging an interior of a turbid medium (25). The system, the medical image acquisition system, and the method may be used for obtaining an image of an interior of a turbid medium (25) by: accommodation of a turbid medium (25) inside a receiving volume (20); irradiation of the receiving volume (20) with light from a light source; detection of light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with light from the light source through the use of a photodetector unit. The detected light is then used to reconstruct an image of an interior of the turbid medium (25). According to the invention, the system, the medical acquisition system, and the method are adapted such that during a measurement the receiving volume (20) comprises at least one marker (60) comprising a predetermined concentration of a chosen fluorescent agent. The light source is arranged for generating excitation light that causes fluorescent emission in the marker (60) and the photodetector is arranged to detect light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with excitation light. The use of a marker (60) according to the invention enables obtaining information relating to the geometry of the turbid medium (25). If the turbid medium (25) comprises an unknown concentration of a second fluorescent agent, and the light source and the photodetector unit are arranged for causing fluorescence in the second fluorescent agent and detecting the resulting fluorescence light, respectively, the use of a marker (60) according to the invention enables calibration of the signal resulting from this fluorescence light.

公开(公告)号：US20100238441A1

公开(公告)日：2010-09-23

申请号：US12682939

申请日：2008-10-13

申请人： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

发明人： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

IPC分类号： G01N21/49 ,  G01N21/00

CPC分类号： G01N21/4795 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  A61B2562/146 ,  G01N2021/1787 ,  G01N2201/0826 ,  G01N2201/0833

摘要： A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.

摘要翻译： 提供了用于对光学混浊介质的内部成像的装置（1）。 该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。 所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。 光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。 联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接 所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。

公开(公告)号：US09488574B2

公开(公告)日：2016-11-08

申请号：US12682939

申请日：2008-10-13

申请人： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

发明人： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

IPC分类号： G01N21/47 ,  A61B5/00 ,  G01N21/17

CPC分类号： G01N21/4795 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  A61B2562/146 ,  G01N2021/1787 ,  G01N2201/0826 ,  G01N2201/0833

摘要： A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.

摘要翻译： 提供了用于对光学混浊介质的内部成像的装置（1）。 该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。 所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。 光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。 联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接 所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。

公开(公告)号：US20090259130A1

公开(公告)日：2009-10-15

申请号：US12439726

申请日：2007-09-05

申请人： Martinus Bernardus Van Der Mark ,  Willem Peter Van Der Brug ,  Tim Nielsen

发明人： Martinus Bernardus Van Der Mark ,  Willem Peter Van Der Brug ,  Tim Nielsen

IPC分类号： A61B6/00

CPC分类号： A61B5/415 ,  A61B5/0091 ,  A61B5/418 ,  A61B5/4312

摘要： The invention relates to a device for imaging an interior of a turbid medium comprising: a) a receiving volume for receiving at least a part of the turbid medium, with the receiving volume being bound by a boundary having an opening bound by a brim, b) a light source for irradiating the turbid medium, and c) a photodetector unit for detecting light emanating from the volume as a result of irradiating the turbid medium. The device is adapted such that the brim is arranged for optically coupling the light source to the turbid medium and the turbid medium to the photodetector unit. One embodiment of the invention relates to a device for imaging an interior of a female breast comprising a cup-like receptacle (20) for accommodating the breast. The receptacle (20) comprises a convex shaped brim (60) arranged for optically coupling the light source to the patient's (55) breast and the breast to the photodetector unit.

摘要翻译： 本发明涉及一种用于对浑浊介质内部进行成像的装置，包括：a）用于接收混浊介质的至少一部分的接收体积，其中接收体积被具有边缘边界的边界限制，b ）用于照射混浊介质的光源，以及c）用于通过照射混浊介质来检测从体积发出的光的光电检测器单元。 该装置适于使得边缘布置成将光源光学耦合到混浊介质和混浊介质到光电探测器单元。 本发明的一个实施例涉及一种用于对女性乳房内部进行成像的装置，其包括用于容纳乳房的杯状容器（20）。 插座（20）包括凸形的边缘（60），该凸缘布置用于将光源光学地耦合到患者的（55）乳房和乳房到光电检测器单元。

公开(公告)号：US07672424B2

公开(公告)日：2010-03-02

申请号：US11575902

申请日：2005-09-22

申请人： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Roland Proksa ,  Dominic J. Heuscher

发明人： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Roland Proksa ,  Dominic J. Heuscher

IPC分类号： A61B6/00

CPC分类号： G06T11/006

摘要： A radiographic imaging apparatus includes a radiation detector (16) and a radiation source (12) which projects a non-parallel beam of radiation into field of view (14). A footprint of each voxel (v) which is projected on the detector (16) is corrected based on the position of the voxel (v) in the field of view (14) in relation to the radiation detector (16) and the radiation source (12). The contributions from substantially parallel redundant projections are further combined based on a fractional distance frac from a center point (82) of the voxel (v) to a center of each of the adjacent redundant projections.

摘要翻译： 放射线照相成像装置包括辐射检测器（16）和辐射源（12），其将非平行辐射束投射到视场（14）中。 基于在视场（14）中相对于放射线检测器（16）的体素（v）的位置和辐射源（v）来校正投影在检测器（16）上的每个体素（v）的足迹 （12）。 基于从体素（v）的中心点（82）到每个相邻冗余投影的中心的分数距离压裂进一步组合基本上平行的冗余投影的贡献。

公开(公告)号：US20080273655A1

公开(公告)日：2008-11-06

申请号：US11570896

申请日：2005-06-24

申请人： Tim Nielsen ,  Andy Ziegler ,  Thomas Koehler ,  Roland Proksa

发明人： Tim Nielsen ,  Andy Ziegler ,  Thomas Koehler ,  Roland Proksa

IPC分类号： A61B6/00 ,  G06K9/00

CPC分类号： G06T11/006 ,  A61B6/027 ,  G06T2211/421 ,  Y10S378/901

摘要： The invention relates to an imaging method, especially a computerized tomography method, with which an object is penetrated by rays from different directions and measured values, which depend upon the intensity of the rays after penetrating the object, are acquired by a detector unit. From these measured values, an object image is reconstructed by means of back projection of measured-value-dependent back projection values. Therein, the object image is divided into overlapping, quasi-spherically symmetric image segments, each being defined by an image value and a quasi-spherically symmetric base function. Furthermore, during the back projection, the back projection values are added in proportions to the image values, wherein the proportion of a back projection value, which is added during the back projection to an image value, is dependent on a proportionality factor, which is equal to the average value of the line integrals of the base function belonging to the respective image value along those rays that have generated the measured value, on which the respective back projection value is dependent.

摘要翻译： 本发明涉及一种成像方法，特别是计算机断层摄影方法，其中物体被来自不同方向的光线穿透，并且测量值取决于穿透物体之后的光线的强度，由检测器单元获取。 从这些测量值，通过背投影测量值依赖的反投影值重建对象图像。 其中，对象图像被划分为重叠的准球形对称图像片段，每个片段由图像值和准球形对称的基本功能定义。 此外，在背投影期间，反投影值以与图像值成比例的方式相加，其中在后投影中添加的反投影值与图像值的比例取决于比例因子，即比例因子 等于属于相应图像值的基本功能的线积分的平均值，沿着相应的背投影值依赖于已经产生测量值的那些射线。

公开(公告)号：US20090202036A1

公开(公告)日：2009-08-13

申请号：US11575902

申请日：2005-09-22

申请人： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Roland Proksa ,  Dominic J, Heuscher

发明人： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Roland Proksa ,  Dominic J, Heuscher

IPC分类号： H05G1/60 ,  G06K9/00

CPC分类号： G06T11/006

摘要： A radiographic imaging apparatus includes a radiation detector (16) and a radiation source (12) which projects a non-parallel beam of radiation into field of view (14). A footprint of each voxel (v) which is projected on the detector (16) is corrected based on the position of the voxel (v) in the field of view (14) in relation to the radiation detector (16) and the radiation source (12). The contributions from substantially parallel redundant projections are further combined based on a fractional distance frac from a center point (82) of the voxel (v) to a center of each of the adjacent redundant projections.

摘要翻译： 放射线照相成像装置包括辐射检测器（16）和辐射源（12），其将非平行辐射束投射到视场（14）中。 基于在视场（14）中相对于放射线检测器（16）的体素（v）的位置和辐射源（v）来校正投影在检测器（16）上的每个体素（v）的足迹 （12）。 基于从体素（v）的中心点（82）到每个相邻冗余投影的中心的分数距离压裂进一步组合基本上平行的冗余投影的贡献。

公开(公告)号：US07570731B2

公开(公告)日：2009-08-04

申请号：US11570896

申请日：2005-06-24

申请人： Tim Nielsen ,  Andy Ziegler ,  Thomas Koehler ,  Roland Proksa

发明人： Tim Nielsen ,  Andy Ziegler ,  Thomas Koehler ,  Roland Proksa

IPC分类号： A61B6/03

CPC分类号： G06T11/006 ,  A61B6/027 ,  G06T2211/421 ,  Y10S378/901

摘要： The invention relates to an imaging method, especially a computerized tomography method, with which an object is penetrated by rays from different directions and measured values, which depend upon the intensity of the rays after penetrating the object, are acquired by a detector unit. From these measured values, an object image is reconstructed by means of back projection of measured-value-dependent back projection values. Therein, the object image is divided into overlapping, quasi-spherically symmetric image segments, each being defined by an image value and a quasi-spherically symmetric base function. Furthermore, during the back projection, the back projection values are added in proportions to the image values, wherein the proportion of a back projection value, which is added during the back projection to an image value, is dependent on a proportionality factor, which is equal to the average value of the line integrals of the base function belonging to the respective image value along those rays that have generated the measured value, on which the respective back projection value is dependent.

摘要翻译： 本发明涉及一种成像方法，特别是计算机断层摄影方法，其中物体被来自不同方向的光线穿透，并且测量值取决于穿透物体之后的光线的强度，由检测器单元获取。 从这些测量值，通过背投影测量值依赖的反投影值重建对象图像。 其中，对象图像被划分为重叠的准球形对称图像片段，每个片段由图像值和准球形对称的基本功能定义。 此外，在背投影期间，反投影值以与图像值成比例的方式相加，其中在后投影中添加的反投影值与图像值的比例取决于比例因子，即比例因子 等于属于相应图像值的基本功能的线积分的平均值，沿着相应的背投影值依赖于已经产生测量值的那些射线。

公开(公告)号：US20100272331A1

公开(公告)日：2010-10-28

申请号：US12747177

申请日：2008-12-10

申请人： Bernhard Johannes Brendel ,  Tim Nielsen ,  Levinus Pieter Bakker ,  Henricus Wilhelm Peter Van Der Heijden

发明人： Bernhard Johannes Brendel ,  Tim Nielsen ,  Levinus Pieter Bakker ,  Henricus Wilhelm Peter Van Der Heijden

IPC分类号： G06T7/00

CPC分类号： A61B5/4312 ,  A61B5/0091

摘要： A method for assessing measurement quality in acquisition of an image of the interior of a medium (1) is provided. The method comprises the steps: subsequently irradiating the medium (1) with light from a plurality of different source positions (s) and, for each source position, detecting light emanating from the medium in a plurality of different detection positions (d) for acquisition of an image of the interior of the medium (1). The method further comprises the step: providing information about whether the measurement quality is deteriorated by exploiting signal symmetry under reversal of the light path.

摘要翻译： 提供了一种评估介质内部图像的测量质量的方法（1）。 该方法包括以下步骤：随后对来自多个不同源位置的光照射介质（1），并且对于每个源位置，在多个不同检测位置（d）中检测从介质发出的光以进行采集 介质（1）的内部的图像。 该方法还包括以下步骤：通过在光路反转下利用信号对称来提供关于测量质量是否劣化的信息。

公开(公告)号：US08520921B2

公开(公告)日：2013-08-27

申请号：US12933887

申请日：2009-03-20

申请人： Ronny Ziegler ,  Andy Ziegler ,  Tim Nielsen

发明人： Ronny Ziegler ,  Andy Ziegler ,  Tim Nielsen

IPC分类号： G06K9/00

CPC分类号： A61B5/4312 ,  A61B5/0091 ,  G01N21/4795 ,  G01N21/6428

摘要： A method for reconstructing a fluorescence image of the interior of a turbid medium is provided. The method comprises the step: accommodating a turbid medium (1) to which a fluorescent contrast agent has been administered in a measurement volume (4). The fluorescent contrast agent is capable of emitting light in a first range of wavelengths upon irradiation with light. The method further comprises: performing attenuation measurements at a plurality of different wavelengths (λi, . . . , λk) by subsequently irradiating the turbid medium (1) with light from a plurality of different source positions and detecting light emanating from the turbid medium (1) in a plurality of detection positions for each source position; reconstructing absorption properties (μa(r, λ) as a function of the position in the interior of the turbid medium (1) for the plurality of different wavelengths from the attenuation measurements; calculating absorption properties as a function of the position in the interior of the turbid medium (1) for wavelengths of the first range of wavelengths; performing a fluorescence measurement by subsequently irradiating the turbid medium (1) with light causing the fluorescent contrast agent to emit light in the first range of wavelengths from the plurality of source positions and detecting the light emanating from the fluorescent contrast agent in the plurality of detection positions for each source position; and reconstructing a fluorescence image of the spatial distribution of the fluorescent contrast agent in the interior of the turbid medium (1) from the fluorescence measurement using the calculated absorption properties.

摘要翻译： 提供了一种用于重建浑浊介质内部的荧光图像的方法。 该方法包括以下步骤：在测量体积（4）中容纳已投与荧光造影剂的混浊介质（1）。 荧光造影剂能够在照射光时在第一波长范围内发光。 该方法还包括：通过随后用来自多个不同源位置的光照射浑浊介质（1）并检测从浑浊介质发出的光，以多个不同波长（兰德，兰布克）进行衰减测量 1）在每个源位置的多个检测位置; 根据衰减测量重建吸收性质（mu（r，λ））作为多个不同波长的混浊介质（1）内部的位置的函数;计算作为内部位置的函数的吸收特性 用于波长第一波长范围的混浊介质（1）;通过随后用引起荧光对比剂的光在多个源位置发射第一波长范围内的光来照射浑浊介质来进行荧光测量 以及在每个源位置的多个检测位置中检测从荧光对比剂发出的光;以及从所述荧光测量中使用所述荧光测量重建所述浑浊介质（1）内的荧光对比剂的空间分布的荧光图像，使用 计算吸收性能。