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    Cosmetic and pharmaceutical preparations comprising photostable UV filters
    1.
    发明授权
    Cosmetic and pharmaceutical preparations comprising photostable UV filters 失效
    包含光稳定型紫外线过滤器的化妆品和药物制剂

    公开(公告)号：US6090374A

    公开(公告)日：2000-07-18

    申请号：US172672

    申请日：1998-10-15

    申请人： Thorsten Habeck ,  Sylke Haremza ,  Volker Schehlmann ,  Horst Westenfelder ,  Thomas Wunsch

    发明人： Thorsten Habeck ,  Sylke Haremza ,  Volker Schehlmann ,  Horst Westenfelder ,  Thomas Wunsch

    IPC分类号： A61K8/00 ,  A61K8/40 ,  A61K31/00 ,  A61P17/00 ,  A61P17/16 ,  A61Q1/04 ,  A61Q17/04 ,  A61K7/42 ,  A61K7/00 ,  A61K7/44

    CPC分类号： A61Q17/04 ,  A61K8/40 ,  A61Q1/04 ,  A61K2800/52

    摘要： The use of substituted .alpha.-methylstyrene derivatives of the formula I, ##STR1## where the variables have the following meanings: R.sup.1 C.sub.4 -C.sub.10 -alkoxy, C.sub.1 -C.sub.12 -alkylamino, C.sub.1 -C.sub.12 -dialkylamino, substituents which confer solubility in water and which are selected from the group consisting of carboxylate, sulfonate or ammonium residues;R.sup.2 hydrogen, C.sub.2 -C.sub.10 -alkyl, C.sub.1 -C.sub.12 -alkoxy;R.sup.3 COOR.sup.5, COR.sup.5, CONR.sup.5 R.sup.6, CN;R.sup.4 COOR.sup.5, COR.sup.5, CONR.sup.5 R.sup.6, CN; where the substituents R.sup.3 and R.sup.4 are identical in each case;R.sup.5 andR.sup.6 independently of one another hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.2 -C.sub.10 -alkenyl, C.sub.3 -C.sub.10 -cycloalkyl, C.sub.3 -C.sub.10 -cycloalkenyl, aryl, hetaryl, unsubstituted or substituted;as photostable UV filters in cosmetic and pharmaceutical preparations to protect the human skin or human hair from the sun's rays, alone or together with UV-absorbing compounds known per se for cosmetic and pharmaceutical preparations.

    摘要翻译： 使用式I的取代的α-甲基苯乙烯衍生物，其中变量具有以下含义：R 1 C 4 -C 10 - 烷氧基，C 1 -C 12 - 烷基氨基，C 1 -C 12 - 二烷基氨基，赋予在水中溶解度并且被选择的取代基 由羧酸盐，磺酸盐或铵残基组成的组; R2氢，C2-C10-烷基，C1-C12-烷氧基; R3 COOR5，COR5，CONR5R6，CN; R4 COOR5，COR5，CONR5R6，CN; 其中取代基R 3和R 4在每种情况下相同; R 5和R 6彼此独立地为氢，C 1 -C 12 - 烷基，C 2 -C 10 - 烯基，C 3 -C 10 - 环烷基，C 3 -C 10 - 环烯基，芳基，杂芳基，未取代或取代的; 作为化妆品和药物制剂中的光稳定紫外线过滤器，用于保护人体皮肤或人体毛发免受太阳光线的照射，或者与本身已知的用于化妆品和药物制剂的紫外线吸收化合物一起使用。

    Photo-stable cosmetic and pharmaceutical formulations containing UV-filters
    3.
    发明授权
    Photo-stable cosmetic and pharmaceutical formulations containing UV-filters 失效
    光稳定的化妆品和药物配方含有紫外线过滤器

    公开(公告)号：US5945091A

    公开(公告)日：1999-08-31

    申请号：US972391

    申请日：1997-11-18

    申请人： Thorsten Habeck ,  Alexander Aumuller ,  Volker Schehlmann ,  Horst Westenfelder ,  Thomas Wunsch

    发明人： Thorsten Habeck ,  Alexander Aumuller ,  Volker Schehlmann ,  Horst Westenfelder ,  Thomas Wunsch

    IPC分类号： A61K8/30 ,  A61K8/00 ,  A61K8/41 ,  A61K8/42 ,  A61K8/46 ,  A61K8/49 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  A61Q19/00 ,  C07C229/56 ,  C07C229/60 ,  C07C255/30 ,  C07C255/58 ,  C07C309/46 ,  C07D275/02 ,  C07D275/03 ,  C07D319/06 ,  C07D333/38 ,  A61K7/42 ,  A61K7/00 ,  A61K31/255 ,  A61K31/275 ,  A61K31/66

    CPC分类号： C07D275/03 ,  A61K8/411 ,  A61K8/42 ,  A61K8/466 ,  A61K8/49 ,  A61K8/498 ,  A61K8/4986 ,  A61Q1/04 ,  A61Q17/04 ,  C07C229/56 ,  C07C229/60 ,  C07C255/30 ,  C07C255/58 ,  C07C309/46 ,  C07D319/06 ,  C07D333/38 ,  A61K2800/52

    摘要： A method of using compounds of formula I ##STR1## in which the C.dbd.C double bond is present in E and/or Z configuration and the variables have the following meanings:R.sup.1 denotes COOR.sup.5, COR.sup.5, CONR.sup.5 R.sup.6, CN, O.dbd.S(--R.sup.5).dbd.O, O.dbd.S(--OR.sup.5).dbd.O, R.sup.7 O--P(--OR.sup.8).dbd.O;R.sup.2 denotes COOR.sup.6, COR.sup.6, CONR.sup.5 R.sup.6, CN, O.dbd.S(--R.sup.6).dbd.O, O.dbd.S(--OR.sup.6).dbd.O, R.sup.7 O--P(--OR.sup.8).dbd.O;R.sup.3 denotes hydrogen, an optionally substituted aliphatic, cycloaliphatic, araliphatic or aromatic radical having in each case up to 18 carbon atoms;R.sup.4 denotes an optionally substituted aromatic or heteroaromatic radical containing from 5 to 12 ring atoms;R.sup.5 toR.sup.8 independently denote hydrogen, an open-chain or branched-chain aliphatic, araliphatic, cycloaliphatic or optionally substituted aromatic radical containing in each case up to 18 carbon atoms,where the variables R.sup.3 to R.sup.8 may also form, together with the carbon atoms to which they are attached, a 5-membered or 6-membered ring, which may be anellated if desired,as UV filters, particularly UV-A filters, in cosmetic and pharmaceutical formulations for the protection of the human skin or human hair from solar radiation, alone or together with compounds known per se in cosmetic and pharmaceutical formulations and capable of absorbing radiation in the UV range.

    摘要翻译： 在E和/或Z构型中使用存在C = C双键的式I化合物的方法，并且变量具有以下含义：R 1表示COOR 5，COR 5，CONR 5 R 6，CN，O = S（-R 5） = O，O = S（-OR 5）= O，R 7 O-P（-OR 8）= O; R2表示COOR6，COR6，CONR5R6，CN，O = S（-R6）= O，O = S（-OR6）= O，R7O-P（-OR8）= O; R 3表示氢，任选取代的脂族，脂环族，芳脂族或芳族基团，其在每种情况下最多为18个碳原子; R4表示任选取代的芳族或杂芳族基团，其含有5至12个环原子; R5至R8独立地表示氢，开链或支链脂族，芳脂族，脂环族或任选取代的芳族基团，其在每种情况下含有至多18个碳原子，其中变量R3至R8也可与碳原子一起形成 它们所连接的是5元或6元环，如果需要，可以作为UV过滤剂，特别是UV-A过滤器，在用于保护人类皮肤或人类头发免受太阳能的化妆品和药物制剂中的影响 单独或与化妆品和药物制剂中本身已知的化合物一起辐射并且能够吸收UV范围内的辐射。

    Use of substituted vinyl-tetrahydronaphthalenes and vinyl-benzotetrahydropyrans as light protection agents
    8.
    发明授权
    Use of substituted vinyl-tetrahydronaphthalenes and vinyl-benzotetrahydropyrans as light protection agents 失效
    使用取代的乙烯基 - 四氢萘和乙烯基 - 苯并四氢吡喃作为防光剂

    公开(公告)号：US06680390B2

    公开(公告)日：2004-01-20

    申请号：US10173277

    申请日：2002-06-18

    申请人： Frank Prechtl ,  Thorsten Habeck ,  Horst Westenfelder ,  Thomas Wilnsch

    发明人： Frank Prechtl ,  Thorsten Habeck ,  Horst Westenfelder ,  Thomas Wilnsch

    IPC分类号： C07D31174

    CPC分类号： A61K8/40 ,  A61K8/368 ,  A61K8/37 ,  A61K8/498 ,  A61K2800/52 ,  A61Q17/04

    摘要： The invention relates to the use of compounds of the formula I in which X is the divalent radical of oxygen, a carbonyl radical, optionally aliphatically substituted imino or the radical ═CR9R10, Y is a carbonyl group or the radical ═CR9R10, R1 and R2 are identical or different electron-withdrawing radicals, chosen from the group consisting of cyano, alkyl- or arylcarbonyl, alkyloxy- or aryloxycarbonyl, optionally substituted aminocarbonyl, alkyl- or arylsulfinyl, alkyl- or arylsulfonyl and optionally substituted aminosulfonyl, R3 is a hydrogen atom, a cyano, hydroxyl, carboxyl or aminocarbonyl group or a C5-C20-aryl radical or C1-C20-alkylradical optionally bonded via an oxygen bridge, an aminocarbonyl bridge or oxycarbonyl bridge, R4 is a hydrogen atom, a hydroxyl group, an amino group, or a C5-C20-aryl radical or C1-C20-alkyl radical optionally bonded via an oxygen bridge, and R5 to R10 independently of one another are hydrogen or C1-C20-alkyl radicals and where in addition R7 and R8 together with the chain carbon atom are a carbonyl group, as photostable UV filters in cosmetic and pharmaceutical preparations for protecting human skin and human hair from solar rays, alone or together with compounds which absorb in the UV region and are known per se for cosmetic and pharmaceutical preparations.

    摘要翻译： 本发明涉及式Iin的化合物，其中X是氧的二价基团，羰基，任选地是脂族取代的亚氨基或基团= CR 9 R 10，Y是羰基或基团= CR 9 R 10，R 1和R 2是相同或不同的吸电子基团，选自氰基，烷基 - 或芳基羰基，烷氧基 - 或芳氧基羰基，任选取代的氨基羰基，烷基 - 或芳基亚磺酰基，烷基 - 或芳基磺酰基和任选取代的氨基磺酰基，R 3是氢原子，氰基，羟基，羧基或氨基羰基或C 5 -C 20 - 芳基或任选经氧连接的C 1 -C 20 - 烷基 桥，氨基羰基桥或氧羰基桥，R 4是氢原子，羟基，氨基或任选通过氧桥键合的C 5 -C 20 - 芳基或C 1 -C 20 - 烷基， R 5至R 10彼此独立地是氢或C 1 -C 20烷基，并且其中 R 7和R 8与链碳原子一起是羰基，作为用于保护人类皮肤和人类头发免受太阳光线影响的化妆品和药物制剂中的光稳定性UV过滤剂，单独或与在 UV区域，并且本身已知化妆品和药物制剂。

    Use of cyclic enamines as light protection agents
    9.
    发明授权
    Use of cyclic enamines as light protection agents 失效
    使用环状烯胺作为防晒剂

    公开(公告)号：US06603014B1

    公开(公告)日：2003-08-05

    申请号：US10053323

    申请日：2002-01-23

    申请人： Thorsten Habeck ,  Frank Prechtl ,  Thomas Wünsch ,  Horst Westenfelder

    发明人： Thorsten Habeck ,  Frank Prechtl ,  Thomas Wünsch ,  Horst Westenfelder

    IPC分类号： C07D27764

    CPC分类号： A61K8/4946 ,  A61K8/49 ,  A61K8/494 ,  A61K2800/52 ,  A61Q1/04 ,  A61Q17/04

    摘要： The use of compounds of the formula I in which R1 and R2 are identical or different, electron-withdrawing radicals chosen from the group consisting of cyano, alkyl- or arylcarbonyl, alkyloxy- or aryloxycarbonyl and optionally substituted aminocarbonyl, R3 is a hydrogen atom, a C1-C20-alkyl radical or a C3-C20-cycloalkyl radical or a radical of the formula —CH2—CH2—SO3—M+, where M+ is a cation, X is the divalent radical of oxygen, sulfur or the radical where R3 is as defined above, is the divalent radical of the formula II or III, which forms a fused system with the radical of the formula I where R4 can be bonded one or more times to the benzylidene ring I or naphthylidene ring II, and is hydrogen, alkyl, cycloalkyl, alkyloxy, cycloalkyloxy, alkoxycarbonyl, mono- or dialkylaminocarbonyl, alkylamino, dialkylamino, each having up to 20 carbon atoms, and also cyano, amino and SO3—M+, where M+ is a cation, as photostable UV filters in cosmetic and pharmaceutical preparations to protect human skin and human hair against solar rays, alone or together with compounds which absorb in the UV region and are known per se for cosmetic and pharmaceutical preparations.

    摘要翻译： 使用其中R 1和R 2相同或不同的式Iin化合物，选自氰基，烷基 - 或芳基羰基，烷氧基 - 或芳氧基羰基和任选取代的氨基羰基的吸电子基，R 3是氢原子，C 1 -C 20 - 烷基或C 3 -C 20环烷基或式-CH 2 -CH 2 -SO 3 -M +的基团，其中M +是阳离子，X是氧，硫或基团的二价基团，其中R3如所定义 是式II或III的二价基团，其与式I的基团形成稠合体系，其中R 4可以与亚苄基环I或亚萘基环II键合一次或多次，并且是氢，烷基，环烷基 ，烷氧基，环烷氧基，烷氧基羰基，单或二烷基氨基羰基，烷基氨基，二烷基氨基，各自具有至多20个碳原子，以及氰基，氨基和SO3-M +，其中M +是阳离子，作为化妆品和药物制剂中的光稳定性UV过滤剂 保护人体皮肤a 将人类头发抵抗太阳光线，单独或与在UV区域吸收的化合物一起，并且本身已知用于化妆品和药物制剂。