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公开(公告)号：US5624396A
公开(公告)日：1997-04-29
申请号：US550160
申请日：1995-10-30
CPC分类号： A61M29/02 , A61B17/22 , A61M25/09 , A61B2017/22084 , A61M2025/09083 , A61M2025/091 , A61M2025/109 , A61M2025/1093 , A61M25/0105
摘要： A system for use in delivering a thrombolytic agent to a firm obstruction in a blood vessel by effecting longitudinal extension of the distal infusion segment of an infusion device through the obstruction as the obstruction is dissolved by the delivery of the thrombolytic agent. The infusion device is inserted into the lumen of an introducer to straighten the distal infusion segment and the assembly is advanced through a selected path in a patient's vascular system to the obstructed site. The distal infusion segment is advanced from a distal end opening of the introducer sheath lumen and assumes the pre-biased J-shaped bend configuration when positioned that tends to present the infusion port in a side wall toward the obstruction. A spring loaded assembly is coupled between the proximal ends of the infusion device and the introducer catheter that applies a force axially along the body of the infusion device against the resistance of the obstruction in contact with the distal infusion segment. As the dissolving agent is delivered and the obstruction dissolves, the distal infusion segment tunnels through the soft obstruction under the influence of the applied axial force.
摘要翻译： 一种用于将血栓溶解剂输送到血管中的坚固阻塞物的系统，其通过阻塞物通过溶栓剂的输送溶解而通过阻塞物进行输注装置的远端输注段的纵向延伸。 将输注装置插入导引器的内腔以矫正远端输注部分，并且组件通过患者血管系统中的选定路径前进到阻塞部位。 远端输注部分从引导器套管内腔的远端开口前进，并且当定位时呈现预偏压的J形弯曲构造，其倾向于将侧壁中的输注端口呈向阻塞。 弹簧加载的组件联接在输注装置的近端和引导器导管之间，该引导器导管克服抗与远端输注段接触的阻力沿着输注装置的主体轴向地施加力。 当溶解剂被输送并且阻塞物溶解时，远端输注部分在施加的轴向力的影响下穿过软质阻塞物。
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公开(公告)号：US5147370A
公开(公告)日：1992-09-15
申请号：US713770
申请日：1991-06-12
申请人： Thomas O. McNamara , Gregory Mednik
发明人： Thomas O. McNamara , Gregory Mednik
CPC分类号： A61F2/95 , A61F2/88 , A61F2002/9505 , A61F2002/9511 , A61F2210/0019
摘要： Disclosed is a coil stent constructed from a nitinol alloy having the ends thereof shaped to interact with a placement device specifically designed to hold the stent in a reduced diameter while it is being maniuplated to its desired position in the patient's body. The placement device is a hollow tube which has holes in it surface allowing placement of the ends of the stent therethrough so that they can be held in place inside the interior of the placement device by a mandril which is threaded through the center of the placement device. The combination of the features of the shapes on the end of the stent, the holes in the placement device and the mandril which passes through the placement device and the shapes on the end of the stent allow the interventional radiologist to accurately and rapidly place the stent in its desired position before it changes shape to its final pre-set configuration.
摘要翻译： 公开了一种由镍钛诺合金构成的线圈支架，其具有其端部的形状，以使其与特别设计用于将支架保持在直径减小的放置装置相互作用，同时将其放置在患者身体中的期望位置。 放置装置是一种中空管，其中具有孔，其中允许支架的端部放置在其中，使得它们可以通过穿过安置装置的中心的心轴保持在放置装置内部的适当位置 。 支架端部的形状特征，放置装置中的孔和通过放置装置的心轴以及支架端部上的形状的组合可使介入放射科医师准确且快速地放置支架 在其形状改变到其最终预设置配置之前处于其期望的位置。
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公开(公告)号：US06254550B1
公开(公告)日：2001-07-03
申请号：US09377293
申请日：1999-08-19
IPC分类号： A61B500
CPC分类号： A61M25/09 , A61M2025/09175
摘要： A preformed anchoring wire guide (10) for medical procedures such as renal angioplasty. The wire guide (10) is comprised of a superelastic memory alloy mandril (11), such as a nickel-titanium alloy, and includes a preformed bend (14) having an angle (15) with respect to the longitudinal axis (28) that corresponds with the takeoff angle of the renal artery (23) relative to the aorta (33). This preformed bend (14) allows easier access to the ostium (22) of the renal artery (23) and allows the distal portion (27) of the wire guide to anchor within the artery (23) and resist dislodgement and deformation, thereby improving trackability of a balloon angioplasty catheter (21), reducing the need for a guiding catheter, and reducing the likelihood of vessel damage or thrombus shear due to forces that are normally exerted against the wall of the vessel (33) by a standard wire guide. The wire guide has a tapered distal portion (20) over which a spring coil wire (16) is attached to provide radiopacity and safety to the vasculature. The distal portion (27) of the wire guide is flexible and is further made atraumatic by the addition of a hook-shaped or “J” tip (29). Additionally, the nickel-titanium alloy mandril is cold-worked in its austenitic phase at preformed bend (14) by overstressing the wire in a fixture, thereby shifting at least part of the crystalline structure to martensite within the region of the preformed bend (14).
摘要翻译： 一种用于诸如肾血管成形术之类的医疗程序的预成型锚固线导向器（10）。 线引导件（10）包括超弹性记忆合金心轴（11），例如镍 - 钛合金，并且包括相对于纵向轴线（28）具有角度（15）的预成形弯曲部（14）， 对应于肾动脉（23）相对于主动脉的起飞角（33）。 这个预成型的弯曲部（14）允许更容易地进入肾动脉（23）的口（22）并且允许电线引导件的远端部分（27）锚固在动脉（23）内并抵抗移位和变形，从而改善 气球血管成形术导管（21）的追踪性，减少对导向导管的需要，并减少由于通常通过标准线导向器施加在容器（33）的壁上的力引起的血管损伤或血栓剪切的可能性。 线引导件具有锥形远端部分（20），弹簧线圈线（16）在该锥形远端部分上连接以向脉管系统提供不透射线性和安全性。 线引导件的远端部分（27）是柔性的，并且通过添加钩形或“J”形尖端（29）进而进一步制成无创伤。 另外，通过对夹具中的导线进行过应力，在预成形的弯曲部（14）的奥氏体相中对镍 - 钛合金棒进行冷加工，从而将至少部分晶体结构转移到预成形弯曲部分（14）的区域内的马氏体 ）。
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公开(公告)号：US07993308B2
公开(公告)日：2011-08-09
申请号：US11046052
申请日：2005-01-28
IPC分类号： A61M25/00
CPC分类号： B08B9/00 , A61B17/2202 , A61B90/70 , A61B2090/701 , A61M2025/0019 , B08B9/043 , B08B2209/005
摘要： A central venous catheter comprises an ultrasound assembly. In one arrangement, the radiating member is used to remove a blockage from the central venous catheter. In another arrangement, inserting an ultrasound assembly into a central venous catheter. The ultrasound assembly comprises an ultrasound radiating member mounted on an elongate support structure. The method further comprises positioning the ultrasound assembly within the central venous catheter such that the ultrasound radiating member is adjacent to a deposited material formed on a portion of the central venous catheter. The method further comprises supplying an electrical current to the ultrasound radiating member to expose the deposited material to ultrasonic energy. The method further comprises passing a therapeutic compound through the central venous catheter to expose the deposited material to the therapeutic compound simultaneously with ultrasonic energy.
摘要翻译： 中心静脉导管包括超声组件。 在一种布置中，辐射构件用于从中心静脉导管移除堵塞物。 在另一种布置中，将超声组件插入中心静脉导管中。 超声组件包括安装在细长支撑结构上的超声辐射构件。 该方法还包括将超声组件定位在中心静脉导管内，使得超声辐射构件与形成在中心静脉导管的一部分上的沉积材料相邻。 该方法还包括向超声辐射构件提供电流以将沉积的材料暴露于超声波能量。 该方法还包括使治疗化合物通过中心静脉导管，以同时用超声能量将沉积的材料暴露于治疗化合物。
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