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公开(公告)号：US20110143335A1
公开(公告)日：2011-06-16
申请号：US12908750
申请日：2010-10-20
IPC分类号： C12Q1/70 , G01N30/00 , G01N33/53 , C12M1/34 , G01N33/566
CPC分类号： G01N33/558
摘要： Methods and systems to capture competitive molecules, such as to reduce false positives in an assay. Competitive molecules may be captured in a fluid moving through a portable point-of-care diagnostic assay system.
摘要翻译： 捕获竞争性分子的方法和系统，例如在测定中减少假阳性。 竞争分子可以通过便携式点对点诊断测定系统捕获在流体中。
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公开(公告)号：US20110152720A1
公开(公告)日：2011-06-23
申请号：US12908822
申请日：2010-10-20
CPC分类号： G01N33/558 , B01L3/502 , B01L3/5025 , B01L3/502723 , B01L3/50273 , B01L3/5029 , B01L2200/0684 , B01L2200/10 , B01L2300/043 , B01L2300/045 , B01L2300/0636 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/0832 , B01L2300/0867 , B01L2400/0478 , G01N33/54366
摘要： Methods and systems to prepare a sample, including a relatively small amount of a biological sample, and to mix the sample with preparation fluid stored in a device. The device may include multiple fluid chambers and a stepped plunger to force a fluid in at least one of the chambers into a sample receiving chamber and then to a storage chamber. Methods and systems disclosed herein may be implemented to collect and controllable mix a sample for analysis and/or storage.
摘要翻译： 制备样品的方法和系统，包括相对少量的生物样品，并将样品与储存在装置中的制备液混合。 该装置可以包括多个流体室和阶梯式柱塞，以迫使至少一个室中的流体进入样品接收室，然后到达储存室。 可以实施本文公开的方法和系统以收集和控制混合用于分析和/或存储的样品。
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3.发明申请METHODS AND SYSTEMS TO CONTROL FLUID FLOW IN ACCORDANCE WITH A PREDETERMINED SEQUENCE 审中-公开根据预测序列控制流体流动的方法和系统公开(公告)号：US20110124129A1
公开(公告)日：2011-05-26
申请号：US12908815
申请日：2010-10-20
IPC分类号： G01N33/543
CPC分类号： G01N33/558
摘要： Methods and systems to perform sequential user-controlled fluidic assays, using substantially self-contained, portable, user-initiated fluidic assay systems, including user-initiated activation methods and systems.
摘要翻译： 使用基本上独立的便携式用户引发的流体测定系统（包括用户启动的激活方法和系统）来执行顺序用户控制的流体测定的方法和系统。
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4.发明申请METHODS AND SYSTEMS TO COLLECT AND PREPARE SAMPLES, TO IMPLEMENT, INITIATE AND PERFORM ASSAYS, AND TO CONTROL AND MANAGE FLUID FLOW 审中-公开收集和准备样品的方法和系统，实施，启动和执行测试以及控制和管理流体流公开(公告)号：US20110117673A1
公开(公告)日：2011-05-19
申请号：US12959140
申请日：2010-12-02
IPC分类号： G01N33/543
CPC分类号： G01N33/558
摘要： Methods and systems to related to sample collection, assays, and fluid control and management. Methods and systems disclosed herein, and portions thereof, may be implemented alone and/or in various combinations with one another.
摘要翻译： 与样品收集，测定和流体控制和管理相关的方法和系统。 本文公开的方法和系统及其部分可以单独实现和/或彼此以各种组合来实现。
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5.发明授权Methods of preparing and operating portable, point-of-care, user-initiated fluidic assay systems 有权制备和操作便携式，点对点，用户启动的流体测定系统的方法公开(公告)号：US08846310B2
公开(公告)日：2014-09-30
申请号：US13209878
申请日：2011-08-15
IPC分类号： C12M1/34 , G01N33/558
CPC分类号： G01N33/558
摘要： Methods of preparing assays and of assaying, using substantially self-contained, portable, user-initiated fluidic assay systems. Example assays include diagnostic assays and chemical detection assays. Diagnostic assays may include, without limitation, enzyme-linked immuno-sorbent assays (ELISA), and may include one or more sexually transmitted disease (STD) diagnostic assays. An assay system may include one or more fluid chambers, one or more fluid paths amongst the fluid chambers and/or between the fluid chambers, a sample portion, and/or an assay portion. The assay system may include a fluid controller system to dispense fluid from the one or more fluid chambers, and a user-initiated actuator to control the fluid controller system. The fluid controller system may be configured to dispense fluids serially, and may be configured to mix a plurality of fluids. The user-initiated actuator system may include an external user-operated trigger mechanism. The assay apparatus may include a display window to view assay results.
摘要翻译： 使用基本上独立的便携式用户引发的流体测定系统来制备测定和测定方法。 实例化验包括诊断测定和化学检测测定。 诊断测定可以包括但不限于酶联免疫吸附测定（ELISA），并且可以包括一种或多种性传播疾病（STD）诊断测定。 测定系统可以包括一个或多个流体室，流体室之间和/或流体室之间的一个或多个流体路径，样品部分和/或测定部分。 测定系统可以包括用于从一个或多个流体室分配流体的流体控制器系统以及用户启动的致动器来控制流体控制器系统。 流体控制器系统可以被配置为串联分配流体，并且可以被配置为混合多个流体。 用户启动的致动器系统可以包括外部用户操作的触发机构。 测定装置可以包括用于观察测定结果的显示窗口。
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6.发明申请METHODS AND SYSTEMS TO PREVENT GAS BUBBLES FROM INTERFERING WITH FLOW OF FLUID THROUGH A MEMBRANE REGION 审中-公开通过膜区域阻止流体流动阻止气体泡沫的方法和系统公开(公告)号：US20110151486A1
公开(公告)日：2011-06-23
申请号：US12908803
申请日：2010-10-20
申请人： Thomas M. Zappia , Brandon T. Johnson , David Butz
发明人： Thomas M. Zappia , Brandon T. Johnson , David Butz
CPC分类号： G01N33/558
摘要： Methods and systems to remove gas bubbles from liquids and to improve uniform fluid flow through a region of a membrane in a microfluidic device, including to reduce, remove, and/or prevent gas bubbles on a surface of a porous membrane. An example membrane bubble trap system may include a fluid channel connected to a bubble pathway that surrounds an opening sealed with a membrane. The bubble pathway may be configured to collect bubbles in fluid that passes through the membrane through buoyancy forces and through a directional feature of a curved surface placed above the membrane.
摘要翻译： 从液体中除去气泡并改善在微流体装置中通过膜的区域的均匀流体流动的方法和系统，包括减少，去除和/或防止多孔膜表面上的气泡。 示例性膜气泡捕集系统可以包括连接到气泡通道的流体通道，该气泡通道围绕用膜密封的开口。 气泡通道可以被配置成在液体中收集气泡，其通过浮力穿过膜并且通过位于膜上方的弯曲表面的方向特征。
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7.发明申请METHODS AND SYSTEMS TO COLLECT AND PREPARE SAMPLES, TO IMPLEMENT, INITIATE AND PERFORM ASSAYS, AND TO CONTROL AND MANAGE FLUID FLOW 审中-公开收集和准备样品的方法和系统，实施，启动和执行测试以及控制和管理流体流公开(公告)号：US20110151432A1
公开(公告)日：2011-06-23
申请号：US12908829
申请日：2010-10-20
CPC分类号： G01N33/558 , A61B10/0045 , B01L3/502 , B01L2300/0636 , B01L2400/0478 , G01N33/54366 , Y10T436/25375
摘要： Methods and systems to related to sample collection, assays, and fluid control and management, including methods and systems to implement hand-held portable assays, to activate an assay system, to collect and prepare samples, to capture antibodies, and to trap or capture gas bubbles. Methods and systems disclosed herein, and portions thereof, may be implemented alone and/or in various combinations with one another.
摘要翻译： 与样品收集，测定和流体控制和管理相关的方法和系统，包括实施手持式便携式测定的方法和系统，激活测定系统，收集和制备样品，捕获抗体，捕获或捕获 气泡。 本文公开的方法和系统及其部分可以单独实现和/或彼此以各种组合来实现。
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公开(公告)号：US20140050620A1
公开(公告)日：2014-02-20
申请号：US13945900
申请日：2013-07-19
IPC分类号： G01N33/50
CPC分类号： G01N33/50 , A61B5/145 , A61B5/15003 , A61B5/150221 , A61B5/150236 , A61B5/150251 , A61B5/150343 , A61B5/150748 , A61B5/150755 , A61B5/706 , B01L3/502 , B01L2300/0832 , B01L2300/0838 , B01L2400/0406 , B01L2400/0478 , G01N1/38
摘要： Sample processing methods and systems to collect a biological sample. A device may be configured collect a predetermined volume of a sample in sample chamber, and seal the chamber upon activation. The device may be further configured to mix the mix the sample with a predetermined volume of a reagent and/or mix the sample and the reagent in a pre-determined ration.
摘要翻译： 用于收集生物样品的样品处理方法和系统。 可以将装置配置成在样品室中收集预定体积的样品，并且在激活时密封腔室。 该装置还可以被配置成将样品与预定体积的试剂混合和/或以预定比例混合样品和试剂。
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9.发明申请METHODS OF PREPARING AND OPERATING PORTABLE, POINT-OF-CARE, USER-INITIATED FLUIDIC ASSAY SYSTEMS 有权便携式，点关心，用户启动的流体测定系统的制备和操作方法公开(公告)号：US20110300563A1
公开(公告)日：2011-12-08
申请号：US13209878
申请日：2011-08-15
申请人： Brandon T. Johnson , Tom Zappia , David A. Vogler
发明人： Brandon T. Johnson , Tom Zappia , David A. Vogler
IPC分类号： G01N33/566
CPC分类号： G01N33/558
摘要： Methods of preparing assays and of assaying, using substantially self-contained, portable, user-initiated fluidic assay systems. Example assays include diagnostic assays and chemical detection assays. Diagnostic assays may include, without limitation, enzyme-linked immuno-sorbent assays (ELISA), and may include one or more sexually transmitted disease (STD) diagnostic assays. An assay system may include one or more fluid chambers, one or more fluid paths amongst the fluid chambers and/or between the fluid chambers, a sample portion, and/or an assay portion. The assay system may include a fluid controller system to dispense fluid from the one or more fluid chambers, and a user-initiated actuator to control the fluid controller system. The fluid controller system may be configured to dispense fluids serially, and may be configured to mix a plurality of fluids. The user-initiated actuator system may include an external user-operated trigger mechanism. The assay apparatus may include a display window to view assay results.
摘要翻译： 使用基本上独立的便携式用户引发的流体测定系统来制备测定和测定方法。 实例化验包括诊断测定和化学检测测定。 诊断测定可以包括但不限于酶联免疫吸附测定（ELISA），并且可以包括一种或多种性传播疾病（STD）诊断测定。 测定系统可以包括一个或多个流体室，流体室之间和/或流体室之间的一个或多个流体路径，样品部分和/或测定部分。 测定系统可以包括用于从一个或多个流体室分配流体的流体控制器系统以及用户启动的致动器来控制流体控制器系统。 流体控制器系统可以被配置为串联分配流体，并且可以被配置为混合多个流体。 用户启动的致动器系统可以包括外部用户操作的触发机构。 测定装置可以包括用于观察测定结果的显示窗口。
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10.发明授权公开(公告)号：US08021873B2
公开(公告)日：2011-09-20
申请号：US12228081
申请日：2008-07-16
申请人： Brandon T. Johnson , Tom Zappia , David A. Vogler
发明人： Brandon T. Johnson , Tom Zappia , David A. Vogler
IPC分类号： C12M1/34
CPC分类号： G01N33/558
摘要： Methods and systems to perform point-of-care, user-initiated fluidic assays, using substantially self-contained, portable, user-initiated fluidic assay systems. Exemplary assays include diagnostic assays and chemical detection assays. Diagnostic assays may include, without limitation, enzyme-linked immuno-sorbent assays (ELISA), and may include one or more sexually transmitted disease (STD) diagnostic assays. An exemplary assay system includes a housing having one or more fluid chambers, a fluid controller system to dispense fluid from the one or more fluid chambers, and a user-initiated actuator to control the fluid controller system. The actuator may be configured to move fluid controllers from functionally closed positions to functionally open positions, to control fluid flow from the fluid chambers. The fluid controller system may be configured to dispense fluids serially, and may be configured to mix a plurality of fluids. The housing may include one or more fluid paths amongst the fluid chambers and/or between the fluid chambers and an assay portion, and the fluid controller system may be configured to serially align fluid chamber outlets with corresponding fluid paths. The user-initiated actuator system may include an external user-operated trigger mechanism to initiate the actuator system. The actuator system may include a mechanical actuator system, and may include a compressible spring actuator system. The assay apparatus may include a display window to view assay results. Exemplary methods of preparing portable, user-initiated fluidic assay systems, and methods of using portable, user-initiated fluidic assay systems are disclosed.
摘要翻译： 使用基于自给自足的便携式用户引发的流体测定系统进行用户启动的流体测定的方法和系统。 示例性测定包括诊断测定和化学检测测定。 诊断测定可以包括但不限于酶联免疫吸附测定（ELISA），并且可以包括一种或多种性传播疾病（STD）诊断测定。 示例性分析系统包括具有一个或多个流体室的壳体，用于从一个或多个流体室分配流体的流体控制器系统以及用户启动的致动器以控制流体控制器系统。 致动器可以被配置为将流体控制器从功能关闭位置移动到功能打开位置，以控制来自流体室的流体流动。 流体控制器系统可以被配置为串联分配流体，并且可以被配置为混合多个流体。 壳体可以包括在流体室之间和/或在流体室和测定部分之间的一个或多个流体路径，并且流体控制器系统可以被配置为使流体室出口与相应的流体路径串联对准。 用户启动的致动器系统可以包括用于启动致动器系统的外部用户操作的触发机构。 致动器系统可以包括机械致动器系统，并且可以包括可压缩的弹簧致动器系统。 测定装置可以包括用于观察测定结果的显示窗口。 公开了制备便携式，用户启动的流体测定系统的示例性方法以及使用便携式用户引发的流体测定系统的方法。
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