公开(公告)号：US20080109374A1

公开(公告)日：2008-05-08

申请号：US11971361

申请日：2008-01-09

申请人： Thomas Levergood ,  Lawrence Stewart ,  Stephen Morris ,  Andrew Payne ,  George Treese

发明人： Thomas Levergood ,  Lawrence Stewart ,  Stephen Morris ,  Andrew Payne ,  George Treese

IPC分类号： G06Q40/00 ,  G06Q30/00

CPC分类号： H04L63/0807 ,  G06Q20/10 ,  G06Q20/102 ,  G06Q20/401 ,  G06Q30/02 ,  G06Q30/0209 ,  G06Q30/06 ,  G06Q30/0601 ,  H04L63/083

摘要： This invention relates to methods for controlling and monitoring access to network servers. In particular, the process described in the invention includes client-server sessions over the Internet. In this environment, when the user attempts to access an access-controlled file, the server subjects the request to a secondary server which determines whether the client has an authorization or valid account. Upon such verification, the user is provided with a session identification which allows the user to access to the requested file as well as any other files within the present protection domain.

摘要翻译： 本发明涉及用于控制和监视对网络服务器的访问的方法。 特别地，本发明中描述的过程包括通过因特网的客户端 - 服务器会话。 在这种环境中，当用户尝试访问访问控制的文件时，服务器将请求发送到辅助服务器，从而确定客户端是否具有授权或有效的帐户。 在这样的验证之后，向用户提供允许用户访问所请求的文件以及当前保护域内的任何其他文件的会话标识。

公开(公告)号：US20060095526A1

公开(公告)日：2006-05-04

申请号：US11300245

申请日：2005-12-13

申请人： Thomas Levergood ,  Lawrence Stewart ,  Stephen Morris ,  Andrew Payne ,  George Treese

发明人： Thomas Levergood ,  Lawrence Stewart ,  Stephen Morris ,  Andrew Payne ,  George Treese

IPC分类号： G06F15/16

CPC分类号： H04L63/0807 ,  G06Q20/10 ,  G06Q20/102 ,  G06Q20/401 ,  G06Q30/02 ,  G06Q30/0209 ,  G06Q30/06 ,  G06Q30/0601 ,  H04L63/083

摘要： This invention relates to methods for controlling and monitoring access to network servers. In particular, the process described in the invention includes client-server sessions over the Internet. In this environment, when the user attempts to access an access-controlled file, the server subjects the request to a secondary server which determines whether the client has an authorization or valid account. Upon such verification, the user is provided with a session identification which allows the user to access to the requested file as well as any other files within the present protection domain.

摘要翻译： 本发明涉及用于控制和监视对网络服务器的访问的方法。 特别地，本发明中描述的过程包括通过因特网的客户端 - 服务器会话。 在这种环境中，当用户尝试访问访问控制的文件时，服务器将请求发送到辅助服务器，从而确定客户端是否具有授权或有效的帐户。 在这样的验证之后，向用户提供允许用户访问所请求的文件以及当前保护域内的任何其他文件的会话标识。

公开(公告)号：US08573602B2

公开(公告)日：2013-11-05

申请号：US13215528

申请日：2011-08-23

申请人： Andrew Payne ,  Brent R. Sedlar ,  David M. Toth ,  Frederick R. Hatch

发明人： Andrew Payne ,  Brent R. Sedlar ,  David M. Toth ,  Frederick R. Hatch

IPC分类号： F16J15/32

CPC分类号： F16J15/3224 ,  F16J15/3244

摘要： A radial shaft seal configured for receipt in a housing and about a shaft to sealingly isolate an air-side of the shaft seal from an oil-side of the shaft seal is provided. The seal includes an annular mounting portion and a seal lip operably attached to the mounting portion. The seal lip has an annular inner sealing surface extending axially between an oil-side end and a free air-side end. The inner sealing surface has a first groove region extending along the shaft in sealed engagement therewith and a second groove region extending along the shaft in sealed engagement therewith. The first groove region and the second groove region are spaced axially from one another by an intermediate non-grooved region. The first groove region is configured to direct contamination toward the air-side of the seal and the second groove region is configured to direct lubrication toward the oil-side of the seal.

摘要翻译： 提供了一种径向轴密封件，其构造成用于容纳在壳体中并且围绕轴，以将轴封的空气侧与轴封的油侧密封隔离。 密封件包括可操作地附接到安装部分的环形安装部分和密封唇缘。 密封唇缘具有在油侧端部和自由空气侧端部之间轴向延伸的环形内部密封表面。 内部密封表面具有沿着轴与密封接合的第一槽区域和沿着轴密封接合的第二槽区域。 第一凹槽区域和第二凹槽区域通过中间非凹槽区域彼此轴向隔开。 第一槽区域构造成将污染物引导到密封件的空气侧，并且第二槽区域构造成朝向密封件的油侧引导润滑。

公开(公告)号：US20070259347A1

公开(公告)日：2007-11-08

申请号：US11417353

申请日：2006-05-03

申请人： David B. Gordon ,  Andrew Payne

发明人： David B. Gordon ,  Andrew Payne

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12M3/00

CPC分类号： C07H21/04 ,  C12Q1/6837 ,  C12Q2565/507 ,  C12Q2525/197

摘要： Methods and articles for analyzing nucleotide sequences of nucleic acid molecules, e.g., using multiple probes per spot of an array, are described. In some embodiments, the methods and articles can reduce the numbers of arrays necessary to probe regions of interest in a biological sample, and/or increase the resolution at which biological events are probed. In some cases, these methods exploit the vertical aspect of an array in order to decrease the number of arrays or spots required for an assay. These probes may be in the form of compound probes, which comprise at least first and second probes, including first and second nucleotide sequences capable of hybridizing to first and second target nucleotide sequences, respectively, in a nucleic acid molecule of interest.

摘要翻译： 描述了分析核酸分子的核苷酸序列的方法和制品，例如每阵列阵列使用多个探针。 在一些实施方案中，所述方法和制品可以减少探测生物样品中感兴趣区域所需的阵列数量和/或增加探测生物学事件的分辨率。 在某些情况下，这些方法利用阵列的垂直方面，以减少测定所需的阵列数或点数。 这些探针可以是化合物探针的形式，其包含至少第一和第二探针，包括分别在目的核酸分子中能够与第一和第二靶核苷酸序列杂交的第一和第二核苷酸序列。

公开(公告)号：US20050245507A1

公开(公告)日：2005-11-03

申请号：US10516065

申请日：2003-05-28

申请人： Ian Forbes ,  Andrew Gribble ,  Andrew Lightfoot ,  Andrew Payne ,  Graham Walker

发明人： Ian Forbes ,  Andrew Gribble ,  Andrew Lightfoot ,  Andrew Payne ,  Graham Walker

IPC分类号： A61K31/55 ,  A61P1/08 ,  A61P3/04 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  C07D209/44 ,  C07D217/02 ,  C07D217/04 ,  C07D223/16

CPC分类号： C07D223/16 ,  C07D209/44 ,  C07D217/02 ,  C07D217/04

摘要： The invention provides compounds of formula (I): wherein A and B represent the groups —(CH2)m— and —(CH2)n— respectively; R1 represents hydrogen or C1-6alkyl; R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pOC3-6cycloalkyl, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR5R6, —SO2NR5R6, —(CH2)pNR5R6, —(CH2)pNR5COR6, optionally substituted aryl ring, optionally substituted heteroaryl ring or optionally substituted heterocyclyl ring; R3 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pOC3-6cycloalkyl, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR7R8, —SO2NR7R8, —(CH2)pNR7R8 or —(CH2)pNR7COR8; R4 represents hydrogen, hydroxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, trifluoromethyl, trifluoromethoxy, halogen, —OSO2CF3, —(CH2)pC3-6cycloalkyl, —(CH2)qOC1-6alkyl or —(CH2)pOC3-6cycloalkyl; R5 and R6 each independently represent hydrogen, C1-6alkyl or, together with the nitrogen or other atoms to which they are attached, form an azacycloalkyl ring or an oxo-substituted azacycloalkyl ring; R7 and R8 each independently represent hydrogen or C1-6alkyl; m and n independently represent an integer selected from 1 and 2; p independently represents an integer selected from 0, 1, 2 and 3; q independently represents an integer selected from 1, 2 and 3; or a pharmaceutically acceptable salt or solvate thereof, with the proviso that the compounds 8-hydroxy-3-methyl-7-phenylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 8-hydroxy-7-4-(hydroxyphenyl)sulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 7-phenylsulfonyl-1,2,3,4-tetrahydroisoquinoline and 7-phenylsulfonyl-1,2,3,4-tetrahydroisoquinoline hydrochloride are excluded. The compounds are useful in therapy, in particular as antipsychotic agents.

公开(公告)号：US20050014938A1

公开(公告)日：2005-01-20

申请号：US10495414

申请日：2002-11-14

申请人： Laramie Gaster ,  John Harling ,  Jag Heer ,  Thomas Heightman ,  Andrew Payne

发明人： Laramie Gaster ,  John Harling ,  Jag Heer ,  Thomas Heightman ,  Andrew Payne

IPC分类号： A61K31/4192 ,  A61K31/4196 ,  A61K31/433 ,  A61K31/538 ,  A61P1/00 ,  A61P1/04 ,  A61P1/16 ,  A61P3/12 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P19/00 ,  A61P19/02 ,  A61P19/10 ,  A61P25/00 ,  A61P25/28 ,  A61P27/02 ,  A61P43/00 ,  C07D249/06 ,  C07D265/36 ,  C07D285/14 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D417/02 ,  C07D413/02 ,  C07

CPC分类号： C07D285/14 ,  C07D249/06 ,  C07D265/36 ,  C07D471/04

摘要： Phenyl substituted triazoles of formula (I) wherein R1 is naphthyl or phenyl optionally substituted with one or more substituents selected from halo, —O—C1-6alkyl, —S—C1-6alkyl, C1-6alkyl, C1-6haloalkyl, —O—(CH2)n-Ph, —S—(CH2)n-Ph, cyano, phenyl, and CO2R, wherein R is hydrogen or C1-6alkyl, and n is 0, 1, 2 or 3; or R1 is phenyl or pyridyl fused with an aromatic or non-aromatic cyclic ring of 5-7 members wherein said cyclic ring optionally contains up to three heteroatoms, independently selected from N, O and S, and N may be further optionally substituted by C1-6 alkyl, and wherein the cyclic ring may be optionally substituted by ═O; R2 and R3 are independently selected from H, C1-6alkyl, C1-6alkoxy, phenyl, NH(CH2)n-Ph, NH—C1-6alkyl, halo, alkoxy, CN, NO2, CONHR and SO2NHR; two of X1, X2 and X3 are N and the other is NR4 wherein R4 is hydrogen, C1-6alkyl, C3-7cycloalkyl, —(CH2)p—CN, —(CH2)p—CO2H, —(CH2)p—CONHR5R6, —(CH2)pCOR5, —(CH2)q(CR7)2, —(CH2)pOR5, (CH2)qCH═CH—CN, —(CH2)q—CH═CH—CO2H, —(CH2)p—CH═CH—CONHR5R6, —(CH2)pNHCOR8 or —(CH2)pNR9R10; R5 and R6 are independently hydrogen or C1-6alkyl; R7 is C1-6alkyl; R8 is C1-7alkyl, or optionally substituted aryl, heteroaryl, arylC1-6alkyl or heteroaryl C1-6alkyl; R9 and R10 are independently selected from hydrogen, C1-6alkyl, aryl and arylC1-6alkyl; p is 0-4; and q is 1-4 and salts and solvates thereof, are disclosed, as are methods for their preparation, pharmaceutical compositions containing them and their use in medicine.

摘要翻译： 式（I）的苯基取代的三唑，其中R 1是萘基或任选被一个或多个选自卤素，-OC 1-6烷基，-S-C 1-6烷基，C 1-6烷基，C 1-6卤代烷基，-O- （CH 2）n-Ph，-S-（CH 2）n-Ph，氰基，苯基和CO 2 R，其中R是氢或C 1-6烷基，n是0,1,2或3; 或R 1是与5-7个成员的芳族或非芳族环的稠合的苯基或吡啶基，其中所述环任选地含有至多三个独立地选自N，O和S的杂原子，并且N可以进一步任选地被C1 -6烷基，并且其中所述环状环可以任选地被= O取代; R2和R3独立地选自H，C1-6烷基，C1-6烷氧基，苯基，NH（CH2）n-Ph，NH-C1-6烷基，卤素，烷氧基，CN，NO2，CONHR和SO2NHR; X1，X2和X3中的两个是N，另一个是NR4，其中R4是氢，C1-6烷基，C3-7环烷基， - （CH2）p-CN， - （CH2）p-CO2H， - （CH2）p-CONHR5R6 ， - （CH2）pCOR5， - （CH2）q（CR7）2， - （CH2）pOR5，（CH2）qCH = CH-CN， - （CH2）q-CH = CH-CO2H， - （CH2） CH = CH-CONHR5R6， - （CH2）pNHCOR8或 - （CH2）p

公开(公告)号：US20080281644A1

公开(公告)日：2008-11-13

申请号：US12118391

申请日：2008-05-09

申请人： Andrew Payne

发明人： Andrew Payne

IPC分类号： G06Q10/00

CPC分类号： G06Q10/02

摘要： A method is provided for assisting users select seats for an event using a user interface to select a seat. The user interface includes at least one of, a price range slider, a number of seat selector, a seat ranking selector, a table of available seats and a venue map.

摘要翻译： 提供了一种用于辅助用户使用用户界面选择座席来选择座席的方法。 用户界面包括价格范围滑块，座位选择器，座位排名选择器，可用席位表和场地图中的至少一个。

公开(公告)号：US20080000812A1

公开(公告)日：2008-01-03

申请号：US11818192

申请日：2007-06-13

申请人： Brian Reistad ,  William Snapper ,  Andrew Payne ,  James Campbell

发明人： Brian Reistad ,  William Snapper ,  Andrew Payne ,  James Campbell

IPC分类号： G06F15/16

CPC分类号： H04L51/32 ,  G06F3/04847 ,  G06Q10/06316 ,  G06Q30/02 ,  G06Q30/0201 ,  G06Q30/0235 ,  G06Q30/0239 ,  G06Q30/0241 ,  G06Q30/0255 ,  G06Q30/0271 ,  H04L51/04 ,  H04L51/22

摘要： Systems and methods for carrying on marketing dialogues are disclosed. Specifically, embodiments of the systems and methods presented may allow marketing dialogues to be carried on with a set of participants by sending a communication to each of the participants. Another set of participant may be assembled from the initial participants and an action may then be taken with respect to this second set of participants.

摘要翻译： 披露了进行营销对话的系统和方法。 具体地，所呈现的系统和方法的实施例可以允许通过向每个参与者发送通信来与一组参与者进行营销对话。 另一组参与者可以从初始参与者组装，然后可以针对第二组参与者采取行动。

公开(公告)号：US20070093473A1

公开(公告)日：2007-04-26

申请号：US10571220

申请日：2004-09-09

申请人： David Cooper ,  Ian Forbes ,  Vincenzo Garzya ,  Andrew Gribble ,  Andrew Lightfoot ,  Andrew Payne ,  Alexander Smith

发明人： David Cooper ,  Ian Forbes ,  Vincenzo Garzya ,  Andrew Gribble ,  Andrew Lightfoot ,  Andrew Payne ,  Alexander Smith

IPC分类号： A61K31/55 ,  C07D403/02 ,  C07D409/02

CPC分类号： C04B35/632 ,  C07D401/12 ,  C07D409/12

摘要： The invention provides compounds of formula (I): wherein A and B represent the groups —(CH2)m— and —(CH2)n— respectively; R1 represents hydrogen or C1-6alkyl; R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pOC3-6cycloalkyl, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR3R4, —SO2NR3R4, —(CH2)pNR3R4, —(CH2)pNR3COR4, optionally substituted aryl ring, optionally substituted heteroaryl ring, a fused bicyclic heteroaromatic ring system or optionally substituted heterocyclyl ring; Ar1 represents optionally substituted heteroaryl ring; Ar2 represents optionally substituted aryl ring or optionally substituted heteroaryl ring; Z represents —(CH2)qX— wherein the —(CH2)q— group is attached to Ar2, or —X(CH2)q— wherein X is attached to Ar2, and wherein any of the —CH2— groups may be optionally substituted by one or more C1-6alkyl groups; X represents oxygen, —CH(OR5)—, —NR5— or —CH2— wherein the —CH2— group may be optionally substituted by one or more C1-6alkyl groups; R3 and R4 each independently represent hydrogen, C1-6alkyl or, together with the nitrogen or other atoms to which they are attached, form an azacycloalkyl ring or an oxo-substituted azacycloalkyl ring; R5 represents hydrogen or C1-6alkyl; m and n independently represent an integer selected from 1 and 2; p independently represents an integer selected from 0, 1, 2 and 3; q independently represents an integer selected from 0, 1, 2 and 3; or a pharmaceutically acceptable salt or solvate thereof, with the proviso that when Ar1 is a pyridyl group, and Z is —CH2X— where X is attached to the Ar1 group, X is selected from —CH(OR5)—, —NR5— and —CH2— wherein the —CH2— group may be optionally substituted by one or more C1-6alkyl groups. The compounds of formula (I) are useful in therapy, in particular as antipsychotic agents.

公开(公告)号：US20070259344A1

公开(公告)日：2007-11-08

申请号：US11417313

申请日：2006-05-03

申请人： Eric M. Leproust ,  Douglas A. Amorese ,  Michael P. Caren ,  David B. Gordon ,  Andrew Payne

发明人： Eric M. Leproust ,  Douglas A. Amorese ,  Michael P. Caren ,  David B. Gordon ,  Andrew Payne

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12M3/00

CPC分类号： C12Q1/6837 ,  C12Q2565/507 ,  C12Q2525/197

摘要： Methods and articles for analyzing nucleotide sequences of nucleic acid molecules, e.g., using multiple probes per spot of an array, are described. In some embodiments, the methods and articles can reduce the numbers of arrays necessary to probe regions of interest in a biological sample, and/or increase the resolution at which biological events are probed. In some cases, these methods exploit the vertical aspect of an array in order to decrease the number of arrays or spots required for an assay. These probes may be in the form of compound probes, which comprise at least first and second probes, including first and second nucleotide sequences capable of hybridizing to first and second target nucleotide sequences, respectively, in a nucleic acid molecule of interest.

摘要翻译： 描述了分析核酸分子的核苷酸序列的方法和制品，例如每个阵列点使用多个探针。 在一些实施方案中，所述方法和制品可以减少探测生物样品中感兴趣区域所需的阵列数量和/或增加探测生物学事件的分辨率。 在某些情况下，这些方法利用阵列的垂直方面，以减少测定所需的阵列数或点数。 这些探针可以是化合物探针的形式，其包含至少第一和第二探针，包括分别在目的核酸分子中能够与第一和第二靶核苷酸序列杂交的第一和第二核苷酸序列。