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14 条记录 (耗时 0.036 秒)

    Reversible geling co-polymer and method of making
    6.
    发明授权
    Reversible geling co-polymer and method of making 失效
    可逆凝胶共聚物及其制备方法

    公开(公告)号：US06979464B2

    公开(公告)日：2005-12-27

    申请号：US09209541

    申请日：1998-12-11

    申请人： Anna Gutowska

    发明人： Anna Gutowska

    IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K47/32 ,  A61K9/14

    CPC分类号： A61K9/0019 ,  A61K9/2027 ,  A61K47/32

    摘要： The present invention is a thereapeutic agent carrier having a thermally reversible gel or geling copolymer that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum geling molecular weight cutoff and a therapeutic agent.

    摘要翻译： 本发明是具有热可逆凝胶或凝胶共聚物的治疗剂载体，其为[甲基]丙烯酰胺衍生物和亲水性共聚单体的线性无规共聚物，其中线性无规共聚物为多条线性链 具有大于或等于最小凝胶分子量截留值的多个分子量和治疗剂。

    Multiple stimulus reversible hydrogels
    7.
    发明授权
    Multiple stimulus reversible hydrogels 有权
    多次刺激可逆水凝胶

    公开(公告)号：US06660247B1

    公开(公告)日：2003-12-09

    申请号：US09603730

    申请日：2000-06-23

    申请人： Anna Gutowska ,  Karol J. Krzyminski

    发明人： Anna Gutowska ,  Karol J. Krzyminski

    IPC分类号： A61K4900

    CPC分类号： A61K9/08 ,  A61K9/0019 ,  A61K9/2027 ,  A61K47/32

    摘要： A polymeric solution capable of gelling upon exposure to a critical minimum value of a plurality of environmental stimuli is disclosed. The polymeric solution may be an aqueous solution utilized in vivo and capable of having the gelation reversed if at least one of the stimuli fall below, or outside the range of, the critical minimum value. The aqueous polymeric solution can be used either in industrial or pharmaceutical environments. In the medical environment, the aqueous polymeric solution is provided with either a chemical or radioisotopic therapeutic agent for delivery to a specific body part. The primary advantage of the process is that exposure to one environmental stimuli alone will not cause gelation, thereby enabling the therapeutic agent to be conducted through the body for relatively long distances without gelation occurring.

    摘要翻译： 公开了能够在暴露于多个环境刺激的临界最小值时胶凝的聚合物溶液。 聚合物溶液可以是在体内使用的水溶液，并且如果至少一种刺激低于或超出临界最小值的范围，则能够使凝胶化反转。 聚合物水溶液可以在工业或制药环境中使用。 在医疗环境中，聚合物水溶液具有用于递送到特定身体部位的化学或放射性同位素治疗剂。 该方法的主要优点是单独暴露于一种环境刺激物不会引起凝胶化，从而使治疗剂能够通过身体传导相对较长距离而没有凝胶化。

    Multiple stimulus reversible hydrogels
    8.
    发明授权
    Multiple stimulus reversible hydrogels 有权

    公开(公告)号：US07033571B2

    公开(公告)日：2006-04-25

    申请号：US10701053

    申请日：2003-11-03

    申请人： Anna Gutowska ,  Karol J. Krzyminski

    发明人： Anna Gutowska ,  Karol J. Krzyminski

    IPC分类号： A61K51/00 ,  A61M36/14

    CPC分类号： A61K9/08 ,  A61K9/0019 ,  A61K9/2027 ,  A61K47/32

    摘要： A polymeric solution capable of gelling upon exposure to a critical minimum value of a plurality of environmental stimuli is disclosed. The polymeric solution may be an aqueous solution utilized in vivo and capable of having the gelation reversed if at least one of the stimuli fall below, or outside the range of, the critical minimum value. The aqueous polymeric solution can be used either in industrial or pharmaceutical environments. In the medical environment, the aqueous polymeric solution is provided with either a chemical or radioisotopic therapeutic agent for delivery to a specific body part. The primary advantage of the process is that exposure to one environmental stimuli alone will not cause gelation, thereby enabling the therapeutic agent to be conducted through the body for relatively long distances without gelation occurring.

    Stimulus sensitive gel with radioisotope and methods of making
    9.
    发明授权
    Stimulus sensitive gel with radioisotope and methods of making 有权
    刺激敏感凝胶与放射性同位素和制作方法

    公开(公告)号：US06869588B2

    公开(公告)日：2005-03-22

    申请号：US09853507

    申请日：2001-05-09

    申请人： Richard E. Weller ,  Michael A. Lind ,  Darrell R. Fisher ,  Anna Gutowska ,  Allison A. Campbell

    发明人： Richard E. Weller ,  Michael A. Lind ,  Darrell R. Fisher ,  Anna Gutowska ,  Allison A. Campbell

    IPC分类号： A61K9/10 ,  A61K47/34 ,  A61K51/00 ,  A61K51/06 ,  A61K51/12 ,  A61P35/00 ,  A61M36/14

    CPC分类号： A61K51/06 ,  A61K51/1213

    摘要： The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The gel is enhanced by either combining it with a biodegradable backbone and/or a therapeutic agent in a gelling solution made by mixing the copolymer with an aqueous solvent.

    摘要翻译： 本发明是一种热可逆刺激敏感凝胶或胶凝共聚物放射性同位素载体，其是[甲基]丙烯酰胺衍生物和亲水性共聚单体的线性无规共聚物，其中线性无规共聚物是多个直链的形式 具有大于或等于最小胶凝分子量截留值的多个分子量。 可生物降解骨架和/或治疗剂的添加赋予更多的效用。 制备热可逆刺激敏感胶凝共聚物放射性核素载体的本发明的方法具有以下步骤：（a）将刺激敏感的可逆胶凝共聚物与水性溶剂混合，作为刺激敏感的可逆胶凝溶液; 和（b）将放射性同位素与作为所述放射性同位素载体的所述刺激敏感性可逆胶凝溶液混合。 通过将共聚物与水性溶剂混合制成的胶凝溶液中的可生物降解骨架和/或治疗剂进行组合来增强凝胶。

    Stimulus sensitive gel with radioisotope and methods of making
    10.
    发明授权
    Stimulus sensitive gel with radioisotope and methods of making 失效
    刺激敏感凝胶与放射性同位素和制作方法

    公开(公告)号：US06296831B1

    公开(公告)日：2001-10-02

    申请号：US09058712

    申请日：1998-04-10

    申请人： Richard E. Weller ,  Michael A. Lind ,  Darrell R. Fisher ,  Anna Gutowska ,  Allison A. Campbell

    发明人： Richard E. Weller ,  Michael A. Lind ,  Darrell R. Fisher ,  Anna Gutowska ,  Allison A. Campbell

    IPC分类号： A61K5100

    CPC分类号： A61K51/06 ,  A61K51/1213

    摘要： The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The gel is enhanced by either combining it with a biodegradable backbone and/or a therapeutic agent in a gelling solution made by mixing the copolymer with an aqueous solvent.

    摘要翻译： 本发明是一种热可逆刺激敏感凝胶或胶凝共聚物放射性同位素载体，其是[甲基]丙烯酰胺衍生物和亲水共聚单体的线性无规共聚物，其中线性无规共聚物为多条直链形式，其具有 多个分子量大于或等于最小胶凝分子量截止值。 可生物降解骨架和/或治疗剂的添加赋予更多的效用。 制备热可逆刺激敏感胶凝共聚物放射性核素载体的本发明的方法具有以下步骤：（a）将刺激敏感的可逆胶凝共聚物与水性溶剂混合，作为刺激敏感的可逆胶凝溶液; 和（b）将放射性同位素与作为所述放射性同位素载体的所述刺激敏感性可逆胶凝溶液混合。 通过将共聚物与水性溶剂混合制成的胶凝溶液中的可生物降解骨架和/或治疗剂进行组合来增强凝胶。